1,1',1''-(benzene-1,3,5-triyl)tris(N,N-dimethylmethanamine) | 23539-76-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,1',1''-(benzene-1,3,5-triyl)tris(N,N-dimethylmethanamine)
• 英文别名: 1,3,5-tris(dimethylaminomethyl)benzene；1,3,5-tris-dimethylaminomethyl-benzene；1,3,5-Tris-dimethylaminomethyl-benzol；(3,5-bis-dimethylaminomethyl-benzyl)-dimethyl-amine；N-(3,5-Bis((dimethylamino)methyl)benzyl)-N,N-dimethylamine；1-[3,5-bis[(dimethylamino)methyl]phenyl]-N,N-dimethylmethanamine
• CAS: 23539-76-6
• 化学式: C₁₅H₂₇N₃
• 分子量: 249.399
• InChiKey: CQTGJMPFHKALGU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  9.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,1',1''-(benzene-1,3,5-triyl)tris(N,N-dimethylmethanamine) 、 碘甲烷 反应 13.0h， 生成 N,N',N''-<1,3,5-Benzoltriyltris(methylen)>tris(trimethylammonium)-triiodid
  参考文献：
  名称：

  Loehr, Hans-Gerd; Josel, Hans-Peter; Engel, Aloys, Chemische Berichte, 1984, vol. 117, # 4, p. 1487 - 1496

  摘要：

  DOI：
• 作为产物：
  描述：

  IrH₂{C₆H₂(CH₂N(CH₃)2)3}(C₈H₁₂) 以 二氯甲烷-D2 为溶剂， 生成 1,1',1''-(benzene-1,3,5-triyl)tris(N,N-dimethylmethanamine)
  参考文献：
  名称：

  由邻位螯合的芳基铱（I）化合物与二氢反应生成八面体铱（III）氢化物

  摘要：

  DOI：

  10.1021/om00097a018

文献信息

• Selective Synthesis of Bisdimethylamine Derivatives from Diols and an Aqueous Solution of Dimethylamine through Iridium‐Catalyzed Borrowing Hydrogen Pathway
  作者：Jaeyoung Jeong、Ken‐ichi Fujita

  DOI：10.1002/cctc.202101499

  日期：2022.2.8

  A new system for the selective synthesis of bisdimethylamine derivatives using diols and aqueous dimethylamine as the starting materials was developed. An iridium complex bearing an N-heterocyclic carbene ligand was used as the catalyst, and the reaction proceeded based on the borrowing hydrogen strategy in an aqueous medium under mild conditions. Various bisdimethylamine derivatives were obtained

  开发了一种以二醇和二甲胺水溶液为原料选择性合成二甲胺衍生物的新系统。以带有N-杂环卡宾配体的铱配合物为催化剂，反应在温和条件下在水介质中基于借氢策略进行。以良好至极好的收率获得了各种双二甲胺衍生物。
• Tridentate Lewis-acids based on triphenylsilane
  作者：Janek Tomaschautzky、Beate Neumann、Hans-Georg Stammler、Andreas Mix、Norbert W. Mitzel

  DOI：10.1039/c6dt04293g

  日期：——

  Several derivatives of the propeller-shaped ortho-substituted triphenylsilanes, carrying metal- or silicon-based acceptor groups, are reported. They were synthesized starting from tris(2-bromophenyl)fluorosilane, tris(2-vinylphenyl)fluorosilane and tris(2-ethynylphenyl)fluorosilane to generate a scope of Lewis-acidic molecules with different cavities. An improved synthetic protocol for donor-free

  报道了带有金属或硅基受体基团的螺旋桨状邻位取代的三苯基硅烷的几种衍生物。它们是从三（2-溴苯基）氟硅烷，三（2-乙烯基苯基）氟硅烷和三（2-乙炔基苯基）氟硅烷开始合成的，以产生一定范围的具有不同空穴的路易斯酸性分子。描述了一种用于无供体的三（2-锂基苯基）硅烷的改进的合成方案。首次提出了在客体-客体化学中尝试探测三倍烷烃官能化的邻位取代的三苯基硅烷与三齿Lewis碱性客体分子之间结合的方法。报道了双马来三茂铁的结晶状态下的合成和第一分子结构测定。
• Cobalt-Catalyzed Cyclotrimerization of Alkynes in Aqueous Solution
  作者：Matthew S. Sigman、Anson W. Fatland、Bruce E. Eaton

  DOI：10.1021/ja9807284

  日期：1998.5.1

  transition-metal-catalyzed cycloaddi-tion. Because aromatic rings are central to many biological,pharmaceutical, and polymer molecules, alkyne cyclotrimerizationis an important methodology. Vollhardt was first to realize thepotential of cobalt-catalyzed cyclotrimerization in organic syn-thesis.

  华盛顿州立大学化学系 P.O. Box 644630, Pullman, Washington 99164-4630NeXstar Pharmaceuticals, 2860 Wilderness PlaceBoulder, Colorado 80301 收到，1998 年 3 月 5 日许多用于组装环状有机分子的最有用的方法涉及过渡金属催化的环加成。由于芳环是许多生物、药物和聚合物分子的核心，因此炔烃环三聚是一种重要的方法。Vollhardt 是第一个意识到钴催化环三聚在有机合成中的潜力的人。
• NOVEL CASCADE POLYMER COMPLEXES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM
  申请人：SCHMITT-WILLICH Heribert

  公开号：US20080213187A1

  公开（公告）日：2008-09-04

  The invention relates to novel cascade polymer complexes, to compositions comprising these compounds, to the use of the complexes in NMR diagnosis, and to processes for preparing these compounds and compositions. The complex-forming cascade polymer complexes according to the invention can be described by general formula I: R-L-A-X—[Y-(Z-W—K w } z ) y ] x } a−1 (I) where R=is an HSA-binding unit, L=is a linker or a bond, A=is a nitrogen-containing cascade core of base multiplicity a, X and Y are independently of one another a direct linkage or a cascade reproduction unit of reproduction multiplicity x and y, respectively, Z and W=are independently of one another a direct linkage or a cascade reproduction unit of reproduction multiplicity z and w, respectively, K is the residue of a complexing agent, a=is numbers 2 to 12, and x, y, z and w are independently of one another the numbers 1 to 4, with the proviso that exactly one multiplicity of the base multiplicity a of the cascade core A represents exactly one point of linkage to L, and with the proviso that the cascade polymer complexes comprise in the complexing agent residue K in total at least 4 ions of an element of atomic number 20 to 29, 39, 42 to 44 or 57 to 83 and comprise where appropriate cations of inorganic and/or organic bases, amino acids or amino amides.

  该发明涉及新型级联聚合物复合物，包括这些化合物的组成，以及在核磁共振诊断中使用这些复合物的方法，以及制备这些化合物和组成物的过程。根据该发明，级联聚合物复合物可以用通用公式I描述：R-L-A-X—[Y-(Z-W—Kw}z)y]x}a−1(I)，其中R=HSA结合单元，L=连接物或键，A=含氮级联核心，基数为a，X和Y分别是直接连接或再生单位，再生次数分别为x和y，Z和W分别是直接连接或再生单位，再生次数分别为z和w，K是络合剂残基，a为2至12之间的数字，x、y、z和w分别是1到4之间的数字，但级联核心A的基数a的一个复数恰好表示与L的连接点，级联聚合物复合物包含在络合剂残基K中总共至少4个原子序数为20至29、39、42至44或57至83的元素离子，并包括必要时的无机和/或有机碱、氨基酸或氨基酰基的阳离子。
• [EN] SWITCHABLE HYDROPHILICITY SOLVENTS AND METHODS OF USE THEREOF<br/>[FR] SOLVANTS COMMUTABLES ET LEURS PROCÉDÉS D'UTILISATION
  申请人：UNIV KINGSTON

  公开号：WO2011050469A1

  公开（公告）日：2011-05-05

  A solvent that reversibly converts from a hydrophobic liquid form to hydrophilic liquid form upon contact with water and a selected trigger, e.g., contact with CO2, is described. The hydrophilic liquid form is readily converted back to the hydrophobic liquid form and water. The hydrophobic liquid is an amidine or amine. The hydrophilic liquid form comprises an amidinium salt or an ammonium salt.

  描述了一种溶剂，当与水和选择的触发器（例如与CO2接触）接触时，可从疏水液态形式可逆地转变为亲水液态形式。亲水液态形式很容易转变回疏水液态形式和水。疏水液态是一种酰胺或胺。亲水液态形式包括酰胺盐或铵盐。