N'-(3,5-dichloro-2-hydroxybenzylidene)-2-methylbenzohydrazide | 304479-88-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N'-(3,5-dichloro-2-hydroxybenzylidene)-2-methylbenzohydrazide
• 英文别名: N’-(3,5-dichloro-2-hydroxybenzylidene)-2-methylbenzohydrazide；N-[(3,5-dichloro-2-hydroxyphenyl)methylideneamino]-2-methylbenzamide
• CAS: 304479-88-7
• 化学式: C₁₅H₁₂Cl₂N₂O₂
• 分子量: 323.178
• InChiKey: WBUJSMRPJBTIGG-UHFFFAOYSA-N

物化性质

• 密度：
  1.35±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  61.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  甲醇 、 bis(acetylacetonate)oxovanadium 、 N'-(3,5-dichloro-2-hydroxybenzylidene)-2-methylbenzohydrazide 反应 0.5h， 生成
  参考文献：
  名称：

  Crystal structure and insulin-like activity of a vanadium complex derived from N′-(3,5-dichloro-2-hydroxybenzylidene)-2-methylbenzohydrazide

  摘要：

  Vanadium complexes have been proved to possess an interesting insulin-like activity. The reaction of VO(acac)(2) with N'-(3,5-dichloro-2-hydroxybenzylidene)-2-methylbenzohydrazide (H2L) in methanol affords a new mononuclear vanadium (V) complex [VOL(OMe)(MeOH)]. The structure of the complex is characterized by physicochemical methods and single crystal X-ray diffraction. The complex crystallizes as the monoclinic space group P2(1)/n, with unit cell parameters a = 7.830(2) , b = 23.225(3) , c = 10.635(2) , beta = 101.947(2)A degrees, V = 1892.1(6) (3), Z = 4, R (1) = 0.0404, wR (2) = 0.0953, S = 1.037. The X-ray analysis indicates that the V atom in the complex is in the octahedral coordination. The insulin-like activity of the complex is studied.

  DOI：

  10.1134/s002247661506027x
• 作为产物：
  描述：

  2-甲苯甲酰肼 、 3,5-二氯水杨醛 以 甲醇 为溶剂， 反应 0.5h， 以95%的产率得到N'-(3,5-dichloro-2-hydroxybenzylidene)-2-methylbenzohydrazide
  参考文献：
  名称：

  三齿Hy的二氧化钼（VI）配合物的合成，晶体结构和催化性能

  摘要：

  由N'-（5-氯-2-羟基苄叉基）-2-甲基苯并酰肼（H 2 L 1）和N'-（3,5）衍生的具有式[MoO 2 L（MeOH）]的新型二氧化钼（VI）配合物制备了-二氯-2-羟基亚苄基）-2-甲基苯并酰肼（H 2 L 2）。通过单晶X射线衍射法确定配合物的晶体和分子结构。两种配合物都通过元素分析和FT-IR光谱进一步表征。单晶X射线结构研究表明，L 1和L 2通过烯醇氧，酚氧和偶氮甲碱氮与MoO 2核配位。两个络合物中的Mo原子均为八面体配位。已经研究了使用PhIO和NaOCl作为氧化剂的配合物对苯乙烯环氧化的催化性能。

  DOI：

  10.17344/acsi.2020.5819

文献信息

• Synthesis, Crystal Structures and Catalytic Property of Dioxidomolybdenum(VI) Complexes with Tridentate Hydrazones
  作者：Xiao-Qiang Luo、Yong-Jun Han、Ling-Wei Xue

  DOI：10.17344/acsi.2020.5819

  日期：——

  New dioxidomolybdenum(VI) complexes with the formula [MoO 2 L(MeOH)], derived from N' -(5-chloro-2-hydroxybenzylidene)-2-methylbenzohydrazide (H 2 L 1 ) and N' -(3,5-dichloro-2-hydroxybenzylidene)-2-methylbenzohydrazide (H 2 L 2 ) were prepared. Crystal and molecular structures of the complexes were determined by single crystal X-ray diffraction method. Both complexes were further characterized by

  由N'-（5-氯-2-羟基苄叉基）-2-甲基苯并酰肼（H 2 L 1）和N'-（3,5）衍生的具有式[MoO 2 L（MeOH）]的新型二氧化钼（VI）配合物制备了-二氯-2-羟基亚苄基）-2-甲基苯并酰肼（H 2 L 2）。通过单晶X射线衍射法确定配合物的晶体和分子结构。两种配合物都通过元素分析和FT-IR光谱进一步表征。单晶X射线结构研究表明，L 1和L 2通过烯醇氧，酚氧和偶氮甲碱氮与MoO 2核配位。两个络合物中的Mo原子均为八面体配位。已经研究了使用PhIO和NaOCl作为氧化剂的配合物对苯乙烯环氧化的催化性能。
• Crystal structure and insulin-like activity of a vanadium complex derived from N′-(3,5-dichloro-2-hydroxybenzylidene)-2-methylbenzohydrazide
  作者：S. Han、Y. Wang

  DOI：10.1134/s002247661506027x

  日期：2015.11

  Vanadium complexes have been proved to possess an interesting insulin-like activity. The reaction of VO(acac)(2) with N'-(3,5-dichloro-2-hydroxybenzylidene)-2-methylbenzohydrazide (H2L) in methanol affords a new mononuclear vanadium (V) complex [VOL(OMe)(MeOH)]. The structure of the complex is characterized by physicochemical methods and single crystal X-ray diffraction. The complex crystallizes as the monoclinic space group P2(1)/n, with unit cell parameters a = 7.830(2) , b = 23.225(3) , c = 10.635(2) , beta = 101.947(2)A degrees, V = 1892.1(6) (3), Z = 4, R (1) = 0.0404, wR (2) = 0.0953, S = 1.037. The X-ray analysis indicates that the V atom in the complex is in the octahedral coordination. The insulin-like activity of the complex is studied.