N-(2-hydroxyphenyl)-3,3-dimethylbutanamide | 1031940-93-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-hydroxyphenyl)-3,3-dimethylbutanamide
• CAS: 1031940-93-8
• 化学式: C₁₂H₁₇NO₂
• 分子量: 207.272
• InChiKey: BECOEELWDXAZBL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(2-hydroxyphenyl)-3,3-dimethylbutanamide 以 neat (no solvent) 为溶剂， 反应 2.0h， 生成 2-(2,2-Dimethylpropyl)benzoxazol
  参考文献：
  名称：

  A microwave assisted synthesis of benzoxazoles from carboxylic acids

  摘要：

  A series of various poly-substituted benzoxazoles were synthesized starting from readily available carboxylic acids. The method is based on TCT (cyanuric chloride)/microwave acid activation and it is characterized by mild conditions, allowing for a wide range of starting materials and functionalization of final products. (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.10.084
• 作为产物：
  描述：

  3,3-二甲基-1-丁酸 、 2-氨基苯酚 在 三聚氯氰 作用下， 以 二氯甲烷 为溶剂， 反应 0.67h， 生成 N-(2-hydroxyphenyl)-3,3-dimethylbutanamide
  参考文献：
  名称：

  A microwave assisted synthesis of benzoxazoles from carboxylic acids

  摘要：

  A series of various poly-substituted benzoxazoles were synthesized starting from readily available carboxylic acids. The method is based on TCT (cyanuric chloride)/microwave acid activation and it is characterized by mild conditions, allowing for a wide range of starting materials and functionalization of final products. (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.10.084

文献信息

• A microwave assisted synthesis of benzoxazoles from carboxylic acids
  作者：Giammario Nieddu、Giampaolo Giacomelli

  DOI：10.1016/j.tet.2012.10.084

  日期：2013.1

  A series of various poly-substituted benzoxazoles were synthesized starting from readily available carboxylic acids. The method is based on TCT (cyanuric chloride)/microwave acid activation and it is characterized by mild conditions, allowing for a wide range of starting materials and functionalization of final products. (c) 2012 Elsevier Ltd. All rights reserved.