4'-ethyl 3-methyl 4-hydroxy-2,6-dimethylbiphenyl-3,4'-dicarboxylate | 1108169-29-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4'-ethyl 3-methyl 4-hydroxy-2,6-dimethylbiphenyl-3,4'-dicarboxylate
• 英文别名: Methyl 3-(4-ethoxycarbonylphenyl)-6-hydroxy-2,4-dimethylbenzoate
• CAS: 1108169-29-4
• 化学式: C₁₉H₂₀O₅
• 分子量: 328.365
• InChiKey: JQINYRRQWIABEH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  ethyl 4-(4-oxo-2-(trimethylsilyloxy)pent-2-en-3-yl)benzoate 、 1,3-bis(trimethylsiloxy)-1-methoxybuta-1,3-diene 在 四氯化钛 作用下， 以 二氯甲烷 为溶剂， 以60%的产率得到4'-ethyl 3-methyl 4-hydroxy-2,6-dimethylbiphenyl-3,4'-dicarboxylate
  参考文献：
  名称：

  Synthesis of sterically encumbered biaryls based on a ‘copper(I)-catalyzed arylation/[3+3] cyclocondensation’ strategy

  摘要：

  Sterically encumbered biaryls are prepared in two steps by Cul-proline-catalyzed arylation of acetylacetone to give 3-arylpentane-2,4-diones and subsequent formal [3+3] cyclization of the latter with 1,3-bis(trimethylsilyloxy)-1,3-dienes. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.10.093

文献信息

• Synthesis of sterically encumbered biaryls based on a ‘copper(I)-catalyzed arylation/[3+3] cyclocondensation’ strategy
  作者：Asad Ali、Ihsan Ullah、Muhammad Sher、Alexander Villinger、Peter Langer

  DOI：10.1016/j.tetlet.2008.10.093

  日期：2009.1

  Sterically encumbered biaryls are prepared in two steps by Cul-proline-catalyzed arylation of acetylacetone to give 3-arylpentane-2,4-diones and subsequent formal [3+3] cyclization of the latter with 1,3-bis(trimethylsilyloxy)-1,3-dienes. (C) 2008 Elsevier Ltd. All rights reserved.