N-cyclohexylmethyl-N'-phenyl-urea | 92373-98-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-cyclohexylmethyl-N'-phenyl-urea
• 英文别名: N-Cyclohexylmethyl-N'-phenyl-harnstoff；N-Hexahydrobenzyl-N'-phenyl-harnstoff；Cyclohexylmethylphenylharnstoff；N-(cyclohexylmethyl)-N'-phenylurea；1-(cyclohexylmethyl)-3-phenylurea
• CAS: 92373-98-3
• 化学式: C₁₄H₂₀N₂O
• 分子量: 232.326
• InChiKey: RNPNQEFRIDREDZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  苯甲醇 在 氨 、 thorium dioxide 、 镍 作用下， 生成 N-cyclohexylmethyl-N'-phenyl-urea
  参考文献：
  名称：

  死亡和征兆的牺牲：在塔纳托拉查“测量”死者

  摘要：

  本文认为牺牲与具身之间存在内在联系，并考虑了印度尼西亚萨丹托拉查传统太平间仪式的意义和象征意义。这些仪式表现出不同的存在方式，导致不同的死亡方式。关注它们生成的牺牲模式，我讨论了这些差异以及它们被认为“从身体中出现”的方式。

  DOI：

  10.1002/j.1834-4461.2000.tb02720.x

文献信息

• Hypoglycaemic agents
  作者：D F Hayman、V Petrow、O Stephenson

  DOI：10.1111/j.2042-7158.1964.tb07510.x

  日期：2011.4.12

  Various 3-substituted derivatives of 1-(p-vinylbenzenesulphonyl)urea, 1-[p-(2-chloroethyl)benzenesulphonyl]urea and 1-[p-(2-bromoethyl)benzenesulphonyl]urea are described. Several of the compounds possess noteworthy hypoglycaemic activity on oral administration in rabbits. In contrast, several related 5-substituted derivatives of 2-[p-(2-chloroethyl)benzenesulphonamido]-1,3,4-thiadiazoles and -1,3,4-oxadiazoles were virtually inactive.

  标题：摘要 描述了1-(对乙烯基苯磺酰基)脲、1-[对-(2-氯乙基)苯磺酰基]脲和1-[对-(2-溴乙基)苯磺酰基]脲的各种3-取代衍生物。其中几种化合物在兔子口服后表现出显著的降糖活性。相比之下，几种相关的2-[对-(2-氯乙基)苯磺酰胺基]-1,3,4-噻二唑和-1,3,4-噁二唑的5-取代衍生物几乎没有活性。
• An efficient two-step synthesis of mono-, di- and triureas from resin-bound amides
  作者：Adel Nefzi、Nhi A Ong、Richard A Houghten

  DOI：10.1016/s0040-4039(00)00845-5

  日期：2000.7

  An efficient method for the solid-phase synthesis of mono-, di- and triureas from resin-bound monoamines, diamines and triamines is described. The exhaustive reduction of solid support-bound amides generated the requisite amines, which, following treatment with isocyanates and cleavage, provided the corresponding ureas in high purity and good yields.

  描述了一种从树脂结合的单胺，二胺和三胺固相合成单，二和三脲的有效方法。固体载体结合的酰胺的彻底还原产生了必要的胺，这些胺在用异氰酸酯处理并裂解后，以高纯度和高收率提供了相应的脲。
• Biochemical and microbiological evaluation of <i>N</i>-aryl urea derivatives against mycobacteria and mycobacterial hydrolases
  作者：Abhishek Vartak、Christopher Goins、Vinicius Calado Nogueira de Moura、Celine M. Schreidah、Alexander D. Landgraf、Boren Lin、Jianyang Du、Mary Jackson、Donald R. Ronning、Steven J. Sucheck

  DOI：10.1039/c9md00122k

  日期：——

  k inact/K i value of 2.3 ± 0.3 and 5.5 ± 0.4 × 10-3 μM-1 min-1, respectively. The library was also evaluated for minimum inhibitory concentration (MIC) against two strains of Mtb, Mycobacterium smegmatis, and Mycobacterium abscessus. Compounds 4a and 4c were active against Mtb H37Rv mc26206 with MIC values of 3.12 and 1.5 μM, respectively. Closely related 4e showed similar activity against Mtb H37Rv

  制备了聚焦的24种N-芳基脲衍生物文库，并针对结核分枝杆菌（Mtb）Rv3802c和Mtb Ag85C的丝氨酸酯酶进行了评估。对文库成员的选择性和抑制方式进行了评估。发现呋喃基尿素衍生物6c是Rv3802c最有效的非共价抑制剂，K i值为5.2±0.7μM。另一方面，基于三唑的脲10a和10b不可逆地选择性地抑制Ag85C，其ak inact / K i值分别为2.3±0.3和5.5±0.4×10-3μM-1min-1。还评估了文库对两种Mtb菌株（耻垢分枝杆菌和脓肿分枝杆菌）的最低抑制浓度（MIC）。化合物4a和4c具有抗Mtb H37Rv mc26206的活性，MIC值分别为3.12和1.5μM。密切相关的4e对Mtb H37Rv mc26206具有相似的活性，但对Mtb H37Ra，耻垢分枝杆菌和脓肿分枝杆菌也具有活性。化合物4a，4c和4e均包含一个共同的1-（环己基甲基）-3-苯
• INHIBITORS OF EPOXIDE HYDROLASES FOR THE TREATMENT OF INFLAMMATION
  申请人：Hammock D. Bruce

  公开号：US20070117782A1

  公开（公告）日：2007-05-24

  The invention provides compounds that inhibit epoxide hydrolase in therapeutic applications for treating hypertension. A preferred class of compounds for practicing the invention have the structure shown by Formula 1 wherein Z is oxygen or sulfur, W is carbon phosphorous or sulfur, X and Y is each independently nitrogen, oxygen, or sulfur, and X can further be carbon, at least one of R 1 -R 4 is hydrogen, R 2 is hydrogen when X is nitrogen but is not present when X is sulfur or oxygen, R 4 is hydrogen when Y is nitrogen but is not present when Y is sulfur or oxygen, R 1 and R 3 is each independently C 1 -C 20 substituted or unsubstituted alkyl, cycloalkyl, aryl, acyl, or heterocyclic.

  本发明提供了一些化合物，用于治疗高血压的治疗应用中，抑制环氧水解酶。实施本发明的优选化合物类别具有由式1所示的结构，其中Z为氧或硫，W为碳、磷或硫，X和Y各自独立地为氮、氧或硫，而X还可以是碳，R1-R4中至少有一个是氢，当X为氮时，R2为氢，但当X为硫或氧时，R2不存在，当Y为氮时，R4为氢，但当Y为硫或氧时，R4不存在，而R1和R3各自独立地为C1-C20取代或未取代的烷基、环烷基、芳基、酰基或杂环基。
• Thiol on silica as a ‘catch and release’ support for isocyanates to afford ureas
  作者：Yuri Bolshan、Miroslaw J. Tomaszewski、Vijayaratnam Santhakumar

  DOI：10.1016/j.tetlet.2007.05.050

  日期：2007.7

  Silica-bound thiocarbamates were prepared by Curtius rearrangement of carboxylic acids in the presence of thiol on silica gel. The solid supported thiocarbamates were found to be stable isocyanate equivalents, which upon treatment with amines efficiently afforded di- and tri-substituted ureas. The urea products released from the catch and release support were, in the majority of cases, greater than 95% pure and required no further work. (c) 2007 Elsevier Ltd. All rights reserved.