4-Methyl-cyclohexyl-methylsulfid | 63231-70-9

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 4-Methyl-cyclohexyl-methylsulfid
• 英文别名: 1-Methyl-4-(methylthio)cyclohexane；1-methyl-4-methylsulfanylcyclohexane
• CAS: 63231-70-9
• 化学式: C₈H₁₆S
• 分子量: 144.281
• InChiKey: VWRBOIMILCEMGV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-Methyl-cyclohexyl-methylsulfid 生成 [dimethyl-(4-methylcyclohexyl)-λ4-sulfanyl] 4-methylbenzenesulfonate
  参考文献：
  名称：

  RUANO, J. L. G.;RODRIGUEZ, J.;ALCUDIA, F.;LLERA, J. M.;OLEFIROWICZ, E. M.+, J. ORG. CHEM., 52,(1987) N 18, 4099-4107

  摘要：

  DOI：
• 作为产物：
  描述：

  4-methylcyclohexyl p-toluenesulfonate 、 sodium thiomethoxide 生成 4-Methyl-cyclohexyl-methylsulfid
  参考文献：
  名称：

  RUANO, J. L. G.;RODRIGUEZ, J.;ALCUDIA, F.;LLERA, J. M.;OLEFIROWICZ, E. M.+, J. ORG. CHEM., 52,(1987) N 18, 4099-4107

  摘要：

  DOI：

文献信息

• FUNGICIDAL COMPOSITIONS
  申请人：Haas Ulrich Johannes

  公开号：US20140335201A1

  公开（公告）日：2014-11-13

  The present invention provides a composition comprising a combination of components A) and B), wherein component A) is a compound of formula (I) and the component (B) is a further fungicide, insecticide or herbicide.

  本发明提供了一种组合物，包括组分A)和B)，其中组分A)是化合物的公式(I)，组分B)是另一种杀真菌剂、杀虫剂或除草剂。
• [EN] BENZOXAZINE MONOMERS AND POLYMERIC COATINGS<br/>[FR] MONOMÈRES DE BENZOXAZINE ET REVÊTEMENTS POLYMÈRES
  申请人：LUXEMBOURG INST SCIENCE & TECH LIST

  公开号：WO2020193293A1

  公开（公告）日：2020-10-01

  The invention is directed to monomer(s) based on a 3,4-dihydro-2H-1,3-benzoxazine derivative. The invention also concerns a composition comprising a mixture of said monomer(s) and of a second benzoxazine derivative selected from the group consisting of monofunctional amines bridged with diphenolic compounds, monophenolic compounds bridged with diamines and diamines bridged by diphenolic compounds, or a mixture thereof. These compounds are suited for the preparation of benzoxazine derivative heterogeneous polymers, for example having the shape of coatings or films, exhibiting enhanced anti-inflammatory and/or anti-oxidant properties. A material with a coated substrate with said heterogeneous polymer may be a part of implantable materials, such as implantable metallic apparatus such as a catheter, a metallic implant, or a metallic prosthesis, biologically compatible. These implantable materials may be safely used because they are preventing any inflammatory and/or oxidative reaction(s) from a host into which the coated substrate is grafted or implanted.

  该发明涉及基于3,4-二氢-2H-1,3-苯并噁嗪衍生物的单体。该发明还涉及包含所述单体和从单功能胺与二酚化合物桥接、单酚化合物与二胺桥接或二胺与二酚化合物桥接的第二苯并噁嗪衍生物的混合物的组合物。这些化合物适用于制备苯并噁嗪衍生物杂聚物，例如形成涂层或薄膜的材料，具有增强的抗炎和/或抗氧化性能。涂有所述杂聚物的基材的材料可能是植入材料的一部分，例如植入金属器械如导管、金属植入物或金属假体，具有生物相容性。这些植入材料可以安全使用，因为它们可以防止任何宿主体内涂有基材的炎症和/或氧化反应。
• [EN] NOVEL SEMI-SYNTHETIC GLYCOPEPTIDES AS ANTIBACTERIAL AGENTS<br/>[FR] NOUVEAUX GLYCOPEPTIDES SEMI-SYNTHÉTIQUES COMME AGENTS ANTIBACTÉRIENS
  申请人：LEAD THERAPEUTICS INC

  公开号：WO2010065174A1

  公开（公告）日：2010-06-10

  Semi-synthetic glycopeptides having antibacterial activity are described, in particular, the semi¬ synthetic glycopeptides described herein are made by chemical modification of a glycopeptide (Compound A, Compound B, Compound H or Compound C) or monosaccharide made by hydrolyzing the disaccharide moiety of the amino acid-4 of the parent glycopeptide in acidic medium to give the amino acid-4 monosaccharide; conversion of the monosaccharide to the amino-sugar derivative; acylation of the amino substituent on the amino acid-4 amino-substituted sugar moiety on these scaffolds with certain acyl groups; and conversion of the acid moiety on the macrocyclic ring of these scaffolds to certain substituted amides. Key reaction is the treatment of properly protected intermediate compound with isocyanate. Also provided are methods for the synthesis of the compounds, pharmaceutical compositions containing the compounds, and methods of use of the compounds for the treatment and/or prophylaxis of diseases, especially bacterial infections.

  本文介绍了具有抗菌活性的半合成糖肽，特别是在这里描述的半合成糖肽是通过化学修饰糖肽（化合物A、化合物B、化合物H或化合物C）或通过在酸性介质中水解母体糖肽的氨基酸-4的二糖基团，从而得到氨基酸-4单糖的方法制备的；将单糖转化为氨基糖衍生物；用特定的酰基基团对这些支架上氨基酸-4氨基取代糖基团上的氨基取代基进行酰化；并将这些支架上的大环环上的酸基团转化为某些取代酰胺。关键反应是用异氰酸酯处理适当保护的中间化合物。还提供了合成这些化合物的方法，含有这些化合物的制药组合物以及用于治疗和/或预防疾病，特别是细菌感染的化合物的使用方法。
• Methods and compositions of novel triazine compounds
  申请人：Timmer T. Richard

  公开号：US20070099874A1

  公开（公告）日：2007-05-03

  The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.

  本发明涉及用于治疗由炎症反应引起的病理生理状态的化合物的方法和组合物。特别地，本发明涉及抑制或阻断糖化蛋白诱导内皮细胞信号相关炎症反应的化合物。本发明涉及抑制平滑肌增殖的化合物。特别地，本发明涉及通过调节HSPG（如Perlecan）来抑制平滑肌细胞增殖的化合物。本发明进一步涉及使用化合物治疗由平滑肌增殖所特征的血管闭塞性疾病，例如再狭窄和动脉粥样硬化。
• Medical devices employing triazine compounds and compositions thereof
  申请人：Timmer T. Richard

  公开号：US20070122444A1

  公开（公告）日：2007-05-31

  The present invention relates to methods, compounds, and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses, and is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention also relates to compounds that inhibit smooth muscle proliferation, for example, by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis. This invention also relates to medical devices, such as a stent, comprising a compound or composition of this invention disposed on or within the medical device.

  本发明涉及用于治疗由炎症反应引起的病理生理条件的方法、化合物和组合物，其针对的是抑制或阻断糖基化蛋白诱导的内皮细胞信号相关炎症反应的化合物。本发明还涉及抑制平滑肌增殖的化合物，例如通过调节HSPGs（如Perlecan）来实现。本发明进一步涉及使用化合物来治疗由平滑肌增殖所特征的血管闭塞性疾病，例如再狭窄和动脉粥样硬化。本发明还涉及医疗器械，例如支架，其包括本发明的化合物或组合物在医疗器械上或内部安置。