4,6-Dimethylpicolinimidamide hydrochloride | 112736-13-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4,6-Dimethylpicolinimidamide hydrochloride
• 英文别名: 4,6-dimethylpyridine-2-carboximidamide;hydrochloride
• CAS: 112736-13-7
• 化学式: C8H12ClN3
• 分子量: 185.65
• InChiKey: XWXLCWQLAJLOQK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  62.8
• 氢给体数：
  3
• 氢受体数：
  2

文献信息

• 2-Heteroaryl-imidazotriazinones and their use in the treatment of inflammatory or immune diseases
  申请人：Alonso-Alija Cristina

  公开号：US20060293326A1

  公开（公告）日：2006-12-28

  The invention relates to 2-Heteroaryl-imidazotriazinones, processes for their preparation and their use in medicaments, esp. for the treatment and/or prophylaxis of inflammatory processes and/or immune diseases. The present invention relates to compounds of the general formula (I) in which R 1 denotes 5- to 10-membered heteroaryl, which is optionally substituted by identical or different residues selected from the group consisting of halogen, (C 1 -C 4 )-alkyl, trifluoromthyl, cyano, nitro und trifluoromethoxy, denotes 3- to 10-membered carbocyclyl or carbon-bonded, 4- to 10-membered heterocyclyl, whereby carbocyclyl and heterocyclyl are optionally substituted by identical or different residues selected from the group consisting of (C 1 -C 6 )-aldyl, (C 1 -C 6 )-aldoxy, hydroxy, halogen, trifluoromethyl and oxo, or denotes (C 2 -C 10 )-alkyl, which is optionally substituted by identical or different residues selected from the group the group consisting of (C 1 -C 6 )-alkoxy, hydroxy, halogen, 3- to 10-membered carbocyclyl and oxo.

  本发明涉及2-杂环芳基咪唑三嗪酮的制备方法及其在药物中的应用，特别是用于治疗和/或预防炎症过程和/或免疫性疾病。本发明涉及通式（I）的化合物，其中R1表示5-至10-成员杂环芳基，该杂环芳基可以被选自卤素，（C1-C4）-烷基，三氟甲基，氰基，硝基和三氟甲氧基的相同或不同残基取代，或表示3-至10-成员碳环烷基或碳键结合的4-至10-成员杂环烷基，其中碳环烷基和杂环烷基可以被选自（C1-C6）-醛基，（C1-C6）-醛氧基，羟基，卤素，三氟甲基和氧代物的相同或不同残基取代，或表示（C2-C10）-烷基，该烷基可以被选自（C1-C6）-氧烷基，羟基，卤素，3-至10-成员碳环烷基和氧代物的相同或不同残基取代。
• 2-HETEROARYL-IMIDAZOTRIAZINONES AND THEIR USE IN THE TREATMENT OF INFLAMMATORY OR IMMUNE DISEASES
  申请人：Bayer HealthCare AG

  公开号：EP1399439A1

  公开（公告）日：2004-03-24
• [EN] 2-HETEROARYL-IMIDAZOTRIAZINONES AND THEIR USE IN THE TREATMENT OF INFLAMMATORY OR IMMUNE DISEASES<br/>[FR] 2-HETEROARYL-IMIDAZOTRIAZINONES ET UTILISATION DANS LE TRAITEMENT DE MALADIES INFLAMMATOIRES OU IMMUNITAIRES
  申请人：BAYER AG

  公开号：WO2002098873A1

  公开（公告）日：2002-12-12

  The invention relates to 2-Heteroaryl-imidazotriazinones, processes for their preparation and their use in medicaments, esp. for the treatment and/or prophylaxis of inflammatory processes and/or immune diseases. The present invention relates to compounds of the general formula (I) in which R1 denotes 5- to 10- membered heteroaryl, which is optionally substituted by identical or different residues selected from the group consisting of halogen, (C¿1?-C4)-alkyl, trifluoromthyl, cyano, nitro und trifluoromethoxy, denotes 3-to 10-membered carbocyclyl or carbon-bonded, 4- to 10-membered heterocyclyl, whereby carbocyclyl and heterocyclyl are optionally substituted by identical or different residues selected from the group consisting of (C1-C6)-aldyl, (C1-C6)-aldoxy, hydroxy, halogen, trifluoromethyl and oxo, or denotes (C2-C10)-alkyl, which is optionally substituted by identical or different residues selected from the group the group consisting of (C1-C6)-alkoxy, hydroxy, halogen, 3-to 10-membered carbocyclyl and oxo.