ethyl 2-((4-methyl-N-(prop-2-ynyl)phenylsulfonamido)methyl)cycloprop-2-enecarboxylate | 1250283-30-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl 2-((4-methyl-N-(prop-2-ynyl)phenylsulfonamido)methyl)cycloprop-2-enecarboxylate
• 英文别名: Ethyl 2-[[(4-methylphenyl)sulfonyl-prop-2-ynylamino]methyl]cycloprop-2-ene-1-carboxylate
• CAS: 1250283-30-7
• 化学式: C₁₇H₁₉NO₄S
• 分子量: 333.408
• InChiKey: UGFJMUZAYOFFNN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  23
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  72.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  ethyl 2-((4-methyl-N-(prop-2-ynyl)phenylsulfonamido)methyl)cycloprop-2-enecarboxylate 、 烯丙基三甲氧基硅烷 在 Grubbs catalyst first generation 作用下， 反应 24.0h， 以60%的产率得到ethyl 2-(1-tosyl-4-vinyl-2,5-dihydro-1H-pyrrol-3-yl)-5-(trimethoxysilyl)pent-3-enoate
  参考文献：
  名称：

  Ruthenium-Catalyzed Tandem Ring-Opening/Ring-Closing/Cross-Metathesis of 1,6-Cyclopropene-ynes and Olefins for the Construction of the 3-Pyrroline Skeleton

  摘要：

  Catalyzed by the first-generation Grubbs' ruthenium complex, tandem intramolecular/intermolecular metathesis of 1,6-enynes bearing a cyclopropene ring took place smoothly to produce 3-pyrroline derivatives in satisfactory yields via ring-opening/ring-closing/cross-metathesis processes.

  DOI：

  10.1021/ol101455c
• 作为产物：
  描述：

  重氮乙酸乙酯 、 N,N-二炔丙基-对甲苯磺酰胺 在 dirhodium tetraacetate 作用下， 以 二氯甲烷 为溶剂， 以29%的产率得到ethyl 2-((4-methyl-N-(prop-2-ynyl)phenylsulfonamido)methyl)cycloprop-2-enecarboxylate
  参考文献：
  名称：

  Ruthenium-Catalyzed Tandem Ring-Opening/Ring-Closing/Cross-Metathesis of 1,6-Cyclopropene-ynes and Olefins for the Construction of the 3-Pyrroline Skeleton

  摘要：

  Catalyzed by the first-generation Grubbs' ruthenium complex, tandem intramolecular/intermolecular metathesis of 1,6-enynes bearing a cyclopropene ring took place smoothly to produce 3-pyrroline derivatives in satisfactory yields via ring-opening/ring-closing/cross-metathesis processes.

  DOI：

  10.1021/ol101455c

文献信息

• Ruthenium-Catalyzed Tandem Ring-Opening/Ring-Closing/Cross-Metathesis of 1,6-Cyclopropene-ynes and Olefins for the Construction of the 3-Pyrroline Skeleton
  作者：Zhi-Bin Zhu、Min Shi

  DOI：10.1021/ol101455c

  日期：2010.10.15

  Catalyzed by the first-generation Grubbs' ruthenium complex, tandem intramolecular/intermolecular metathesis of 1,6-enynes bearing a cyclopropene ring took place smoothly to produce 3-pyrroline derivatives in satisfactory yields via ring-opening/ring-closing/cross-metathesis processes.