2-吡啶硫酸二甲酯肟 | 1200-55-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2-吡啶硫酸二甲酯肟
• 中文别名: [(E)-(1-甲基吡啶-2-亚基)甲基]-氧铵硫酸甲酯盐
• 英文名称: 2-[(hydroxyimino)methyl]-1-methylpyridinium methyl sulfate
• 英文别名: Pralidoxime methyl sulfate；(NE)-N-[(1-methylpyridin-1-ium-2-yl)methylidene]hydroxylamine;methyl sulfate
• CAS: 1200-55-1
• 化学式: CH₃O₄S*C₇H₉N₂O
• 分子量: 248.26
• InChiKey: OVPHBYQAKDEEBD-UHFFFAOYSA-N

物化性质

• 熔点：
  111-112.5 °C

计算性质

• 辛醇/水分配系数(LogP)：
  -0.59
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  111
• 氢给体数：
  1
• 氢受体数：
  6

安全信息

• 海关编码：
  2933399090

文献信息

• PHARMACEUTICAL COMPOSITION FOR TREATMENT OF SYNAPTIC DYSFUNCTION COMPRISING AN OXIME
  申请人：Synapse Pharmaceuticals International, Inc.

  公开号：EP1014981A1

  公开（公告）日：2000-07-05
• Methods and compositions for treatment of organophosphate-caused pathology
  申请人：Zoltani Csaba K.

  公开号：US20100168030A1

  公开（公告）日：2010-07-01

  A method of treating an organophosphate toxin-caused cardiac abnormality is described which includes administering a pharmaceutical composition including a therapeutically effective amount of a chloride current modulator to an individual subject having a cardiac abnormality caused by intoxication with an organophosphate toxin. The chloride current modulator is effective to modulate a chloride conductance and thereby reduce a symptom or sign of an organophosphate toxin-caused cardiac abnormality, thus treating the toxin-caused cardiac abnormality. Optionally, included is administering a therapeutic agent to inhibit an organophosphate toxin-caused distortion of the action potential of myocytes, support restoration of usual intracellular ionic concentrations, and support an increase in cardiac contractility. A composition according to the invention is described which includes a chloride current modulator; and a therapeutic agent to inhibit an organophosphate toxin-induced distortion of the action potential of myocytes, support restoration of usual intracellular ionic concentrations, and support an increase in cardiac contractility.
• US5760049A
  申请人：——

  公开号：US5760049A

  公开（公告）日：1998-06-02
• US5824684A
  申请人：——

  公开号：US5824684A

  公开（公告）日：1998-10-20
• US5900418A
  申请人：——

  公开号：US5900418A

  公开（公告）日：1999-05-04