2-isobutyl-2-methyl-1,3-dithiolane | 6008-87-3

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫代缩醛
• 英文名称: 2-isobutyl-2-methyl-1,3-dithiolane
• 英文别名: Methyl-isobutyl-keton-aethylenthioketal；2-Methyl-2-(2-methylpropyl)-1,3-dithiolane；2-methyl-2-(2-methylpropyl)-1,3-dithiolane
• CAS: 6008-87-3
• 化学式: C₈H₁₆S₂
• 分子量: 176.347
• InChiKey: DPDRMMXURAAIBT-UHFFFAOYSA-N

物化性质

• 沸点：
  231.9±15.0 °C(Predicted)
• 密度：
  0.995±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  50.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-isobutyl-2-methyl-1,3-dithiolane 在 Clayan 作用下， 反应 0.05h， 以83%的产率得到4-甲基-2-戊酮
  参考文献：
  名称：

  Microwave Thermolysis Vi : A Rapid and General Method for Dethioacetalization Using “Clayan” in Dry Media

  摘要：

  A variety of thioacetals, dithiolanes and dithianes are deprotected into their carbonyl compounds using clay supported ammonium nitrate "Clayan" under microwave irradiation. The present method avoids the use of toxic oxidants and excess of solvent.

  DOI：

  10.1080/00397919908086080
• 作为产物：
  描述：

  1,2-乙二硫醇 、 4-甲基-2-戊酮 以90%的产率得到2-isobutyl-2-methyl-1,3-dithiolane
  参考文献：
  名称：

  1,3,4-Thiadiazol-2-ylphenyl-1,2,4,5-tetrazines: efficient synthesis via Pinner reaction and their luminescent properties

  摘要：

  DOI：

  10.24820/ark.5550190.p011.476

文献信息

• Highly Efficient Transthioacetalization of O,O-Acetals Catalyzed by Indium(III) Chloride
  作者：Brindaban C. Ranu、Arijit Das、Sampak Samanta

  DOI：10.1055/s-2002-25347

  日期：——

  A simple, efficient and general procedure has been developed for the transthioacetalization of O,O-acetals catalyzed by indium(III) chloride in 1,2-dichloroethane.

  已开发出一种简便、高效且通用的方法，用于在1,2-二氯乙烷中通过三氯化铟催化的O,O-缩醛的转硫缩醛化反应。
• Microwave Thermolysis Vi : A Rapid and General Method for Dethioacetalization Using “Clayan” in Dry Media
  作者：H. M. Meshram、Gondi Sudershan Reddy、G. Sumitra、J. S. Yadav

  DOI：10.1080/00397919908086080

  日期：1999.4

  A variety of thioacetals, dithiolanes and dithianes are deprotected into their carbonyl compounds using clay supported ammonium nitrate "Clayan" under microwave irradiation. The present method avoids the use of toxic oxidants and excess of solvent.
• Chemoselective Dithioacetalization and Oxathioacetalization of Carbonyl Compounds Using Alumina Sulfuric Acid as Catalyst
  作者：Hamid Reza Shaterian、Asghar Hosseinian、Majid Ghashang

  DOI：10.1080/00397910802272022

  日期：2008.11.3

  Carbonyl compounds have been successfully converted into their corresponding dithiolane, dithiane, and oxathiolane derivatives using a catalytic amount of alumina sulfuric acid (Al2O3-SO3H) with excellent yields at room temperature in short reaction times under mild conditions. This simple method is a highly chemoselective procedure for protection of aldehydes in the presence of ketones, and the heterogeneous catalyst can be recovered and reused several times without any loss of its activity.
• 1,3,4-Thiadiazol-2-ylphenyl-1,2,4,5-tetrazines: efficient synthesis via Pinner reaction and their luminescent properties
  作者：Anna Maj、Agnieszka Kudelko、Marcin Swiatkowski

  DOI：10.24820/ark.5550190.p011.476

  日期：——