2-Hexadecylpyridine | 50972-70-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-Hexadecylpyridine
• CAS: 50972-70-8
• 化学式: C₂₁H₃₇N
• 分子量: 303.5
• InChiKey: DJIOGHZNVKFYHH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.8
• 重原子数：
  22
• 可旋转键数：
  15
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] POLYAMINE INHIBITORS FOR THE TREATMENT AND PREVENTION OF PARKINSON'S DISEASE<br/>[FR] INHIBITEUR DE POLYAMINE POUR LE TRAITEMENT ET LA PRÉVENTION DE LA MALADIE DE PARKINSON
  申请人：UNIV COLUMBIA

  公开号：WO2010098886A1

  公开（公告）日：2010-09-02

  Disclosed herein are methods for treating a disease involving α-synucleic aggregation using (1) a compound which reduces the amount of polyamines in an amount effective to reduce α-synucleic aggregation; (2) a compound which inhibits polyamine synthesis in an amount effective to reduce α-synucleic aggregation; or (3) a compound which inhibits α- synucleic aggregation in an amount effective to reduce α-synucleic aggregation. Also disclosed are methods for reducing the amount of α-synucleic aggregation in a brain cell using (1) a compound which reduces the amount of polyamines in an amount effective to reduce α-synucleic aggregation; (2) a compound which inhibits polyamine synthesis in an amount effective to reduce α-synucleic aggregation; or (3) a compound which inhibits α-synucleic aggregation in an amount effective to reduce α-synucleic aggregation. Disclosed herein are also compounds which can be used in the above described methods.

  本文揭示了治疗涉及α-突触核聚集的疾病的方法，使用以下物质之一：（1）减少多胺量的化合物，以有效减少α-突触核聚集；（2）抑制多胺合成的化合物，以有效减少α-突触核聚集；或（3）抑制α-突触核聚集的化合物，以有效减少α-突触核聚集。还揭示了一种在脑细胞中减少α-突触核聚集量的方法，使用以下物质之一：（1）减少多胺量的化合物，以有效减少α-突触核聚集；（2）抑制多胺合成的化合物，以有效减少α-突触核聚集；或（3）抑制α-突触核聚集的化合物，以有效减少α-突触核聚集。本文还揭示了可用于上述方法的化合物。
• SMALL MOLECULE CMKLR1 ANTAGONISTS IN INFLAMMATORY DISEASE
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：US20200345661A1

  公开（公告）日：2020-11-05

  α-NETA analogs are provided for the treatment of inflammatory disease.

  α-NETA类似物用于治疗炎症性疾病。
• Compositions and Methods Comprising Carboxylic Acid-Containing Small Molecules
  申请人：University of Central Florida Research Foundation, Inc.

  公开号：US20150087605A1

  公开（公告）日：2015-03-26

  Disclosed are compositions and methods for treating anthrax, inhibiting anthrax toxins and inhibiting anthrax toxin-induced cytotoxicity. Carboxylic acid-containing small molecules can be used in the methods and compositions disclosed herein, for example, sulindac and derivatives thereof may be used. Methods of screening for carboxylic acid-containing small molecules that can be used to treat anthrax are disclosed. Targeting the anthrax toxin reduces the risks of anthrax spores.

  本文揭示了用于治疗炭疽病、抑制炭疽毒素以及抑制炭疽毒素诱导的细胞毒性的组合物和方法。可以在此披露的方法和组合物中使用含有羧酸的小分子，例如，可以使用硫酸卢卡因和其衍生物。还披露了筛选可用于治疗炭疽病的含有羧酸的小分子的方法。针对炭疽毒素可以降低炭疽孢子的风险。
• Oxabicycloheptanes and oxabicylcoheptenes, their preparation and use
  申请人：Kovach John S.

  公开号：US20090036309A1

  公开（公告）日：2009-02-05

  This invention provides compounds having the structure which may be used for the treatment of tumors.

  这项发明提供了具有该结构的化合物，可用于肿瘤治疗。
• COMPOSITION AND METHOD FOR CANCER TREATMENT AND PREVENTION
  申请人：Liao Heather H.

  公开号：US20080261898A1

  公开（公告）日：2008-10-23

  Compounds, compositions, methods and kits are provided for treating, reducing the risk of, or preventing diseases and/or conditions, such as diseases associated with angiogenesis and/or abnormal cell proliferation, such as cancer. Compounds of the present invention have antiangiogenic and anti-cancer activity with minimum toxic effects on normal cells. Methods for preparing and manufacturing the compounds and pharmaceutical compositions are also provided.

  提供了用于治疗、减少风险或预防与血管生成和/或异常细胞增殖有关的疾病和/或疾病的化合物、组合物、方法和试剂盒，如癌症。本发明的化合物具有抗血管生成和抗癌活性，对正常细胞的毒性作用最小。还提供了制备和生产这些化合物及药物组合物的方法。