l'acide 2-ethoxy-2-diethylphosphonoacetique | 30094-30-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: l'acide 2-ethoxy-2-diethylphosphonoacetique
• 英文别名: (+/-)-Ethoxy-α-diethylphosphono-essigsaeure；α-Diaethylphosphono-aethoxyessigsaeure；2-Diethoxyphosphoryl-2-ethoxyacetic acid
• CAS: 30094-30-5
• 化学式: C₈H₁₇O₆P
• 分子量: 240.193
• InChiKey: BBOYXTFZIZCVGG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  15
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  82.1
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1,2：3,4-二-O-异亚丙基-α-D-半乳糖-己二醛-1,5-吡喃糖 、 l'acide 2-ethoxy-2-diethylphosphonoacetique 在 正丁基锂 作用下， 生成 (E)-2-Ethoxy-3-((3aR,5R,5aS,8aS,8bR)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-yl)-acrylic acid
  参考文献：
  名称：

  Coutrot, Philippe; Grison, Claude; Lecouvey, Marc, Bulletin de la Societe Chimique de France, 1997, vol. 134, # 1, p. 27 - 46

  摘要：

  DOI：
• 作为产物：
  描述：

  2-乙氧基三乙基磷酸乙酯 在 potassium carbonate 作用下， 以 水 为溶剂， 反应 0.17h， 生成 l'acide 2-ethoxy-2-diethylphosphonoacetique
  参考文献：
  名称：

  Coutrot, Philippe; Grison, Claude; Lecouvey, Marc, Phosphorus, Sulfur and Silicon and the Related Elements, 1994, vol. 97, # 1-4, p. 47 - 56

  摘要：

  DOI：

文献信息

• Stereoselective synthesis of vinylogous peptides
  作者：Claude Grison、Stéphane Genève、Etienne Halbin、Philippe Coutrot

  DOI：10.1016/s0040-4020(01)00433-1

  日期：2001.6

  A trans or cis ethenyl group has been inserted between the α-carbon and the carboxyl group of α-aminoacids by Horner stereoselective olefination of α-aminoaldehydes. Numerous pure cis and trans vinylogous α-aminoacids have been obtained thus and coupled with aminopartners by classical methods. The versatility of the method was illustrated by the preparation of a [trans vinylogous-Gly3]Leu-enkephalin

  通过α-氨基醛的霍纳立体选择性烯化，将反式或顺式乙烯基插入α-氨基酸的α-碳和羧基之间。因此已经获得了许多纯的顺式和反式乙烯基α-氨基酸，并通过经典方法与氨基配偶体偶联。该方法的多功能性通过制备[反式乙烯基-Gly 3 ]亮脑啡肽来说明。
• New heterocyclic oxime compounds
  申请人：Leclerc Veronique

  公开号：US20050026973A1

  公开（公告）日：2005-02-03

  Compounds of formula (I): wherein: X represents oxygen or sulphur or a group CH 2 or R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined in the description, A represents an alkylene chain as defined in the description, B represents alkyl or alkenyl substituted by a group or R 9 , or B represents a group or R 9 , D represents a benzene, pyridine, pyrazine, pyrimidine or pyridazine nucleus. Medicaments

  式(I)的化合物：其中：X代表氧或硫或基团CH2或R1、R2、R3、R4、R5和R6如描述中所定义，A代表描述中所定义的烷基链，B代表被基团或R9取代的烷基或烯基，或者B代表基团或R9，D代表苯、吡啶、吡嗪、嘧啶或吡啉核。药物
• NOVEL BIAROMATIC COMPOUNDS THAT MODULATE PPAR-RECEPTORS
  申请人：Boiteau Jean-Guy

  公开号：US20090012129A1

  公开（公告）日：2009-01-08

  Novel biaromatic compounds that modulate peroxisome proliferator-activator receptors, known as PPAR, having the formula (I): are formulated into pharmaceutical compositions useful in human or veterinary medicine, or alternatively, in cosmetic compositions.

  将调节过氧化物酶增殖激活受体（PPAR）的新型双芳香化合物配方（I）制成药用组合物，可用于人类或兽医医学，或者用于化妆品组合物。
• Novel compounds that modulate PPARy type receptors and cosmetic/pharmaceutical compositions comprised thereof
  申请人：Clary Laurence

  公开号：US20060148862A1

  公开（公告）日：2006-07-06

  Novel compounds having the general formula (I) below: are useful in a wide variety of applications in human or veterinary medicine (in dermatology, and also in the fields of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or, alternatively are formulated into cosmetic compositions.

  具有以下一般式（I）的新化合物在人类或兽医学中具有广泛的应用（在皮肤病学中，以及在心血管疾病、免疫疾病和/或与脂质代谢有关的疾病领域），或者被制成化妆品组合物。
• METHODS OF MODULATING PPAR GAMMA-TYPE RECEPTORS
  申请人：CLARY Laurence

  公开号：US20100099689A1

  公开（公告）日：2010-04-22

  Novel compounds having the general formula (I) below: are useful in a wide variety of applications in human or veterinary medicine (in dermatology, and also in the fields of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or, alternatively are formulated into cosmetic compositions.

  具有以下一般式（I）的新化合物在人类或兽医学中具有广泛的应用（在皮肤科以及心血管疾病、免疫疾病和/或与脂质代谢相关的疾病领域），或者被制成化妆品组合物。