2,5-Dibrom-1-t-butylbenzol | 6683-77-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,5-Dibrom-1-t-butylbenzol
• 英文别名: 1,4-Dibromo-2-tert-butylbenzene
• CAS: 6683-77-8
• 化学式: C₁₀H₁₂Br₂
• 分子量: 292.013
• InChiKey: DKGIVQCPGPHLKD-UHFFFAOYSA-N

物化性质

• 熔点：
  42.5-44.0 °C
• 沸点：
  258.6±20.0 °C(Predicted)
• 密度：
  1.549±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  2-叔丁基-4-硝基苯胺 生成 2,5-Dibrom-1-t-butylbenzol
  参考文献：
  名称：

  Baas,J.M.A.; Wepster,B.M., Recueil des Travaux Chimiques des Pays-Bas, 1966, vol. 85, p. 457 - 466

  摘要：

  DOI：

文献信息

• LIVER DELIVERY-BASED ANTIVIRAL PRECURSOR DRUG NUCLEOSIDE CYCLOPHOSPHATE COMPOUND AND USE THEREOF
  申请人：Zhejiang Paloalto Pharmaceutical Technology Co Ltd

  公开号：EP3476854A1

  公开（公告）日：2019-05-01

  Disclosed are a liver specific delivery (LSD)-based antiviral prodrug nucleoside cyclophosphate compound and uses thereof, and in particular, provided are a compound of formula (II), and an isomer, a pharmaceutically acceptable salt, a hydrate and a solvate thereof, and the corresponding pharmaceutical composition. The present invention also provides uses of the present compounds, alone or in combination with other antiviral drugs, in the treatment of the diseases caused by hepatitis B virus (HBV), hepatitis D virus (HDV) and human immunodeficiency virus (HIV).

  本发明公开了一种基于肝脏特异性递送（LSD）的抗病毒原药核苷环磷酸酯化合物及其用途，特别是提供了一种式（II）化合物及其异构体、药学上可接受的盐、水合物和溶液，以及相应的药物组合物。本发明还提供了本发明化合物单独或与其他抗病毒药物联合用于治疗乙型肝炎病毒（HBV）、丁型肝炎病毒（HDV）和人类免疫缺陷病毒（HIV）引起的疾病的用途。
• POLYARYLENE SULFIDE RESIN COMPOSITION
  申请人：——

  公开号：US20020062003A1

  公开（公告）日：2002-05-23

  Provided is a polyarylene sulfide resin composition having well-balanced fluidity and mechanical strength. The composition is such that its spiral flow length, x (mm), to give a molding having a thickness of 1 mm and the flexural strength, y (MPa), of the molding satisfy the following numerical formula (I), and comprises (A) from 50 to 70 parts by weight of a polyarylene sulfide resin, (B) from 30 to 50 parts by weight of glass fibers and (C) from 0 to 3 parts by weight, relative to 100 parts by weight of the polyarylene sulfide resin (A), of a coupling agent. y ≧−(3x/10)+340  (I) wherein x falls between 100 and 300.

  本发明提供了一种聚芳硫醚树脂组合物，其流动性和机械强度非常均衡。该组合物的螺旋流动长度 x（毫米）和厚度为 1 毫米的成型件的抗弯强度 y（兆帕）均满足下式(I)，并包含(A) 50 至 70 重量份的聚芳基硫醚树脂、(B) 30 至 50 重量份的玻璃纤维和(C) 0 至 3 重量份的偶联剂（相对于 100 重量份的聚芳基硫醚树脂 (A)）。 y ≧-(3x/10)+340 (I) 其中 x 介于 100 和 300 之间。
• Polyarylensulfide, polyarylensulfide resin composition, method for producing polyarylensulfide
  申请人：Idemitsu Kosan Co., Ltd.

  公开号：US20020128372A1

  公开（公告）日：2002-09-12

  Provided are a polyarylene sulfide having a chloroform soluble content of at most 0.5% by weight and having an inherent viscosity &eegr;inh of from 0.05 to 0.4; a polyarylene sulfide resin composition comprising a polyarylene sulfide and an inorganic filler, of which the chloroform soluble content is at most 0.5% by weight relative to the polyarylene sulfide in the composition; car parts produced through injection molding of the composition; and a method for producing a polyarylene sulfide. The polyarylene sulfide has a reduced content of low-molecular components, and has well balanced properties of fluidity, flexural strength and impact resistance.
• IMIDAZOLYL AMIDE COMPOUNDS AND USES RELATED THERETO
  申请人：Plemper Richard K.

  公开号：US20140080828A1

  公开（公告）日：2014-03-20

  This disclosure relates to antiviral compounds disclosed herein and uses related thereto. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising 2-((benzo[d]imidazol-2-yl)thio)-N-phenylpropanamide derivatives, N-phenyl-2-((1-phenyl-benzo[d]imidazol-2-yl)thio)propanamide derivatives, or 2-((benzo[d]imidazol-2-yl)thio)-N-(2-chloro-4-methylphenyl)propanamide derivatives. The derivatives may be substituted with one or more substituents. Typically, the pharmaceutical composition comprises a compound of Formula (I), or salt, prodrug, or ester thereof wherein X, Y, and R1 to R7 are described herein.
• US6388003B1
  申请人：——

  公开号：US6388003B1

  公开（公告）日：2002-05-14