3-Hydroxy-2-methyl-3-(2-phenylpropan-2-yl)isoindol-1-one | 1197385-33-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 3-Hydroxy-2-methyl-3-(2-phenylpropan-2-yl)isoindol-1-one
• 英文别名: 3-hydroxy-2-methyl-3-(2-phenylpropan-2-yl)isoindol-1-one
• CAS: 1197385-33-3
• 化学式: C₁₈H₁₉NO₂
• 分子量: 281.354
• InChiKey: GVZHRSLOPMEYSU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-甲基邻苯二甲酰亚胺 、 Potassium;2-methyl-2-phenylpropanoate 以 水 、 丙酮 为溶剂， 反应 3.5h， 以76%的产率得到3-Hydroxy-2-methyl-3-(2-phenylpropan-2-yl)isoindol-1-one
  参考文献：
  名称：

  Photodecarboxylative benzylations of phthalimides

  摘要：

  Photoadditions of phenylacetates to phthalimides give the corresponding benzylated hydroxyphthalimidines in moderate to high yields of 29-90%. With 2-phenylpropanoate, photoaddition affords a diastereoisomeric mixture in a de of 24% in favour of the like-diastereoisomer. L-3-Phenyl lactate and 2-oxo-3-phenylpropanoate both furnish the benzylated product through subsequent loss of formaldehyde and decarbonylation, respectively. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.08.115

文献信息

• Photodecarboxylative benzylations of phthalimides
  作者：Fadi Hatoum、Sonia Gallagher、Louise Baragwanath、Johann Lex、Michael Oelgemöller

  DOI：10.1016/j.tetlet.2009.08.115

  日期：2009.11

  Photoadditions of phenylacetates to phthalimides give the corresponding benzylated hydroxyphthalimidines in moderate to high yields of 29-90%. With 2-phenylpropanoate, photoaddition affords a diastereoisomeric mixture in a de of 24% in favour of the like-diastereoisomer. L-3-Phenyl lactate and 2-oxo-3-phenylpropanoate both furnish the benzylated product through subsequent loss of formaldehyde and decarbonylation, respectively. (C) 2009 Elsevier Ltd. All rights reserved.