2-叔丁基环己胺 | 35735-41-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 2-叔丁基环己胺
• 英文名称: 2-tert-butylcyclohexylamine
• 英文别名: o-tert-butylcyclohexylamine；t-Butylcyclohexyl-2-amin；2-Tert-butylcyclohexanamine；2-tert-butylcyclohexan-1-amine
• CAS: 35735-41-2
• 化学式: C₁₀H₂₁N
• mdl: MFCD08558493
• 分子量: 155.283
• InChiKey: GEYTUFUSXAMSQK-UHFFFAOYSA-N

物化性质

• 沸点：
  86-88 °C(Press: 21 Torr)
• 密度：
  0.861±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2921300090

反应信息

• 作为反应物：
  描述：

  2-叔丁基环己胺 、 S-(1,3-苯并噻唑-2-基)硫代羟胺 生成 N-(1,3-benzothiazol-2-ylsulfanyl)-2-tert-butylcyclohexan-1-amine
  参考文献：
  名称：

  摘要：

  DOI：
• 作为产物：
  描述：

  2-叔-丁基环己酮 在 氨 、 氢气 、 盐酸 作用下， 以 乙醇 、 水 为溶剂， 100.0 ℃ 、4.0 MPa 条件下， 以92.2%的产率得到2-叔丁基环己胺
  参考文献：
  名称：

  一种潜手性酮的胺化及生物拆分

  摘要：

  本发明公开了一种以邻叔丁基环己酮为原料进行还原胺化及拆分的方法，本发明的具体方法是；先在催化剂的作用下邻叔丁基环己酮还原胺化生成外消旋邻叔丁基环己胺，邻叔丁基环己胺再经脂肪酶与消旋催化剂结合进行动态动力学拆分得R‑邻叔丁基环己胺。本发明具备操作简单、原料来源广、产品收率好、拆分产品光学纯度高等特点。

  公开号：

  CN106431933A

文献信息

• SULTAM DERIVATIVES
  申请人：Anderson Kevin W.

  公开号：US20110124686A1

  公开（公告）日：2011-05-26

  The present invention relates to compounds according to formula 1, which exhibit cytotoxic activity. The compounds may be used in the treatment of cancer.

  本发明涉及符合式1的化合物，具有细胞毒活性。这些化合物可用于治疗癌症。
• SUBSTITUTED THIAZOLIDINEDIONE INDAZOLES, INDOLES AND BENZOTRIAZOLES AS ESTROGEN-RELATED RECEPTOR-a MODULATORS
  申请人：Bignan Gilles

  公开号：US20110294780A1

  公开（公告）日：2011-12-01

  The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spondylitis, artherosclerosis, arthritis (such as rheumatoid arthritis, infectious arthritis, childhood arthritis, psoriatic arthritis, reactive arthritis), bone-related diseases (including those related to bone formation), breast cancer (including those unresponsive to anti-estrogen therapy), cardiovascular disorders, cartilage-related disease (such as cartilage injury/loss, cartilage degeneration, and those related to cartilage formation), chondrodysplasia, chondrosarcoma, chronic back injury, chronic bronchitis, chronic inflammatory airway disease, chronic obstructive pulmonary disease, diabetes, disorders of energy homeostasis, gout, pseudogout, lipid disorders, metabolic syndrome, multiple myeloma, obesity, osteoarthritis, osteogenesis imperfecta, osteolytic bone metastasis, osteomalacia, osteoporosis, Paget's disease, periodontal disease, polymyalgia rheumatica, Reiter's syndrome, repetitive stress injury, hyperglycemia, elevated blood glucose level, and insulin resistance.

  本发明涉及式(I)的化合物，制备这些化合物的方法，组合物，中间体及其衍生物，并用于治疗包括但不限于强直性脊柱炎，动脉粥样硬化，关节炎（如类风湿关节炎，感染性关节炎，儿童关节炎，银屑病性关节炎，反应性关节炎），与骨相关的疾病（包括与骨形成有关的疾病），乳腺癌（包括对抗雌激素治疗无效的癌症），心血管疾病，软骨相关疾病（如软骨损伤/丧失，软骨退化以及与软骨形成有关的疾病），软骨发育不良，软骨肉瘤，慢性腰部损伤，慢性支气管炎，慢性炎症性气道疾病，慢性阻塞性肺疾病，糖尿病，能量稳态紊乱，痛风，假性痛风，脂质紊乱，代谢综合征，多发性骨髓瘤，肥胖，骨关节炎，遗传性骨发育不全，骨溶解性骨转移，软骨软化症，骨质疏松症，帕金森病，牙周病，多肌痛风，Reiter综合征，重复性应激损伤，高血糖，血糖水平升高和胰岛素抵抗等病症的方法。
• [EN] PHOSPHINYL AMIDINE COMPOUNDS, METAL COMPLEXES, CATALYST SYSTEMS, AND THEIR USE TO OLIGOMERIZE OR POLYMERIZE OLEFINS<br/>[FR] COMPOSÉS DE PHOSPHINYLAMIDINE, COMPLEXES DE MÉTAL, SYSTÈMES DE CATALYSEUR, ET LEUR UTILISATION POUR OLIGOMÉRISER OU POLYMÉRISER DES OLÉFINES
  申请人：CHEVRON PHILLIPS CHEMICAL CO

  公开号：WO2011082192A1

  公开（公告）日：2011-07-07

  N2-phosphinyl amidine compounds, N2-phosphinyl amidinates, N2-phosphinyl amidine metal salt complexes, N2-phosphinyl amidinate metal salt complexes are described. Methods for making N2-phosphinyl amidine compounds, N2-phosphinyl amidinates, N2-phosphinyl amidine metal salt complexes, and N2-phosphinyl amidinate metal salt complexes are also disclosed. Catalyst systems utilizing the N2-phosphinyl amidine metal salt complexes and N2-phosphinyl amidinate metal salt complexes are also disclosed along with the use of the N2-phosphinyl amidine compounds, N2-phosphinyl amidinates, N2-phosphinyl amidine metal salt complexes, and N2-phosphinyl amidinate metal salt complexes for the oligomerization and/or polymerization of olefins.

  描述了N2-膦胺化合物、N2-膦胺酸盐、N2-膦胺金属盐络合物、N2-膦胺酸盐金属盐络合物。还公开了制备N2-膦胺化合物、N2-膦胺酸盐、N2-膦胺金属盐络合物和N2-膦胺酸盐金属盐络合物的方法。还公开了利用N2-膦胺金属盐络合物和N2-膦胺酸盐金属盐络合物的催化剂系统，以及利用N2-膦胺化合物、N2-膦胺酸盐、N2-膦胺金属盐络合物和N2-膦胺酸盐金属盐络合物进行烯烃的寡聚和/或聚合的用途。
• [EN] PHOSPHINYL FORMAMIDINE COMPOUNDS, METAL COMPLEXES, CATALYST SYSTEMS, AND THEIR USE TO OLIGOMERIZE OR POLYMERIZE OLEFINS<br/>[FR] COMPOSÉS PHOSPHINYL FORMAMIDINE, COMPLEXES MÉTALLIQUES, SYSTÈMES DE CATALYSEUR, ET LEUR UTILISATION POUR OLIGOMÉRISER OU POLYMÉRISER DES OLÉFINES
  申请人：CHEVRON PHILLIPS CHEMICAL CO

  公开号：WO2015094207A1

  公开（公告）日：2015-06-25

  N2-phosphinyl formamidine compounds and N2-phosphinyl formamidine metal salt complexes are described. Methods for making N2-phosphinyl formamidine compounds and N2-phosphinyl formamidine metal salt complexes are also disclosed. Catalyst systems utilizing the N2-phosphinyl formamidine metal salt complexes are also disclosed along with the use of the N2-phosphinyl amidine compounds and N2- phosphinyl amidinate metal salt complexes for the oligomerization and/or polymerization of olefins.

  描述了N2-磷酰基甲酰胺化合物和N2-磷酰基甲酰胺金属盐配合物。还公开了制备N2-磷酰基甲酰胺化合物和N2-磷酰基甲酰胺金属盐配合物的方法。还公开了利用N2-磷酰基甲酰胺金属盐配合物的催化剂体系，以及利用N2-磷酰基胺化合物和N2-磷酰基胺金属盐配合物进行烯烃的寡聚和/或聚合的用途。
• NOVEL DERIVATIVES OF 1-ALKYL-6-OXO-PIPERIDINE-3-CARBOXYLIC ACIDS AND 1-ALKYL-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACIDS AND THEIR USES AS COOLING COMPOUNDS
  申请人：Kazimierski Arkadiusz

  公开号：US20120129827A1

  公开（公告）日：2012-05-24

  The present invention relates to novel derivatives of 1-alkyl-6-oxo-piperidine-3-carboxylic acids and 1-alkyl-5-oxo-pyrrolidine-3-carboxylic acids represented by Formula I: wherein n is an integer of 1 or 2; R 1 , R 2 , R 3 , and R 4 are each independently selected from the group consisting of hydrogen and methyl; X is selected from the group consisting of oxygen and nitrogen; and R 5 is hydrogen or a C 1 -C 7 linear or branched acyclic hydrocarbon group, or R 5 together with X form a 3- to 8-membered heterocyclic hydrocarbon group, and their uses as cooling compounds.

  本发明涉及由式I所表示的新型1-烷基-6-氧代哌啶-3-羧酸和1-烷基-5-氧代吡咯烷-3-羧酸衍生物，其中n是1或2的整数；R1、R2、R3和R4分别独立地选自氢和甲基组成的基团；X选自氧和氮组成的基团；R5是氢或C1-C7线性或支链脂肪烃基团，或者R5与X一起形成3-至8-成员杂环脂肪烃基团，并且它们的用途是作为冷却剂。

表征谱图