2-pyridinyl tetralone | 13640-50-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 2-pyridinyl tetralone
• 英文别名: 2-pyridin-2-ylmethylene-3,4-dihydro-2H-naphthalen-1-one；2-(α-Pyridylmethylen)-1-tetralon；2-(Pyridin-2-ylmethylidene)-3,4-dihydronaphthalen-1-one
• CAS: 13640-50-1
• 化学式: C₁₆H₁₃NO
• 分子量: 235.285
• InChiKey: ZXFHIHFMBOWHPB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  30
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-pyridinyl tetralone 在 ammonium acetate 、 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 甲醇 为溶剂， 反应 24.0h， 生成
  参考文献：
  名称：

  신규한 전자 수송 물질 및 이를 이용한 유기 발광 소자

  摘要：

  This invention relates to a novel electronic transport material and an organic light-emitting device including the same. By using the electronic transport material according to the present invention, it is possible to manufacture an organic light-emitting device with improved luminous characteristics and enhanced driving voltage, thereby inducing an increase in power efficiency and producing an organic light-emitting device with improved power consumption.

  公开号：

  KR101548686B1
• 作为产物：
  描述：

  吡啶-2-甲醛 、 3,4-二氢-1(2H)-萘酮 在 potassium hydroxide 作用下， 以 乙醇 为溶剂， 生成 2-pyridinyl tetralone
  参考文献：
  名称：

  UV-light induced domino type reactions: synthesis and photophysical properties of unreported nitrogen ring junction quinazolines

  摘要：

  已开发出一种利用紫外光合成5,6-二氢苯并[h][1,2,4]三唑[5,1-b]喹唑啉的方法。

  DOI：

  10.1039/c5ra00229j

文献信息

• Development of an Asymmetric Trimethylenemethane Cycloaddition Reaction: Application in the Enantioselective Synthesis of Highly Substituted Carbocycles
  作者：Barry M. Trost、Steven M. Silverman、James P. Stambuli

  DOI：10.1021/ja207550t

  日期：2011.12.7

  azetidine structures, is discussed. The conditions developed to effect an asymmetric TMM reaction using 2-trimethylsilylmethyl allyl acetate were shown to be tolerant of a wide variety of alkene acceptors, providing the desired methylenecyclopentanes with high levels of enantioselectivity. The donor scope was also explored, and substituted systems were tolerated, including one bearing a nitrile moiety. These

  已经开发了三亚甲基甲烷 (TMM) 与缺电子烯烃的对映选择性 [3+2] 环加成的协议。在这项工作中，新型亚磷酰胺配体的合成至关重要，并且详细介绍了这些配体的制备和反应性。讨论了配体设计的演变，从无环胺衍生的亚磷酰胺开始，并导致环状吡咯烷和氮杂环丁烷结构。为使用乙酸 2-三甲基甲硅烷基甲基烯丙酯进行不对称 TMM 反应而开发的条件被证明可以耐受多种烯烃受体，从而提供具有高水平对映选择性的所需亚甲基环戊烷。还探索了供体范围，并且可以容忍替代系统，包括带有腈部分的系统。
• Base-Catalyzed Traceless Silylation and Deoxygenative Cyclization of Chalcones to Cyclopropanes
  作者：Manas Kumar Sahu、Shubham Jaiswal、Sandip Pattanaik、Chidambaram Gunanathan

  DOI：10.1021/acs.joc.2c00374

  日期：2022.5.20

  synthetic methods from readily available compounds to complex products is of utmost interest in modern synthesis. Catalytic synthesis of cyclopropanes is important for diverse chemical applications. We present a method for the transformation of readily accessible α,β-unsaturated ketones (chalcones) to cyclopropanes. A simple base, KOH, catalyzed the selective reduction of the enone carbonyl functionality

  开发从容易获得的化合物到复杂产品的简单合成方法是现代合成的最大兴趣所在。环丙烷的催化合成对于各种化学应用很重要。我们提出了一种将容易获得的 α,β-不饱和酮（查耳酮）转化为环丙烷的方法。简单的碱 KOH 催化烯酮羰基官能团的选择性还原、脱氢甲硅烷基化和查耳酮的脱氧环化以提供环丙烷产物。具有扩展共轭和 4-色满酮底物的查耳酮也提供了相应的环丙烷。
• An Asymmetric Hydrogenation/N‐Alkylation Sequence for a Step‐Economical Route to Indolizidines and Quinolizidines
  作者：Wei Zhao、Wenji Wang、Huan Zhou、Qishan Liu、Zhiqing Ma、Haizhou Huang、Mingxin Chang

  DOI：10.1002/anie.202308836

  日期：2023.10.9

  Asymmetric hydrogenation of pyridines and subsequent N-alkylation lead to indolizidines and quinolizidines. The presence of Cl− results in retention of the absolute configuration of the initially formed alcohol. Noncovalent interactions, H-bonding, π-π stacking and electrostatic interactions also play important roles in regulating the stereoselectivity of the reaction process.

  吡啶的不对称氢化和随后的 N-烷基化产生吲哚里西啶和喹里西啶。Cl -的存在导致最初形成的醇的绝对构型得以保留。非共价相互作用、氢键、π-π堆积和静电相互作用在调节反应过程的立体选择性方面也发挥着重要作用。
• Synthesis, Topoisomerase I and II Inhibitory Activity, Cytotoxicity, and Structure-activity Relationship Study of Rigid Analogues of 2,4,6-Trisubstituted Pyridine Containing 5,6-Dihydrobenzo[h]quinoline Moiety
  作者：Byeong-Seon Jeong、Ho-Young Choi、Pritam Thapa、Radha Karki、Eun-Young Lee、Jung-Min Nam、Young-Hwa Na、Eun-Mi Ha、Young-Joo Kwon、Eung-Seok Lee

  DOI：10.5012/bkcs.2011.32.1.303

  日期：2011.1.20