3-ethylbenzo[g]quinoxalin-2(1H)-one | 1010705-84-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3-ethylbenzo[g]quinoxalin-2(1H)-one
• 英文别名: 3-ethyl-1H-benzo[g]quinoxalin-2-one
• CAS: 1010705-84-6
• 化学式: C₁₄H₁₂N₂O
• 分子量: 224.262
• InChiKey: ZIOXSFSNYAHBKM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  41.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-酮丁酸 、 2,3-二氨基萘 在 蔗糖 作用下， 以 水 为溶剂， 反应 72.0h， 以93%的产率得到3-ethylbenzo[g]quinoxalin-2(1H)-one
  参考文献：
  名称：

  Synthesis of potential chemotherapic quinoxalinone derivatives by biocatalysis or microwave-assisted Hinsberg reaction

  摘要：

  In recent years, great efforts have been dedicated to the design of compounds acting as selective inhibitors of the HIV-1 reverse transcriptase (RT). Due to the promissory results previously attained with some quinoxaline derivatives, we aimed to improve the specific standard Hinsberg synthetic pathway by means of biocatalysis or microwave (MW) irradiation. Both techniques rendered the products in very good yields. However, employing the microwave-assisted organic synthesis (MAOS), in the absence of solvent, the same reactions may be completed in minutes. Some of these quinoxalmone derivatives exhibited good inhibitor activity against some human tumoral cells and the lymphoma related to HIV-1. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.11.204

文献信息

• Synthesis of potential chemotherapic quinoxalinone derivatives by biocatalysis or microwave-assisted Hinsberg reaction
  作者：Javier Gris、Romina Glisoni、Lucas Fabian、Beatriz Fernández、Albertina G. Moglioni

  DOI：10.1016/j.tetlet.2007.11.204

  日期：2008.2

  In recent years, great efforts have been dedicated to the design of compounds acting as selective inhibitors of the HIV-1 reverse transcriptase (RT). Due to the promissory results previously attained with some quinoxaline derivatives, we aimed to improve the specific standard Hinsberg synthetic pathway by means of biocatalysis or microwave (MW) irradiation. Both techniques rendered the products in very good yields. However, employing the microwave-assisted organic synthesis (MAOS), in the absence of solvent, the same reactions may be completed in minutes. Some of these quinoxalmone derivatives exhibited good inhibitor activity against some human tumoral cells and the lymphoma related to HIV-1. (c) 2007 Elsevier Ltd. All rights reserved.