Methyl 2-phenyl-2-[(2,2,2-trichloroacetyl)carbamoyloxy]acetate | 1123071-70-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Methyl 2-phenyl-2-[(2,2,2-trichloroacetyl)carbamoyloxy]acetate
• 英文别名: methyl 2-phenyl-2-[(2,2,2-trichloroacetyl)carbamoyloxy]acetate
• CAS: 1123071-70-4
• 化学式: C₁₂H₁₀Cl₃NO₅
• 分子量: 354.574
• InChiKey: GIPSZHMMJGGISP-UHFFFAOYSA-N

物化性质

• 密度：
  1.501±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  81.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Methyl 2-phenyl-2-[(2,2,2-trichloroacetyl)carbamoyloxy]acetate 以 乙醇 为溶剂， 生成 Methyl 2-carbamoyloxy-2-phenylacetate
  参考文献：
  名称：

  通过使用三氯乙酰基异氰酸酯从α-羟基酯原位生成氨基甲酸酯，轻松进行一锅法合成3-未取代的2,4-恶唑烷二酮

  摘要：

  描述了一种方便，高产率的一锅法，用于从α-羟基酯合成可药用的3-un取代的2,4-恶唑烷二酮。由相应的α-羟基酯和三氯乙酰基异氰酸酯原位生成伯氨基甲酸酯，然后通过分子内闭环将其转化为所需的3-未取代的2,4-恶唑烷二酮。该方法适合扩大规模，无需色谱纯化。

  DOI：

  10.1016/j.tetlet.2008.11.124
• 作为产物：
  描述：

  5-aminoallyl-UTP 在 三氯乙酸 作用下， 以 二氯甲烷 为溶剂， 生成 Methyl 2-phenyl-2-[(2,2,2-trichloroacetyl)carbamoyloxy]acetate
  参考文献：
  名称：

  Solid-phase synthesis of new ribo and deoxyribo BrdU probes for labeling and detection of nucleic acids

  摘要：

  A facile and efficient solid-phase synthesis of BrdU-14-UTP and BrdU-14-dUTP is reported. The method involves a nucleophilic addition of CPG-supportecl Br-dU with a T-carboxy modifier amidite, followed by the coupling with AA-UTP or AA-dUTP and finally the solid-support is cleaved under basic conditions. The newly prepared non-radioactive probes may have important applications in immunocytochemistry spatially in labeling and detection assays. BrdU moiety is coupled with nucleotides like dUTP and UTP and incorporated into nucleic acids using generally available polymerase like Taq polymerase or RNA polymerase. The probes thus generated can be used in standard blotting and hybridization procedures including in situ hybridization and detection with anti-BrdU conjugates. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.11.122

文献信息

• A facile one-pot synthesis of 3-unsubstituted-2,4-oxazolidinediones via in situ generation of carbamates from α-hydroxyesters using trichloroacetyl isocyanate
  作者：Yue H. Li、Li Zhang、Pei-San Tseng、Yongliang Zhang、Yu Jin、Jingkang Shen、Jian Jin

  DOI：10.1016/j.tetlet.2008.11.124

  日期：2009.2

  methodology for the synthesis of pharmaceutically interesting 3-unsubstituted-2,4-oxazolidinediones from α-hydroxyesters is described. A primary carbamate was generated in situ from the corresponding α-hydroxyester and trichloroacetyl isocyanate, then converted to the desired 3-unsubstituted 2,4-oxazolidinedione via intramolecular ring closure. This method is amenable to scale-up and requires no chromatographic

  描述了一种方便，高产率的一锅法，用于从α-羟基酯合成可药用的3-un取代的2,4-恶唑烷二酮。由相应的α-羟基酯和三氯乙酰基异氰酸酯原位生成伯氨基甲酸酯，然后通过分子内闭环将其转化为所需的3-未取代的2,4-恶唑烷二酮。该方法适合扩大规模，无需色谱纯化。
• Solid-phase synthesis of new ribo and deoxyribo BrdU probes for labeling and detection of nucleic acids
  作者：Anilkumar R. Kore

  DOI：10.1016/j.tetlet.2008.11.122

  日期：2009.2

  A facile and efficient solid-phase synthesis of BrdU-14-UTP and BrdU-14-dUTP is reported. The method involves a nucleophilic addition of CPG-supportecl Br-dU with a T-carboxy modifier amidite, followed by the coupling with AA-UTP or AA-dUTP and finally the solid-support is cleaved under basic conditions. The newly prepared non-radioactive probes may have important applications in immunocytochemistry spatially in labeling and detection assays. BrdU moiety is coupled with nucleotides like dUTP and UTP and incorporated into nucleic acids using generally available polymerase like Taq polymerase or RNA polymerase. The probes thus generated can be used in standard blotting and hybridization procedures including in situ hybridization and detection with anti-BrdU conjugates. (C) 2008 Elsevier Ltd. All rights reserved.