(1,1-Diethoxybutyl)-3-diphenylphosphine oxide | 141206-84-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (1,1-Diethoxybutyl)-3-diphenylphosphine oxide
• 英文别名: [4,4-Diethoxybutan-2-yl(phenyl)phosphoryl]benzene
• CAS: 141206-84-0
• 化学式: C₂₀H₂₇O₃P
• 分子量: 346.406
• InChiKey: ULZWMXFSRPNLNL-UHFFFAOYSA-N

物化性质

• 沸点：
  438.5±35.0 °C(Predicted)
• 密度：
  1.08±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  24
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  methyl N-(2-chloro-5-formyl-3-methoxyphenyl)-N-methylcarbamate 、 (1,1-Diethoxybutyl)-3-diphenylphosphine oxide 生成 Carbamic acid,[2-chloro-5-(4,4-diethoxy-2-methyl-1-butenyl)-3-methoxyphenyl]methyl-,methyl ester, (E)-
  参考文献：
  名称：

  Total synthesis of maytansinoids. Approach to 4,6-bisdemethylmaytansine and 4-demethylmaytansine

  摘要：

  A convergent strategy was elaborated to synthesize maytansine 1 and maytansinoids modified on the carbon skeleton, especially 4-demethylmaytansine 2, 6-demethylmaytansine 3, 4,6-bisdemethylmaytansine 4. In this paper, the feasibility of the project was verified by the preparation of key intermediates for the synthesis of 4, 6-bisdemethylmaytansine and 6-demethylmaytansine. The C-1-N open chain compound 18 in the 4,6-bisdemethyl series was obtained.

  DOI：

  10.1016/s0040-4020(01)88513-6
• 作为产物：
  描述：

  3-氯丁醛二乙基缩醛 、 二苯基氯化膦 生成 (1,1-Diethoxybutyl)-3-diphenylphosphine oxide
  参考文献：
  名称：

  Total synthesis of maytansinoids. Approach to 4,6-bisdemethylmaytansine and 4-demethylmaytansine

  摘要：

  A convergent strategy was elaborated to synthesize maytansine 1 and maytansinoids modified on the carbon skeleton, especially 4-demethylmaytansine 2, 6-demethylmaytansine 3, 4,6-bisdemethylmaytansine 4. In this paper, the feasibility of the project was verified by the preparation of key intermediates for the synthesis of 4, 6-bisdemethylmaytansine and 6-demethylmaytansine. The C-1-N open chain compound 18 in the 4,6-bisdemethyl series was obtained.

  DOI：

  10.1016/s0040-4020(01)88513-6