(20S)-des-A,B-20-[4-(tert-butyldimethylsilyl)oxybutyl]pregnan-8-one | 913977-79-4

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: (20S)-des-A,B-20-[4-(tert-butyldimethylsilyl)oxybutyl]pregnan-8-one
• 英文别名: (20S)-de-A,B-20-[4-(tert-butyldimethylsilyloxy)butyl]pregnan-8-one；(1R,3aR,7aR)-1-[(2S)-6-[tert-butyl(dimethyl)silyl]oxyhexan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-one
• CAS: 913977-79-4
• 化学式: C₂₂H₄₂O₂Si
• 分子量: 366.66
• InChiKey: HFIXTFGXJPLNRB-LMVRJCEZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  25
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (20S)-des-A,B-20-[4-(tert-butyldimethylsilyl)oxybutyl]pregnan-8-one 在 氢氟酸 、 水 、 苯基锂 作用下， 以 四氢呋喃 、 乙醚 、 环己烷 、 乙腈 为溶剂， 反应 24.5h， 生成 (20S)-2-methylene-19,26,27-trinor-1α,25-dihydroxycalciferol
  参考文献：
  名称：

  WO2006/119309

  摘要：

  公开号：
• 作为产物：
  描述：

  (20R)-de-A,B-8β-[(tert-butyldimethylsilyl)oxy]-20-(iodomethyl)pregnane 在 吡啶 、 lithium aluminium tetrahydride 、 pyridinium dichromate 、 nickel(II) chloride hexahydrate 、 氢氟酸 、 4-甲基苯磺酸吡啶 、 三乙胺 、 锌 作用下， 以 四氢呋喃 、 二氯甲烷 、 乙腈 为溶剂， 反应 73.5h， 生成 (20S)-des-A,B-20-[4-(tert-butyldimethylsilyl)oxybutyl]pregnan-8-one
  参考文献：
  名称：

  26- and 27-Methyl groups of 2-substituted, 19-nor-1α,25-dihydroxylated vitamin D compounds are essential for calcium mobilization in vivo

  摘要：

  Twelve new analogs of 19-nor-1 alpha,25-dihydroxyvitamin D-3 6-17, were prepared by a multi-step procedure from known alcohols 18 and 19. We have examined the influence of removing two methyl groups located at C-25, as well as the 25-hydroxy group, on the biological in vitro and in vivo biological activity. Surprisingly, removal of the 26- and 27-methyl groups from either the 2 alpha-methyl or 2-methylene-19-nor-1 alpha,25-dihydroxyvitamin D-3 reduced vitamin D receptor binding, HL-60 differentiation, and 25-hydroxylase transcription in vitro only slightly to moderately (compounds 6-13). However, these compounds were devoid of in vivo bone mobilization activity and had markedly reduced activity on intestinal calcium transport. The analogs 14-17 with a 2 beta-methyl substitution had little or no activity in vitro and in vivo as expected from previous work. (C) 2013 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.bioorg.2013.01.001

文献信息

• WO2006/119309
  申请人：——

  公开号：——

  公开（公告）日：——
• 26- and 27-Methyl groups of 2-substituted, 19-nor-1α,25-dihydroxylated vitamin D compounds are essential for calcium mobilization in vivo
  作者：Pawel Grzywacz、Lori A. Plum、Margaret Clagett-Dame、Hector F. DeLuca

  DOI：10.1016/j.bioorg.2013.01.001

  日期：2013.4

  Twelve new analogs of 19-nor-1 alpha,25-dihydroxyvitamin D-3 6-17, were prepared by a multi-step procedure from known alcohols 18 and 19. We have examined the influence of removing two methyl groups located at C-25, as well as the 25-hydroxy group, on the biological in vitro and in vivo biological activity. Surprisingly, removal of the 26- and 27-methyl groups from either the 2 alpha-methyl or 2-methylene-19-nor-1 alpha,25-dihydroxyvitamin D-3 reduced vitamin D receptor binding, HL-60 differentiation, and 25-hydroxylase transcription in vitro only slightly to moderately (compounds 6-13). However, these compounds were devoid of in vivo bone mobilization activity and had markedly reduced activity on intestinal calcium transport. The analogs 14-17 with a 2 beta-methyl substitution had little or no activity in vitro and in vivo as expected from previous work. (C) 2013 Elsevier Inc. All rights reserved.