4-(1-phenylpentyl)morpholine | 111097-39-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-(1-phenylpentyl)morpholine
• 英文别名: N-(1-phenyl-pentyl)-morpholine
• CAS: 111097-39-3
• 化学式: C₁₅H₂₃NO
• 分子量: 233.354
• InChiKey: HLCQPCJQNNIARA-UHFFFAOYSA-N

物化性质

• 沸点：
  120-121 °C(Press: 0.6 Torr)
• 密度：
  0.998±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  戊基苯 在 四溴化碳 、 (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate 作用下， 以 二氯甲烷 为溶剂， 生成 4-(1-phenylpentyl)morpholine
  参考文献：
  名称：

  Visible-light-mediated benzylic sp3 C–H bond functionalization to C–Br or C–N bond

  摘要：

  A visible-light-promoted functionalization of unactivated benzylic sp(3) C-H bonds was developed. Ethylbenzene derivatives were converted to the corresponding benzyl bromides or afforded benzylamine derivatives in a one-pot manner under visible light photoredox conditions. (C) 2016 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2016.04.036

文献信息

• Selective carbophilic addition of organolithiums to thioamides. A novel synthesis of unsymmetrical ketones and α-alkylated amines
  作者：Yoshinori Tominaga、Shinya Kohra、Akira Hosomi

  DOI：10.1016/s0040-4039(01)81034-0

  日期：1987.1

  Thioamides, readily available from aldehydes, sulfur and secondary amines, can be converted to unsymmetrical ketones by the carbophilic addition of organolithiums to the thiocarbonyl group. Reduction of the intermediates with lithium aluminum hydride gives α-alkylated or α-arylated amines.

  硫酰胺很容易从醛，硫和仲胺中获得，可以通过将有机锂的碳亲碳加成到硫代羰基上，将硫酰胺转化为不对称的酮。用氢化锂铝还原中间体得到α-烷基化或α-芳基化的胺。
• Katritzky, Alan R.; Yannakopoulou, Konstantina; Lue, Ping, Journal of the Chemical Society. Perkin transactions I, 1989, p. 225 - 233
  作者：Katritzky, Alan R.、Yannakopoulou, Konstantina、Lue, Ping、Rasala, Danuta、Urogdi, Laszlo

  DOI：——

  日期：——
• KATRITZKY, ALAN R.;YANNAKOPOULOU, KONSTANTINA;LUE, PING;RASALA, DANUTA;UR+, J. CHEM. SOC. PERKIN TRANS. PT 1,(1989) N, C. 225-233
  作者：KATRITZKY, ALAN R.、YANNAKOPOULOU, KONSTANTINA、LUE, PING、RASALA, DANUTA、UR+

  DOI：——

  日期：——
• TOMINAGA YOSHINORI; KOHRA SHINYA; HOSOMI AKIRA, TETRAHEDRON LETT., 28,(1987) N 14, 1529-1532
  作者：TOMINAGA YOSHINORI、 KOHRA SHINYA、 HOSOMI AKIRA

  DOI：——

  日期：——
• Visible-light-mediated benzylic sp3 C–H bond functionalization to C–Br or C–N bond
  作者：Tianyuan Hou、Ping Lu、Pixu Li

  DOI：10.1016/j.tetlet.2016.04.036

  日期：2016.5

  A visible-light-promoted functionalization of unactivated benzylic sp(3) C-H bonds was developed. Ethylbenzene derivatives were converted to the corresponding benzyl bromides or afforded benzylamine derivatives in a one-pot manner under visible light photoredox conditions. (C) 2016 Elsevier Ltd. All rights reserved.