(Z)-1-<4-(2-bromoethoxy)phenyl>-2-chloro-1,2-diphenylethylene | 95764-36-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (Z)-1-<4-(2-bromoethoxy)phenyl>-2-chloro-1,2-diphenylethylene
• 英文别名: 1-(2-bromoethoxy)-4-[(Z)-2-chloro-1,2-diphenylethenyl]benzene
• CAS: 95764-36-6
• 化学式: C₂₂H₁₈BrClO
• 分子量: 413.741
• InChiKey: JJWIZGGLPOBKQJ-DQRAZIAOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4-羟基-二苯甲酮 在 盐酸 、 sodium methylate 、 氯 作用下， 以 四氯化碳 、 乙醚 、 乙醇 、 苯 为溶剂， 反应 28.5h， 生成 (Z)-1-<4-(2-bromoethoxy)phenyl>-2-chloro-1,2-diphenylethylene
  参考文献：
  名称：

  Isoxazoles with antipicornavirus activity

  摘要：

  The synthesis and evaluation of a series of 3,5-disubstituted isoxazoles as antipicornavirus agents have led to the discovery of several compounds effective in vitro against rhinovirus type 2 and poliovirus type 2. Compound 32 was found more effective than 4',6-dichloroflavan against both viruses and was evaluated orally in mice infected intracerebrally with polio-2. At 31 mg/kg bid, compound 32 showed a 53% survival rate as compared to 22% for the nonmedicated animals.

  DOI：

  10.1021/jm00383a010

文献信息

• Isoxazoles with antipicornavirus activity
  作者：Guy D. Diana、M. A. McKinlay、C. J. Brisson、E. S. Zalay、J. V. Miralles、U. J. Salvador

  DOI：10.1021/jm00383a010

  日期：1985.6

  The synthesis and evaluation of a series of 3,5-disubstituted isoxazoles as antipicornavirus agents have led to the discovery of several compounds effective in vitro against rhinovirus type 2 and poliovirus type 2. Compound 32 was found more effective than 4',6-dichloroflavan against both viruses and was evaluated orally in mice infected intracerebrally with polio-2. At 31 mg/kg bid, compound 32 showed a 53% survival rate as compared to 22% for the nonmedicated animals.