1-(4-(Bromomethyl)phenyl)ethanol | 727992-46-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(4-(Bromomethyl)phenyl)ethanol
• 英文别名: 1-[4-(bromomethyl)phenyl]ethanol
• CAS: 727992-46-3
• 化学式: C₉H₁₁BrO
• 分子量: 215.09
• InChiKey: JCMSXOKRZLVZSB-UHFFFAOYSA-N

物化性质

• 沸点：
  291.6±20.0 °C(Predicted)
• 密度：
  1.433±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-(4-(Bromomethyl)phenyl)ethanol 在 sodium azide 作用下， 以 乙腈 为溶剂， 以94.5%的产率得到1-(4-(叠氮甲基)苯基)乙醇
  参考文献：
  名称：

  A chemoselective aerobic oxidation of benzylic azides catalyzed by molybdenum xanthate in an aqueous medium

  摘要：

  A mild molybdenum-catalyzed, aerobic, chemoselective oxidation of benzylic azides to the corresponding aldehydes in an aqueous medium that tolerates a variety of functional groups including alcohols, esters, ketones, halides and olefins is described. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.05.047

文献信息

• P(NMe₂)₃-Mediated Umpolung Alkylation and Nonylidic Olefination of α-Keto Esters
  作者：Sunewang Rixin Wang、Alexander T. Radosevich

  DOI：10.1021/acs.orglett.5b01784

  日期：2015.8.7

  A commercial phosphorus-based reagent (P(NMe2)(3)) mediates,umpolung alkylation of methyl aroylformates with benzylic and allylic bromides, leading to either Barer-type addition or ylide-free olefination products upon workup. The reaction sequence is initiated, by a two-electron redox addition of the tricoordinate phosphorus reagent with an alpha-keto ester Compound (Kukhtin-Ramirez addition). A mechanistic rationale is offered for the chemoselectivity upon which the success of this nonmetal mediated C-C bond forming strategy is based.
• A chemoselective aerobic oxidation of benzylic azides catalyzed by molybdenum xanthate in an aqueous medium
  作者：Mahagundappa Maddani、Kandikere Ramaiah Prabhu

  DOI：10.1016/j.tetlet.2008.05.047

  日期：2008.7

  A mild molybdenum-catalyzed, aerobic, chemoselective oxidation of benzylic azides to the corresponding aldehydes in an aqueous medium that tolerates a variety of functional groups including alcohols, esters, ketones, halides and olefins is described. (c) 2008 Elsevier Ltd. All rights reserved.