N(2'-pyrrolidino-ethyl)-α,α-diphenyl acetamide hydrochloride

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N(2'-pyrrolidino-ethyl)-α,α-diphenyl acetamide hydrochloride
• 英文别名: 2,2-diphenyl-N-(2-pyrrolidin-1-ium-1-ylethyl)acetamide;chloride
• 化学式: C₂₀H₂₄N₂O*ClH
• 分子量: 344.884
• InChiKey: DURRPOQFSGOCHC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.45
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-(2-氨乙基)吡咯烷 、 二苯基乙酰氯 以 乙腈 为溶剂， 反应 6.0h， 以70%的产率得到N(2'-pyrrolidino-ethyl)-α,α-diphenyl acetamide hydrochloride
  参考文献：
  名称：

  Amide derivatives with H1-antihistaminic effect

  摘要：

  The synthesis and the structure-activity correlation of a series of N-aminoalkylacetamides as H1-antihistaminic agents have been carried out. The compounds were tested in vitro by measurement of the inhibition of histamine-induced contractions on isolated guinea pig ileum; the results are expressed as pA2.

  DOI：

  10.1016/s0031-6865(97)00025-3

文献信息

• US4122199A
  申请人：——

  公开号：US4122199A

  公开（公告）日：1978-10-24
• Amide derivatives with H1-antihistaminic effect
  作者：Carmela Saturnino、Paola Saturnino、Giovanni De Martino、Jean Charles Lancelot、Daniel Perrine、Ronon Boureau、Max Robba

  DOI：10.1016/s0031-6865(97)00025-3

  日期：1998.1

  The synthesis and the structure-activity correlation of a series of N-aminoalkylacetamides as H1-antihistaminic agents have been carried out. The compounds were tested in vitro by measurement of the inhibition of histamine-induced contractions on isolated guinea pig ileum; the results are expressed as pA2.