3-(N,N-dimethylamino)-1-(dimethylphosphino)propane | 50518-38-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-(N,N-dimethylamino)-1-(dimethylphosphino)propane
• 英文别名: 3-dimethylphosphanyl-N,N-dimethylpropan-1-amine
• CAS: 50518-38-2
• 化学式: C₇H₁₈NP
• 分子量: 147.2
• InChiKey: SBHUNYHCPLYDGB-UHFFFAOYSA-N

物化性质

• 沸点：
  173.8±23.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-(N,N-dimethylamino)-1-(dimethylphosphino)propane 在 sulfur 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 以67%的产率得到[3-(Dimethyl-phosphinothioyl)-propyl]-dimethyl-amine
  参考文献：
  名称：

  Synthesis of bidentate mixed donor phosphorus/nitrogen ligands

  摘要：

  3-(N,N-Dimethylamino)-1-(dimethylphosphino)propane was synthesised by the photochemical addition of one equivalent of dimethylphosphine to N,N-dimethylallylamine. Synthesis of 2-(N,N-dimethylamino)dimethylphosphinoethane was achieved by the reaction of tetramethyldiphosphine with N,N-dimethyl-2-chloroethylamine.

  DOI：

  10.1016/s0040-4039(00)79978-3
• 作为产物：
  描述：

  二甲基磷化氢 、 二甲基烯丙基胺 在 偶氮二异丁腈 作用下， 以 乙醚 为溶剂， 反应 24.0h， 以97%的产率得到3-(N,N-dimethylamino)-1-(dimethylphosphino)propane
  参考文献：
  名称：

  Synthesis of bidentate mixed donor phosphorus/nitrogen ligands

  摘要：

  3-(N,N-Dimethylamino)-1-(dimethylphosphino)propane was synthesised by the photochemical addition of one equivalent of dimethylphosphine to N,N-dimethylallylamine. Synthesis of 2-(N,N-dimethylamino)dimethylphosphinoethane was achieved by the reaction of tetramethyldiphosphine with N,N-dimethyl-2-chloroethylamine.

  DOI：

  10.1016/s0040-4039(00)79978-3

文献信息

• NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF
  申请人：S&T Global Inc.

  公开号：EP3831841A1

  公开（公告）日：2021-06-09

  A compound of the Formula (I) is disclosed: or pharmaceutically acceptable salt thereof, wherein the symbols are as defined in the specification. Also described are a pharmaceutical composition comprising the same and a method for treating or preventing viral infections, inflammation, dry eye, central nervous disorders, cardiovascular diseases, cancer, obesity, diabetes, muscular dystrophy, lung, and liver, and kindey diseases, and hair loss using the same.

  公开了一种式 (I) 的化合物： 或其药学上可接受的盐，其中符号如说明书中所定义。还描述了包含该化合物的药物组合物，以及使用该化合物治疗或预防病毒感染、炎症、干眼症、中枢神经失调、心血管疾病、癌症、肥胖症、糖尿病、肌肉萎缩症、肺病、肝病、肾病和脱发的方法。
• Synthesis of bidentate mixed donor phosphorus/nitrogen ligands
  作者：Leslie D. Field、Ian J. Luck

  DOI：10.1016/s0040-4039(00)79978-3

  日期：1994.2

  3-(N,N-Dimethylamino)-1-(dimethylphosphino)propane was synthesised by the photochemical addition of one equivalent of dimethylphosphine to N,N-dimethylallylamine. Synthesis of 2-(N,N-dimethylamino)dimethylphosphinoethane was achieved by the reaction of tetramethyldiphosphine with N,N-dimethyl-2-chloroethylamine.