methyl chlorodiphenylacetate | 54311-64-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl chlorodiphenylacetate
• 英文别名: methyl α-chlorodiphenylacetate；Methyl 2-chloro-2,2-diphenylacetate
• CAS: 54311-64-7
• 化学式: C₁₅H₁₃ClO₂
• 分子量: 260.72
• InChiKey: ILVSUJHMWHCKOI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  methyl chlorodiphenylacetate 在 silver tetrafluoroborate 作用下， 以100%的产率得到二苯乙醇酸甲酯
  参考文献：
  名称：

  Reaction of diphenylmethyl cations in a strong acid. Participation of carbodications with positive charge substantially delocalized over the aromatic rings

  摘要：

  DOI：

  10.1021/ja00214a031
• 作为产物：
  描述：

  二苯基羟基乙酸 以 乙醚 、 二氯甲烷 为溶剂， 生成 methyl chlorodiphenylacetate
  参考文献：
  名称：

  Strazzolini, Paolo; Giumanini, Angelo G.; Verardo, Giancarlo, Recueil des Travaux Chimiques des Pays-Bas, 1991, vol. 110, # 1, p. 5 - 12

  摘要：

  DOI：

文献信息

• The reaction between acyl halides and alcohols: Alkyl halide vs. Ester formation
  作者：Paolo Strazzolini、Angelo G. Giumanini、Giancarlo Verardo

  DOI：10.1016/s0040-4020(01)80747-x

  日期：1994.4

  therefore, ester formation practically confined to a triggering role. But, in those cases where the cation is less easily formed, ester formation was favoured and, consequently, became the necessary elementary step towards alkyl halide formation. This final product, on the other hand, might be extremely slow to form in an SN2 reaction between the protonated ester function and the halide ion. In these hnstances

  在酰基卤和醇之间的反应中，热力学上有利的产物是游离羧酸和烷基卤。最初的反应通常是形成酯和HHal。当该醇非常容易被HHal质子化时产生烷基阳离子时，形成的H 2 O表现出超活性，并且与该醇成功竞争了酰基卤的制备，因此，酯的形成实际上局限于触发作用。但是，在那些阳离子不易形成的情况下，有利于酯的形成，因此成为形成卤代烷的必要的基本步骤。另一方面，最终产品在S N中的形成速度可能非常慢2质子化的酯官能团与卤离子之间的反应。因此，在这些情况下，以及在碱性溶剂竞争HHal质子的情况下，酯都是最终产物。α-羟基，α-苯基苯乙酸（2y）给出了上述虚线所示的一个显着例外，它似乎通过季中间体（E）进行了直接的氯-羟基交换，最后塌陷为α-氯- α-苯基苯乙酸（4y）。在严格相似的条件下，使用CH 2 Cl 2作为溶剂比较了不同的系统。测试了约28种不同的底物与AcCl（1a）的反应，而八种酰基卤（1）对（R
• Studies on antidiabetic agents. III. 5-Arylthiazolidine-2,4-diones as potent aldose reductase inhibitors.
  作者：TAKASHI SOHDA、KATSUTOSHI MIZUNO、EIKO IMAMIYA、HIROYUKI TAWADA、KANJI MEGURO、YUTAKA KAWAMATSU、YUJIRO YAMAMOTO

  DOI：10.1248/cpb.30.3601

  日期：——

  Thiazolidine-2, 4-dione derivatives having one or two substituent (s) such as phenyl, heteryl and alkyl group (s) at the 5-position were synthesized and evaluated as aldose reductase inhibitors. Inhibition by the active compounds of the swelling of the lens in a rat-lens-culture assay was also measured. Among these compounds, a series of 5-(3, 4-dialkoxyphenyl) thiazolidine-2, 4-diones showed pronounced activities in both assays. Structure-activity relationships are discussed and a new approach to the synthesis of 5-arylthiazolidine-2, 4-diones is described.

  具有一个或两个取代基（如苯基、杂基和烷基）的噻唑烷-2,4-二酮衍生物在5位合成并评估为醛糖还原酶抑制剂。在鼠晶状体培养检测中，活性化合物的抑制作用也被测量。在这些化合物中，一系列5-(3,4-二烷氧基苯基)噻唑烷-2,4-二酮在两种检测中显示出显著的活性。结构-活性关系进行了讨论，并描述了一种合成5-芳基噻唑烷-2,4-二酮的新方法。
• Phenyl-imidazolyl-fatty acid derivatives
  申请人：Bayer Aktiengesellschaft

  公开号：US03978069A1

  公开（公告）日：1976-08-31

  Phenyl-imidazolyl-fatty acid derivatives of the formula ##EQU1## wherein R.sup.1, R.sup.2, and R.sup.3 are the same or different, and are hydrogen or lower alkyl; R.sup.4 is hydrogen, alkyl, lower alkoxy, alkylmercapto, or an electro negative moiety; R.sup.5 is benzene, benzene substituted by alkyl, lower alkoxy, alkylmercapto or an electro negative moiety, or R.sup.5 is an aliphatic moiety; X is a carboxyl moiety or a grouping of a functional carboxylic acid derivative; m is 0, 1, 2, 3, 4, 5 or 6; and n is 0, 1 or 2, And pharmaceutically acceptable non-toxic salts thereof. These phenyl-imidazolyl-fatty acid derivatives exhibit antimycotic activity.

  Phenyl-imidazolyl-fatty acid derivatives的中文翻译为苯基-咪唑基脂肪酸衍生物，其化学式为##EQU1##其中R.sup.1、R.sup.2和R.sup.3相同或不同，可以是氢原子或较低的烷基；R.sup.4是氢原子、烷基、较低的烷氧基、烷基硫氧基或电负性基团；R.sup.5是苯环、被烷基、较低的烷氧基、烷基硫氧基或电负性基团取代的苯环，或R.sup.5是脂肪族基团；X是羧基或者是功能性羧酸衍生物的基团；m为0、1、2、3、4、5或6；n为0、1或2，以及其药学上可接受的无毒盐。这些苯基-咪唑基脂肪酸衍生物具有抗真菌活性。
• Synthesis of α-Chloroarylacetic Acid via Electrochemical Carboxylation of α,α-Dichloroarylmethane Derivatives
  作者：Corentin Maret、Nicolas David、David Pierrot、Eric Léonel、Vincent Levacher、Jean-François Brière、Sylvain Oudeyer

  DOI：10.3390/molecules28186704

  日期：——

  The electrocarboxylation of α,α-dichloroarylmethane derivatives in the presence of CO2 was achieved, providing several α-chloroarylacetic acid derivatives with modest yields but high selectivity (chlorinated vs. non-chlorinated or dicarboxylic acid products). The obtained products were then involved in several chemical transformations, underlining their potential as versatile intermediates in synthetic

  在 CO2 存在下实现了 α,α-二氯芳基甲烷衍生物的电羧化，提供了几种产率适中但选择性高的 α-氯芳基乙酸衍生物（氯化产物与非氯化产物或二羧酸产物）。获得的产品随后进行了多次化学转化，突显了它们作为合成化学中多功能中间体的潜力。基于控制实验和循环伏安法（CV）研究还提出了一种机制。
• Process for the preparation of copolymers of ethylene with at least one other 1-alkene
  申请人：STAMICARBON B.V.

  公开号：EP0044119A2

  公开（公告）日：1982-01-20

  Process for the preparation of copolymers consisting of 25-85% by wt. of ethylene, 15-75% by wt. of at least one other 1-alkene and optionally up to 20% by wt. of a polyunsaturated compound with application of a catalyst system containing a compound of a metal from sub-groups IV-VI of the periodic system and a compound of a metal from groups I-III of the periodic system, in which at least one hydrocarbon group is bound directly to the metal atom via a carbon atom, the polymerization being carried out in the presence of a halogen-containing compound of the general formula where A is a phenyl group which may contain one or two substituent halogen atoms or alkyl groups, or is a thienyl, furyl, pyrollyl, N-alkylpyrollyl or pyridyl group, which group is bound to the carbon atom directly or via a carbonyl group, X is a chlorine or bromine atom, Y is a chlorine, bromine or hydrogen atom or a hydrocarbon group with 1-8 carbon atoms, and Z is a nitrile group, a carboxyl group, an ester group, a hydrocarbyloxyalkylcarboxyl group, an carboxylic acid halide group, an amide group, a benzoyl group, a carboxyphenyl group or a carboxylhydrocarbylphenyl group.

  制备由 25-85%（重量百分比）乙烯、15-75%（重量百分比）至少一种其他 1-烯烃和（任选）最多 20%（重量百分比）多不饱和化合物组成的共聚物的工艺，其中催化剂体系含有周期系第Ⅳ-Ⅵ亚族金属化合物和周期系第Ⅰ-Ⅲ族金属化合物。聚合反应是在通式如下的含卤素化合物存在下进行的 其中 A 是苯基，可含有一个或两个取代卤素原子或烷基，或者是噻吩基、呋喃基、吡咯基、 N-烷基吡咯基或吡啶基，该基团直接或通过羰基与碳原子结合；X 是氯原子或溴原子；Y 是氯、Z 为腈基、羧基、酯基、烃基羧基、羧酸卤化基、酰胺基、苯甲酰基、羧基苯基或羧基氢羧基苯基。