2,6-dichloro-N-[(2,3-dihydro-1,4-benzodioxin-6-yl)methyl]benzamide | 1055212-30-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,6-dichloro-N-[(2,3-dihydro-1,4-benzodioxin-6-yl)methyl]benzamide
• 英文别名: 2,6-dichloro-N-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)benzamide
• CAS: 1055212-30-0
• 化学式: C₁₆H₁₃Cl₂NO₃
• 分子量: 338.19
• InChiKey: CVSBUTZQHXLXTB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,3-二氢-1,4-苯并二氧杂环-6-甲胺 、 2,6-二氯苯甲酰氯 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以92%的产率得到2,6-dichloro-N-[(2,3-dihydro-1,4-benzodioxin-6-yl)methyl]benzamide
  参考文献：
  名称：

  ALDH2 ACTIVATOR

  摘要：

  本发明提供了一种由下式（1）表示的化合物或其药学上可接受的盐，其中X和Y彼此相同或不同，表示氢原子、卤原子、C1-6烷基或C1-6甲氧基，其中C1-6甲氧基可以被C1-6烷氧基取代，Z和W彼此相同或不同，表示氢原子、卤原子或C1-6烷基。

  公开号：

  US20190231720A1

文献信息

• ALDH2 activator
  申请人：Eisai R&D Management Co., Ltd.

  公开号：US10406126B2

  公开（公告）日：2019-09-10

  The present invention provides a compound represented by formula (1): or pharmaceutically acceptable salt thereof, wherein X and Y are the same or different from each other and represent a hydrogen atom, a halogen atom, a C1-6 alkyl group, or a C1-6 alkoxy group, wherein the C1-6 alkoxy group may be substituted with a C1-6 alkoxy group, and Z and W are the same or different from each other and represent a hydrogen atom, a halogen atom, or a C1-6 alkyl group.

  本发明提供了一种由式（1）表示的化合物： 或其药学上可接受的盐，其中 X 和 Y 彼此相同或不同，代表氢原子、卤素原子、C1-6 烷基或 C1-6 烷氧基，其中 C1-6 烷氧基可被 C1-6 烷氧基取代，以及 Z 和 W 彼此相同或不同，代表氢原子、卤素原子或 C1-6 烷基。
• MITOCHONDRIAL ALDEHYDE DEHYDROGENASE-2 MODULATORS AND METHODS OF USE THEREOF
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：EP2126574B1

  公开（公告）日：2015-12-23
• Mitochondrial Aldehyde Dehydrogenase-2 Modulators and Methods of Use Thereof
  申请人：MOCHLY-ROSEN DARIA

  公开号：US20110105602A2

  公开（公告）日：2011-05-05

  The present invention provides compounds that function as modulators of mitochondrial aldehyde dehydrogenase-2 (ALDH2) activity; and pharmaceutical compositions comprising the compounds. The present invention provides therapeutic methods involving administering a subject compound, or a subject pharmaceutical composition. The present invention further provides assays for identifying agonists of ALDH2.
• MITOCHONDRIAL ALDEHYDE DEHYDROGENASE-2 MODULATORS FOR PROTECTING, EXPANDING AND INCREASING THE POTENCY OF HEMATOPOIETIC STEM CELLS
  申请人：The Borad of Trustees of the Leland Stanford Junior University

  公开号：US20190083457A1

  公开（公告）日：2019-03-21

  The present disclosure provides methods of protecting and expanding hematopoietic cells. The present disclosure also provides methods of increasing the potency of hematopoietic cells. Aspects of the methods include contacting a starting population of hematopoietic cells with a therapeutically effective amount of at least one ALDH2 agonist. Aspects include in vivo, in vitro and ex vivo methods of protecting, expanding and increasing the potency of hematopoietic cells. Aspects of the methods include treating an individual who is undergoing chemotherapy or radiation treatment for cancer, has been exposed to damaging toxins, has a genetic disease that leads to HSC damage, bone marrow failure, an autoimmune disease, or development of hematologic malignancies. Aspects of the methods also include treating a healthy individual who is a stem cell transplant donor.
• US9102651B2
  申请人：——

  公开号：US9102651B2

  公开（公告）日：2015-08-11