N-acetyl-sulfanilic acid-(6-oxo-1,6-dihydro-pyrimidin-2-ylamide) | 70800-62-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-acetyl-sulfanilic acid-(6-oxo-1,6-dihydro-pyrimidin-2-ylamide)
• 英文别名: N-Acetyl-sulfanilsaeure-(6-oxo-1,6-dihydro-pyrimidin-2-ylamid)；N-[4-[(6-oxo-1H-pyrimidin-2-yl)sulfamoyl]phenyl]acetamide
• CAS: 70800-62-3
• 化学式: C₁₂H₁₂N₄O₄S
• 分子量: 308.318
• InChiKey: LNRZJYGHQQDXJZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  125
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-acetyl-sulfanilic acid-(6-oxo-1,6-dihydro-pyrimidin-2-ylamide) 在 sodium hydroxide 、 水 作用下， 生成 4-氨基-N-(6-氧代-1H-嘧啶-2-基)苯磺酰胺
  参考文献：
  名称：

  Matsukawa; Yoshida, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1949, vol. 69, p. 27,29

  摘要：

  DOI：
• 作为产物：
  描述：

  3-氧代丙酸 、 N-[4-[[(氨基亚胺甲基)氨基]磺酰基]苯基]-乙酰胺 生成 N-acetyl-sulfanilic acid-(6-oxo-1,6-dihydro-pyrimidin-2-ylamide)
  参考文献：
  名称：

  CH233766

  摘要：

  公开号：

文献信息

• Aging and Bilateral Symmetry Detection
  作者：A. M. Herbert、O. Overbury、J. Singh、J. Faubert

  DOI：10.1093/geronb/57.3.p241

  日期：2002.5.1

  The salience of bilateral symmetry varies as a function of the orientation of the symmetry axis. Vertical symmetry is most salient, followed by horizontal and then oblique orientations. We tested symmetry detection in different age groups to determine whether performance of this intermediate-level visual task is affected by normal, nonpathological aging. We tested forty participants and analyzed the results with respect to age group and symmetry orientation (vertical, horizontal, and 45 degree oblique). There was a vertical symmetry detection advantage for all participants, where sensitivity was highest for vertical symmetry, followed by horizontal symmetry, and then the oblique symmetry. Sensitivity to symmetry did not differ for the two younger age groups (aged 19-39 and 40-60), but declined significantly for the group aged 61-70, and declined again for the oldest group aged 71-80. This age-related difference in sensitivity to symmetry was not reflected in a measure of bias, where there were no differences as a function of age.
• Leitch et al., Canadian Journal of Research, Section B: Chemical Sciences, 1947, vol. 25, p. 14,17
  作者：Leitch et al.

  DOI：——

  日期：——
• Ohta; Kawasaki, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1951, vol. 71, p. 1309,1312
  作者：Ohta、Kawasaki

  DOI：——

  日期：——
• Production of sulfonamides
  申请人：WARD BIENKINSOP &

  公开号：US02471772A1

  公开（公告）日：1949-05-31
• CH233766
  申请人：——

  公开号：——

  公开（公告）日：——