2-氟-5-甲基-3-吡啶胺 | 173435-33-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2-氟-5-甲基-3-吡啶胺
• 英文名称: 2-Fluoro-5-methylpyridin-3-amine
• CAS: 173435-33-1
• 化学式: C₆H₇FN₂
• mdl: MFCD13185334
• 分子量: 126.13
• InChiKey: ALBXVKCSHDJFNY-UHFFFAOYSA-N

物化性质

• 沸点：
  259.0±35.0 °C(Predicted)
• 密度：
  1.196±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.166
• 拓扑面积：
  38.9
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] DIHYDROOROTATE DEHYDROGENASE INHIBITORS<br/>[FR] INHIBITEURS DE DIHYDROOROTATE DÉSHYDROGÉNASE
  申请人：JANSSEN BIOTECH INC

  公开号：WO2020144638A1

  公开（公告）日：2020-07-16

  Disclosed are compounds, compositions and methods for treating diseases, disorders, or medical conditions that are affected by the modulation of DHODH. Such compounds are represented by Formula (I) as follows: wherein R1a, R1b, R2, and R3, are defined herein.

  揭示了一种通过调节DHODH来治疗受影响的疾病、疾病或医疗状况的化合物、组合物和方法。这些化合物由以下式（I）表示：其中R1a、R1b、R2和R3在此处定义。
• [EN] PHARMACEUTICAL COMPOUNDS<br/>[FR] COMPOSÉS PHARMACEUTIQUES
  申请人：REVIRAL LTD

  公开号：WO2021032992A1

  公开（公告）日：2021-02-25

  Benzodiazepine derivatives of formula (I): (I) wherein: each of R1 and R2 is independently H or halo; either (i) T is N, Z is C, ---a--- and --­c--- are bonds, and ---b--- and ---d--- are absent; or (ii) T is C, Z is N, ---b--- and ---d--- are bonds, and ---a--- and ---c--- are absent; each of R3 and R4 is independently halo, -OR6, -NR6R7, -COR8, -C(O)OR8, -CON(R8)2 or -R6; R5 is H or halo; each of R6 and R7 is independently H or a group selected from C1-C6 alkyl, C3-C10 cycloalkyl, C6-C10 aryl, 4- to 10-membered heterocyclyl and 4- to 10-membered heteroaryl, the group being unsubstituted or substituted; R8 is H or C1-C6 alkyl, each R8 being the same or different when two are present; n is 0 or 1; and one of V, W, X and Y is N or CH and the other three are CH; and the pharmaceutically acceptable salts thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection.

  公式（I）的苯二氮卓类衍生物：（I）其中：R1和R2中的每一个独立地是H或卤素；要么（i）T是N，Z是C，---a---和--c---是键，---b---和---d---是不存在的；要么（ii）T是C，Z是N，---b---和---d---是键，---a---和---c---是不存在的；R3和R4中的每一个独立地是卤素，-OR6，-NR6R7，-COR8，-C（O）OR8，-CON（R8）2或-R6；R5是H或卤素；R6和R7中的每一个独立地是H或从C1-C6烷基，C3-C10环烷基，C6-C10芳基，4-至10成员杂环烷基和4-至10成员杂芳基中选择的基团，该基团未取代或取代；R8是H或C1-C6烷基，当两个存在时R8相同或不同；n为0或1；V、W、X和Y中的一个是N或CH，另外三个是CH；其药用可接受的盐为RSV的抑制剂，因此可用于治疗或预防RSV感染。
• [EN] PYRIDINE DERIVATIVES AS KIF18A INHIBITORS<br/>[FR] DÉRIVÉS DE PYRIDINE EN TANT QU'INHIBITEURS DE KIF18A
  申请人：AMGEN INC

  公开号：WO2021026100A1

  公开（公告）日：2021-02-11

  Amide compounds of formula (I): as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.

  化合物的酰胺类似物（公式（I））：如本文所定义，并其合成中间体，能够调节KIF18A蛋白，从而影响细胞周期和细胞增殖的过程，以治疗癌症和癌症相关疾病。该发明还包括包括这些化合物的药物组合物，以及治疗与KIF18A活性相关的疾病状态的方法。
• 2-Benzylthio-8-amino(1,2,4)triazolo(1,5-pyridines
  申请人：Dow AgroSciences LLC

  公开号：EP0972774A2

  公开（公告）日：2000-01-19

  The invention relates to 2-benzylthio-8-amino[1,2,4]triazolo[1,5-a]pyridines and a process for the preparation thereof. These compounds can be used for the preparation of 2-benzylthio[1,2,4]triazolo[1,5-a]pyridine compounds, which are important intermediates in the preparation of N-aryl[1,2,4]triazolo[1,5-a]pyridines. The reaction is generally carried out by combining one molar equivalent of a 2-benzylthio-8-chloro[1,2,4]triazolo[1,5-a]pyridine compound with at least 3 molar equivalents of stannous chloride, one molar equivalent of stannic chloride, and an excess of hydrogen chloride or at least one molar equivalent of the alcohol.

  本发明涉及 2-苄硫基-8-氨基[1,2,4]三唑并[1,5-a]吡啶及其制备工艺。这些化合物可用于制备 2-苄硫基[1,2,4]三唑并[1,5-a]吡啶化合物，后者是制备 N-芳基[1,2,4]三唑并[1,5-a]吡啶的重要中间体。 该反应一般通过将 1 摩尔当量的 2-苄硫基-8-氯[1,2,4]三唑并[1,5-a]吡啶化合物与至少 3 摩尔当量的氯化亚锡、1 摩尔当量的氯化锡和过量的氯化氢或至少 1 摩尔当量的醇结合进行。
• N-PYRIDINYL 1,2,4]TRIAZOLO 1,5-C]PYRIMIDINE-2-SULFONAMIDE HERBICIDES
  申请人：DOWELANCO

  公开号：EP0717745A1

  公开（公告）日：1996-06-26