2'-O-(3-biotinamido)propyl-6-chloropurine-9-β-D-ribofuranoside-5'-monophosphate | 1290042-53-3

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 英文名称: 2'-O-(3-biotinamido)propyl-6-chloropurine-9-β-D-ribofuranoside-5'-monophosphate
• 英文别名: 6-Cl-PRT-biotin；[(2R,3R,4R,5R)-4-[3-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]propoxy]-5-(6-chloropurin-9-yl)-3-hydroxyoxolan-2-yl]methyl dihydrogen phosphate
• CAS: 1290042-53-3
• 化学式: C₂₃H₃₃ClN₇O₉PS
• 分子量: 650.049
• InChiKey: SFONFULQJBIUSQ-BRKQVYTGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  42
• 可旋转键数：
  14
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  245
• 氢给体数：
  6
• 氢受体数：
  13

反应信息

• 作为产物：
  描述：

  1,3,5-tri-O-acetyl-2-O-(3-trifluoroacetamido)propyl-D-ribofuranoside 在 甲醇 、 三甲基氯硅烷 、 三氟甲磺酸三甲基硅酯 、 sodium carbonate 、 三乙胺 、 六甲基二硅氮烷 、 三氯氧磷 作用下， 以 水 、 二甲基亚砜 、 乙腈 为溶剂， 反应 14.5h， 生成 2'-O-(3-biotinamido)propyl-6-chloropurine-9-β-D-ribofuranoside-5'-monophosphate
  参考文献：
  名称：

  Specific biotinylation of IMP dehydrogenase

  摘要：

  IMP dehydrogenase (IMPDH) catalyzes a critical step in guanine nucleotide biosynthesis. IMPDH also has biological roles that are distinct from its enzymatic function. We report a biotin-linked reagent that selectively labels IMPDH and is released by dithiothreitol. This reagent will be invaluable in elucidating the moonlighting functions of IMPDH. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.01.042

文献信息

• Specific biotinylation of IMP dehydrogenase
  作者：B. Christopher Hoefler、Deviprasad R. Gollapalli、Lizbeth Hedstrom

  DOI：10.1016/j.bmcl.2011.01.042

  日期：2011.3

  IMP dehydrogenase (IMPDH) catalyzes a critical step in guanine nucleotide biosynthesis. IMPDH also has biological roles that are distinct from its enzymatic function. We report a biotin-linked reagent that selectively labels IMPDH and is released by dithiothreitol. This reagent will be invaluable in elucidating the moonlighting functions of IMPDH. (C) 2011 Elsevier Ltd. All rights reserved.