2-氨基-6-乙基-4(1H)-蝶啶酮 | 25716-32-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 蝶啶及其衍生物
• 中文名称: 2-氨基-6-乙基-4(1H)-蝶啶酮
• 英文名称: 6-ethylpterin
• 英文别名: 2-Amino-6-ethylpteridin-4(1H)-one；2-amino-6-ethyl-3H-pteridin-4-one
• CAS: 25716-32-9
• 化学式: C₈H₉N₅O
• 分子量: 191.192
• InChiKey: BOLYAZAICFKNFX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  93.3
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  2-氨基-6-乙基-4(1H)-蝶啶酮 在 platinum(IV) oxide 氢气 作用下， 以 盐酸 、 乙醇 为溶剂， 20.0 ℃ 、95.99 kPa 条件下， 生成 6-ethyl-5,6,7,8-tetrahydropterin hydrochloride
  参考文献：
  名称：

  The dihydropteridine reductase (human brain) activity of some lipophilic quinonoid dihydropterins

  摘要：

  DOI：

  10.1016/0223-5234(87)90001-8
• 作为产物：
  描述：

  1-methylthio-1-butanol-2-one 、 2,4,5-triamino-6-hydroxypyrimidine sulfate 在 sodium hydrogensulfite 、 sodium sulfite 作用下， 以 水 为溶剂， 反应 120.0h， 生成 2-氨基-7-乙基-4(1H)-蝶啶酮 、 2-氨基-6-乙基-4(1H)-蝶啶酮
  参考文献：
  名称：

  The dihydropteridine reductase (human brain) activity of some lipophilic quinonoid dihydropterins

  摘要：

  DOI：

  10.1016/0223-5234(87)90001-8

文献信息

• AZIRIDINYL-EPOTHILONE COMPOUNDS
  申请人：Vite D. Gregory

  公开号：US20070276018A1

  公开（公告）日：2007-11-29

  The present invention is directed to aziridinyl epothilone compounds as further described herein, and/or pharmaceutically-acceptable salts and/or solvates thereof having the following Formula: wherein K is —O—, —S—, or —NR 7 —; A is —(CR 8 R 9 )—(CH 2 ) m -Z- wherein Z is —(CHR 10 )—, —C(═O)—, —C(═O)—C(═O)—, —OC(═O)—, —N(R 11 )C(═O)—, —SO 2 —, or —N(R 11 )SO 2 —; B 1 is hydroxyl or cyano and R 1 is hydrogen or B 1 and R 1 are taken together to form a double bond; R 2 , R 3 , and R 5 are, independently, hydrogen, alkyl, substituted alkyl, aryl or substituted aryl; or R 2 and R 3 may be taken together with the carbon to which they are attached to form an optionally substituted cycloalkyl; R 4 is hydrogen, alkyl, alkenyl, substituted alkyl, substituted alkenyl, aryl, or substituted aryl; R 6 is hydrogen, alkyl or substituted alkyl; R 7 , R 8 , R 9 , R 10 , R 11 and R 12 are independently hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heterocycloalkyl, substituted heterocycloalkyl, heteroaryl, or substituted heteroaryl; and R 13 is aryl, substituted aryl, heteroaryl or substituted heteroaryl.

  本发明涉及如下所述的吲哚环毒毒素化合物，以及/或其在下式中具有以下结构的药学上可接受的盐和/或溶剂：其中K为—O—、—S—或—NR7—；A为—(CR8R9)—(CH2)m-Z-，其中Z为—(CHR10)—、—C(═O)—、—C(═O)—C(═O)—、—OC(═O)—、—N(R11)C(═O)—、—SO2—或—N(R11)SO2—；B1为羟基或氰基，R1为氢或B1和R1一起形成双键；R2、R3和R5独立地为氢、烷基、取代烷基、芳基或取代芳基；或R2和R3可以与它们连接的碳一起形成可选择取代的环烷基；R4为氢、烷基、烯烃基、取代烷基、取代烯烃基、芳基或取代芳基；R6为氢、烷基或取代烷基；R7、R8、R9、R10、R11和R12独立地为氢、烷基、取代烷基、环烷基、取代环烷基、芳基、取代芳基、杂环烷基、取代杂环烷基、杂芳基或取代杂芳基；而R13为芳基、取代芳基、杂芳基或取代杂芳基。
• CONJUGATES OF AZIRIDINYL-EPOTHILONE ANALOGS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME
  申请人：Vite D. Gregory

  公开号：US20070275904A1

  公开（公告）日：2007-11-29

  The present invention is directed to conjugated compounds comprising a folate, or an analog or derivative thereof, and an aziridinyl epothilone analog, as further described herein, and/or pharmaceutically-acceptable salts and/or solvates thereof, useful in the treatment of cancer or other folate-receptor associated conditions.

  本发明涉及包含叶酸、叶酸类似物或衍生物以及环氧紫杉烷类似物的共轭化合物，如下文进一步描述，并/或其药用可接受盐和/或溶剂，用于治疗癌症或其他叶酸受体相关疾病。
• [EN] TOPOISOMERASE POISONS<br/>[FR] POISONS DE TOPOISOMÉRASE
  申请人：UNIV RUTGERS

  公开号：WO2017176648A1

  公开（公告）日：2017-10-12

  Provided herein are compounds of formula (I): and salts thereof. Also provided are pharmaceutical compositions comprising a compound of formula (I), processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula (I), and therapeutic methods for treating diseases such as cancer, a bacterial infection or a fungal infection using compounds of formula (I).

  本文提供的是式(I)的化合物及其盐。还提供了包括式(I)的化合物的药物组合物，制备式(I)的化合物的方法，制备式(I)的有用中间体，以及使用式(I)的化合物治疗疾病（如癌症、细菌感染或真菌感染）的治疗方法。
• CAMPTOTHECIN DERIVATIVES AS CHEMORADIOSENSITIZING AGENTS
  申请人：California Pacific Medical Center

  公开号：EP1951231B1

  公开（公告）日：2013-07-31
• SELECTIVE INHIBITION OF PHOSPHOENOLPYRUVATE CARBOXYLASES OF C4 PLANTS
  申请人：Heinrich Heine Universität Düsseldorf

  公开号：EP2797417B1

  公开（公告）日：2019-07-31