Bis-<2-methyl-5-nitro-phenyl>-disulfid | 92149-64-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Bis-<2-methyl-5-nitro-phenyl>-disulfid
• 英文别名: Bis-<5-nitro-o-tolyl>-disulfid；bis-(2-methyl-5-nitro-phenyl)-disulfide；Bis-(2-methyl-5-nitro-phenyl)-disulfid；1-Methyl-2-[(2-methyl-5-nitrophenyl)disulfanyl]-4-nitrobenzene；1-methyl-2-[(2-methyl-5-nitrophenyl)disulfanyl]-4-nitrobenzene
• CAS: 92149-64-9
• 化学式: C₁₄H₁₂N₂O₄S₂
• 分子量: 336.392
• InChiKey: SDUCOUOLSQFXKO-UHFFFAOYSA-N

物化性质

• 熔点：
  147.3-148 °C
• 沸点：
  469.1±45.0 °C(Predicted)
• 密度：
  1.44±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  142
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  Bis-<2-methyl-5-nitro-phenyl>-disulfid 在 氢氧化钾 作用下， 生成 2-甲基-5-硝基苯硫酚
  参考文献：
  名称：

  Notes - Synthetic Schistosomicides. I. A Diphenylsulfide Analog of Miracil D

  摘要：

  DOI：

  10.1021/jo01118a613
• 作为产物：
  描述：

  2-甲基-5-硝基苯磺酰氯 在 三溴化磷 作用下， 生成 Bis-<2-methyl-5-nitro-phenyl>-disulfid
  参考文献：
  名称：

  Management of the Guarani Aquifer System

  摘要：

  With an extension of 1.2 million square kilometers, the Guarani Aquifer System is one of the largest transboundary groundwater systems in the world. It underlies parts of Argentina, Brazil, Paraguay, and Uruguay and was only relatively recently recognized as a transboundary resource. The four countries are now in the process of starting up a project to elaborate and implement a common institutional and technical framework for managing and preserving the Guarani Aquifer System for current and future generations. This paper briefly presents the Guarani Aquifer System Project. The preparation process is described due to its particular interest for other similar multi-country endeavors. Following the presentation of the project, the paper takes a forward-looking approach and analyzes the applicability of current international law for transboundary groundwater resources in the context Of the Guarani Aquifer System. It concludes that while the basic principles espoused by international law relating to transboundary groundwater resources management are valid, they do not provide very specific guidance. The Guarani Aquifer System is unique and its complex features make it an eclectic case, which already is obliging all stakeholders to work out innovative measures - in the legal, institutional, technical, scientific, social, and economic realms - to develop appropriate activities for its sustainable management.

  DOI：

  10.1080/02508060308691684

文献信息

• Thermolyse von O,O-dialkyl-S-aryl-thiophosphorsäureestern
  作者：K. Pilgram、F. Korte

  DOI：10.1016/s0040-4020(01)98339-5

  日期：1965.1

  O,O-Dialkyl-S-aryl-phosphorothioates are thermally unstable and decompose readily at a temperature of about 150° with formation of alkyl aryl sulfides and polymeric alkyl meta- or -polyphosphates. Differences in reactivity within a series of 33 phosphorothioates are rationalized on the basis of steric and electromeric effects. The mechanism of the thermal degradation is discussed, the influence of

  O，O-二烷基-S-芳基-硫代磷酸酯是热不稳定的，并且在约150°的温度下容易分解，形成烷基芳基硫化物和聚合的烷基间-或-聚磷酸盐。在一系列33种硫代磷酸酯中，反应性的差异是根据空间效应和电子效应来合理化的。讨论了热降解的机理，研究了硫醚和苯酚对热分解速率的影响。
• [EN] SUBSTITUTED TRIAZINE PHENYLUREA DERIVATIVE AND USE THEREOF AGAINST TUMORS<br/>[FR] DÉRIVÉ SUBSTITUÉ DE TRIAZINE PHÉNYLURÉE ET SON UTILISATION CONTRE DES TUMEURS
  申请人：ZHEJIANG HISUN PHARM CO LTD

  公开号：WO2012159557A1

  公开（公告）日：2012-11-29

  一种如式I的取代的三嗪苯脲衍生物，及其作为蛋白激酶特别是Raf-1抑制剂的应用。该化合物可以用于治疗各种紊乱和疾病，特别是与蛋白激酶相关的疾病，例如癌症、心肌梗塞、脑血栓、贫血和丙型肝炎（HCV）等。
• Morgenstern,J.; Mayer,R., Zeitschrift fur Chemie, 1969, vol. 9, p. 182 - 183
  作者：Morgenstern,J.、Mayer,R.

  DOI：——

  日期：——
• Reaction of Cyclic Phosphoramidites with Disulfides. I. A Novel Synthesis of Phosphoramidothioates
  作者：Kurt Pilgram、Donald D. Phillips、Friedhelm Korte

  DOI：10.1021/jo01030a042

  日期：1964.7
• Management of the Guarani Aquifer System
  作者：Karin E. Kemper、Eduardo Mestre、Luiz Amore

  DOI：10.1080/02508060308691684

  日期：2003.6

  With an extension of 1.2 million square kilometers, the Guarani Aquifer System is one of the largest transboundary groundwater systems in the world. It underlies parts of Argentina, Brazil, Paraguay, and Uruguay and was only relatively recently recognized as a transboundary resource. The four countries are now in the process of starting up a project to elaborate and implement a common institutional and technical framework for managing and preserving the Guarani Aquifer System for current and future generations. This paper briefly presents the Guarani Aquifer System Project. The preparation process is described due to its particular interest for other similar multi-country endeavors. Following the presentation of the project, the paper takes a forward-looking approach and analyzes the applicability of current international law for transboundary groundwater resources in the context Of the Guarani Aquifer System. It concludes that while the basic principles espoused by international law relating to transboundary groundwater resources management are valid, they do not provide very specific guidance. The Guarani Aquifer System is unique and its complex features make it an eclectic case, which already is obliging all stakeholders to work out innovative measures - in the legal, institutional, technical, scientific, social, and economic realms - to develop appropriate activities for its sustainable management.