4-[[4-[[(4E)-5-[-4-(dimethylamino)phenyl]-4-pentenyl]oxy]phenyl]sulfonyl]tetrahydro-N-hydroxy-2H-pyran-4-carboxamide | 476187-65-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[[4-[[(4E)-5-[-4-(dimethylamino)phenyl]-4-pentenyl]oxy]phenyl]sulfonyl]tetrahydro-N-hydroxy-2H-pyran-4-carboxamide
• 英文别名: 4-[4-[(E)-5-[4-(dimethylamino)phenyl]pent-4-enoxy]phenyl]sulfonyl-N-hydroxyoxane-4-carboxamide
• CAS: 476187-65-2
• 化学式: C₂₅H₃₂N₂O₆S
• 分子量: 488.605
• InChiKey: LCJGUPYTXBMOHB-GQCTYLIASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  34
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  114
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  O-(四氢-2H-吡喃-2-基)羟基胺 、 2,2,2-trifluoroacetic acid compound with 4-((4-((5-(4-(dimethylamino)phenyl)pent-4-en-1-yl)oxy)phenyl)sulfonyl)tetrahydro-2H-pyran-4-carboxylic acid (1:1) 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 、 三氟乙酸 作用下， 以 DMF (N,N-dimethyl-formamide) 、 水 为溶剂， 反应 24.0h， 以2%的产率得到4-[[4-[[(4Z)-5-[-4-(dimethyl-amino)phenyl]-4-pentenyl]oxy]phenyl]sulfonyl]tetrahydro-N-hydroxy-2H-pyran-4-carboxamide monohydrochloride
  参考文献：
  名称：

  Aromatic sulfone hydroxamates and their use as protease inhibitors

  摘要：

  这项发明涉及芳香砜羟肟酸酯（也称为“芳香砜羟肟酸”）及其盐，该化合物在抑制基质金属蛋白酶（也称为“基质金属蛋白酶”或“MMP”）活性和/或聚集素酶活性方面具有作用。该发明还涉及一种预防或治疗方法，包括向动物，特别是患有（或易患）与MMP和/或聚集素酶活性相关的病理状况的哺乳动物，施用此类化合物或盐以达到抑制MMP和/或聚集素酶的有效量。

  公开号：

  US20040010019A1

文献信息

• [EN] AROMATIC SULFONE HYDROXAMIC ACIDS AND THEIR USE AS PROTEASE INHIBITORS<br/>[FR] ACIDES HYDROXAMIQUES SULFONIQUES AROMATIQUES ET LEUR UTILISATION COMME INHIBITEURS DE LA PROTEASE
  申请人：PHARMACIA CORP

  公开号：WO2004043943A1

  公开（公告）日：2004-05-27

  This invention is directed to aromatic sulfone hydroxamic acids (including aromatic sulfone hydroxamates) and salts thereof that, inter alia, inhibit matrix metalloproteinase (also known as 'matrix metalloprotease' or 'MMP') activity and/or aggrecanase activity. This invention also is directed to a prevention or treatment method that comprises administering such a compound or salt in an MMP-inhibiting and/or aggrecanase-inhibiting effective amount to an animal, particularly a mammal having (or disposed to having) a pathological condition associated with MMP and/or aggrecanase activity.
• Aromatic sulfone hydroxamates and their use as protease inhibitors
  申请人：——

  公开号：US20040010019A1

  公开（公告）日：2004-01-15

  This invention is directed to aromatic sulfone hydroxamates (also known as “aromatic sulfone hydroxamic acids”) and salts thereof that, inter alia, inhibit matrix metalloproteinase (also known as “matrix metalloprotease” or “MMP”) activity and/or aggrecanase activity. This invention also is directed to a prevention or treatment method that comprises administering such a compound or salt in an MMP-inhibiting and/or aggrecanase-inhibiting effective amount to an animal, particularly a mammal having (or disposed to having) a pathological condition associated with MMP and/or aggrecanase activity.

  这项发明涉及芳香砜羟肟酸酯（也称为“芳香砜羟肟酸”）及其盐，该化合物在抑制基质金属蛋白酶（也称为“基质金属蛋白酶”或“MMP”）活性和/或聚集素酶活性方面具有作用。该发明还涉及一种预防或治疗方法，包括向动物，特别是患有（或易患）与MMP和/或聚集素酶活性相关的病理状况的哺乳动物，施用此类化合物或盐以达到抑制MMP和/或聚集素酶的有效量。