2-异丙基-6-甲基喹喔啉 | 149179-66-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 中文名称: 2-异丙基-6-甲基喹喔啉
• 英文名称: 2-Isopropyl-6-methylquinoxaline
• 英文别名: 6-methyl-2-propan-2-ylquinoxaline
• CAS: 149179-66-8
• 化学式: C₁₂H₁₄N₂
• 分子量: 186.257
• InChiKey: RXPHJNVIGAJPTA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-叠氮基-4-甲基-2-硝基苯 在 palladium on activated charcoal 氢气 、 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 乙醇 、 苯 为溶剂， 25.0 ℃ 、101.33 kPa 条件下， 反应 4.0h， 生成 2-异丙基-6-甲基喹喔啉
  参考文献：
  名称：

  Battistini, Maurizio; Erba, Emanuela; Pocar, Donato, Journal of the Chemical Society. Perkin transactions I, 1993, # 3, p. 339 - 342

  摘要：

  DOI：

文献信息

• Bicyclic aromatic substituted pyridone derivative
  申请人：Sakuraba Shunji

  公开号：US20090264426A1

  公开（公告）日：2009-10-22

  Disclosed is a compound represented by the formula (I): Wherein R 1 and R 2 independently represent a hydrogen atom, a lower alkyl group or the like; X 1 , X 2 and X 3 independently represent a methine group or a nitrogen atom; Y 1 and Y 3 independently represent a single bond, —O— or the like; Y 2 represents a lower alkylene group or the like; W1 to W4 independently represent a single bond, a methylene group or the like; L represents a single bond, a methylene group or the like; Z 1 and Z 2 independently represent a single bond, a C 1-4 alkylene group or the like; Ar 1 represents an aromatic carbocyclic ring or the like; and Ar 2 represents a bicyclic aromatic carbocyclic ring or the like. The compound is useful as a pharmaceutical for a central disease, a cardiovascular disease or a metabolic disease.

  本发明揭示了一种化合物，其化学式为（I）：其中R1和R2分别代表氢原子、低碳烷基或类似物；X1、X2和X3分别代表亚甲基基团或氮原子；Y1和Y3分别代表单键、—O—或类似物；Y2代表低碳烷基基团或类似物；W1至W4独立地代表单键、亚甲基基团或类似物；L代表单键、亚甲基基团或类似物；Z1和Z2独立地代表单键、C1-4烷基基团或类似物；Ar1代表芳香环烷基环或类似物；Ar2代表双环芳香环烷基环或类似物。该化合物可用作治疗中枢疾病、心血管疾病或代谢性疾病的药物。
• Battistini Maurizio, Erba Emanuela, Pocar Donato, J. Chem. Soc. Perkin Trans. 1, (1993) N 3, S 339-342
  作者：Battistini Maurizio, Erba Emanuela, Pocar Donato

  DOI：——

  日期：——
• Antibacterial Compounds
  申请人：Janssen Sciences Ireland UC

  公开号：US20180155341A1

  公开（公告）日：2018-06-07

  The present invention relates to the following compounds wherein the integers are as defined in the description, and where the compounds may be useful as medicaments, for instance for use in the treatment of tuberculosis.
• [EN] ISOXAZOLE ANALOGS AS FXR AGONISTS AND METHODS OF USE THEREOF<br/>[FR] ANALOGUES DE L'ISOXAZOLE EN TANT QU'AGONISTES DE FXR ET LEURS PROCÉDÉS D'UTILISATION
  申请人：ENANTA PHARM INC

  公开号：WO2018067704A1

  公开（公告）日：2018-04-12

  The present invention provides compounds of Formula I, pharmaceutical compositions comprising these compounds and methods of using these compounds to prevent or treat FXR-mediated or TGR5-mediated diseases or conditions.
• [EN] ISOXAZOLE ANALOGS AS FXR AGONISTS AND METHODS OF USE THEREOF<br/>[FR] ANALOGUES DE L'ISOXAZOLE UTILISÉS EN TANT QU'AGONISTES DE FXR ET LEURS PROCÉDÉS D'UTILISATION
  申请人：ENANTA PHARM INC

  公开号：WO2019118571A1

  公开（公告）日：2019-06-20

  The present invention provides compounds of Formula (I), and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising these compounds and methods of using these compounds to prevent or treat FXR-mediated or TGR5-mediated diseases or conditions.