benzoylamino-(4-hydroxy-phenyl)-acetic acid | 55399-86-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzoylamino-(4-hydroxy-phenyl)-acetic acid
• 英文别名: Benzoylamino-(4-hydroxy-phenyl)-essigsaeure；α-Benzamino-4-oxy-phenylessigsaeure；N-Benzoyl-p-hydroxyphenylglycin；(Benzoylamino)(4-hydroxyphenyl)acetic acid；2-benzamido-2-(4-hydroxyphenyl)acetic acid
• CAS: 55399-86-5
• 化学式: C₁₅H₁₃NO₄
• 分子量: 271.273
• InChiKey: AFBMJKAJPZXKPS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  86.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  对羟基苯甘氨酸 生成 benzoylamino-(4-hydroxy-phenyl)-acetic acid
  参考文献：
  名称：

  Aloy; Rabaut, Chemisches Zentralblatt, 1911, vol. 82, # II, p. 20

  摘要：

  DOI：

文献信息

• A new synthesis of n-acyl aromatic α-amino acids—amidoalkylation of aromatic and heterocyclic compounds with glyoxylic acid derivatives
  作者：D. Ben-Ishai、I. Sataty、Z. Bernstein

  DOI：10.1016/0040-4020(76)85215-5

  日期：1976.1

  The synthesis of N-acyl derivatives of aromatic α-amino acids 5 by the amidoalkylations of aromatic and heterocyclic compounds with glyoxylic acid amide adducts is described.

  描述了通过芳族和杂环化合物与乙醛酸酰胺加合物的酰胺烷基化来合成芳族α-氨基酸5的N-酰基衍生物。
• Pheny (alkyl)carboxylic acid derivatives and dionic phenylalkylheterocyclic derivatives and their use as medicines with serum glucose and/or serum lipid lowering activity
  申请人：Giannessi Fabio

  公开号：US20050032787A1

  公开（公告）日：2005-02-10

  Formula (I) compounds are described: Where the groups are as defined here below, and their use as medinies, particularly as serum glucose and serum lipid lowering agents. Said medicines are useful for the prophylaxis and treatment of diabetes, particularly type 2, and its complications, Syndrome X, the various forms of insulin resistance, and hyperlipidaemias, and present reduced side effects, and, particularly, reduced or no liver toxicity.

  描述了公式(I)化合物：其中各组如下所定义，并且它们的用途作为药物，特别是作为血清葡萄糖和血清脂质降低剂。所述药物对于预防和治疗糖尿病，特别是2型糖尿病及其并发症，综合征X，各种形式的胰岛素抵抗和高脂血症非常有用，并且具有减少的副作用，特别是减少或无肝毒性。
• PHENY(ALKYL)CARBOXYLIC ACID DERIVATIVES AND DIONIC PHENYLALKYLHETEROCYCLIC DERIVATIVES AND THEIR USE AS MEDICINES WITH SERUM GLUCOSE AND/OR SERUM LIPID LOWERING ACTIVITY
  申请人：SIGMA-TAU IndustrieFarmaceutiche Riunite S.p.A.

  公开号：EP1465858A2

  公开（公告）日：2004-10-13
• JPH06220002A
  申请人：——

  公开号：JPH06220002A

  公开（公告）日：1994-08-09
• [EN] PHENY(ALKYL)CARBOXYLIC ACID DERIVATIVES AND DIONIC PHENYLALKYLHETEROCYCLIC DERIVATIVES AND THEIR USE AS MEDICINES WITH SERUM GLUCOSE AND/OR SERUM LIPID LOWERING ACTIVITY<br/>[FR] DERIVES D'ACIDE PHENY(ALKYL)CARBOXYLIQUE ET DERIVES PHENYLALKYLHETEROCYCLIQUES DIONIQUES ET LEUR UTILISATION COMME MEDICAMENTS A ACTIVITE D'ABAISSEMENT DE NIVEAU DE GLUCOSE SERIQUE ET/OU LIPIDES SERIQUES
  申请人：SIGMA TAU IND FARMACEUTI

  公开号：WO2003059864A2

  公开（公告）日：2003-07-24

  Formula (I) compounds are described: Where the groups are as defined here below, and their use as medinies, particularly as serum glucose and serum lipid lowering agents. Said medicines are useful for the prophylaxis and treatment of diabetes, particularly type 2, and its complications, Syndrome X, the various forms of insulin resistance, and hyperlipidaemias, and present reduced side effects, and, particularly, reduced or no liver toxicity.