1,7-bis(diethylamino)-4-aminoheptane | 1020170-69-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1,7-bis(diethylamino)-4-aminoheptane
• 英文别名: 1-N,1-N,7-N,7-N-tetraethylheptane-1,4,7-triamine
• CAS: 1020170-69-7
• 化学式: C₁₅H₃₅N₃
• 分子量: 257.463
• InChiKey: ZHCMUZHVEMGBQJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  18
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4,7-二氯喹啉 、 1,7-bis(diethylamino)-4-aminoheptane 反应 72.0h， 以0.04 g的产率得到N-(7-氯-4-喹啉基)-1,7-双(二乙氨基)-4-氨基庚烷
  参考文献：
  名称：

  Overcoming Drug Resistance to Heme-Targeted Antimalarials by Systematic Side Chain Variation of 7-Chloro-4-aminoquinolines

  摘要：

  Systematic variation of the branching and basicity of the side chain of chloroquine yielded a series of new 7-chloro-4-aminoquinoline derivatives exhibiting high in vitro activity against four different strains of P. falciparum. Many of the compounds tested showed excellent potency against chloroquine sensitive and resistant strains. In particular 4b, 5a, 5b, 5d, 17a, and 17b were found to be significantly more potent than chloroquine against the resistant strains Dd2 and FCB.

  DOI：

  10.1021/jm800106u
• 作为产物：
  描述：

  4-酮庚二酸 在 lithium aluminium tetrahydride 、 ammonium acetate 、 benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate 、 sodium cyanoborohydride 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 甲醇 、 甲苯 、 乙腈 为溶剂， 反应 132.0h， 生成 1,7-bis(diethylamino)-4-aminoheptane
  参考文献：
  名称：

  [EN] ANTIMALARIAL QUINOLINES AND METHODS OF USE THEREOF
  [FR] QUINOLÉINES ANTIPALUDIQUES ET LEURS PROCÉDÉS D'UTILISATION

  摘要：

  公开号：

  WO2009148659A3

文献信息

• Antimalarial Quinolines and Methods of Use Thereof
  申请人：Wolf Christian

  公开号：US20110045100A1

  公开（公告）日：2011-02-24

  One aspect of the invention relates to substitute quinolines with antimalarial activity, and compositions and kits comprising at least one of them. Another aspect of the invention relates to methods for the treatment or prevention or both of malaria comprising administering to a subject a therapeutically effective amount of such a compound. Importantly, a number of the compounds show excellent potency against both chloroquine-sensitive and chloroquine-resistant strains.

  本发明的一个方面涉及具有抗疟活性的替代喹啉，以及包含至少其中之一的组合物和试剂盒。另一个方面涉及用这种化合物向受试者施用治疗有效量的方法，以治疗或预防疟疾。重要的是，其中一些化合物对氯喹敏感和氯喹耐药菌株都表现出极高的效力。
• [EN] ANTIMALARIAL QUINOLINES AND METHODS OF USE THEREOF<br/>[FR] QUINOLÉINES ANTIPALUDIQUES ET LEURS PROCÉDÉS D'UTILISATION
  申请人：UNIV GEORGETOWN

  公开号：WO2009148659A3

  公开（公告）日：2010-02-25
• Overcoming Drug Resistance to Heme-Targeted Antimalarials by Systematic Side Chain Variation of 7-Chloro-4-aminoquinolines
  作者：Kimberly Yearick、Kekeli Ekoue-Kovi、Daniel P. Iwaniuk、Jayakumar K. Natarajan、John Alumasa、Angel C. de Dios、Paul D. Roepe、Christian Wolf

  DOI：10.1021/jm800106u

  日期：2008.4.1

  Systematic variation of the branching and basicity of the side chain of chloroquine yielded a series of new 7-chloro-4-aminoquinoline derivatives exhibiting high in vitro activity against four different strains of P. falciparum. Many of the compounds tested showed excellent potency against chloroquine sensitive and resistant strains. In particular 4b, 5a, 5b, 5d, 17a, and 17b were found to be significantly more potent than chloroquine against the resistant strains Dd2 and FCB.