2-Mercaptomethylphenol | 119354-00-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-Mercaptomethylphenol
• 英文别名: Thiosaligenin；2-(Sulfanylmethyl)phenol
• CAS: 119354-00-6
• 化学式: C₇H₈OS
• 分子量: 140.206
• InChiKey: VWSBAUGMCDGBIL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  21.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-Mercaptomethylphenol 在 lithium aluminium tetrahydride 、 对甲苯磺酸 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 生成 2-(3-Hydroxy-4-methoxyphenyl)-4H-1,3-benzoxathiine
  参考文献：
  名称：

  Arnoldi, Anna; Bassoli, Angela; Merlini, Lucio, Journal of the Chemical Society. Perkin transactions I, 1993, # 12, p. 1359 - 1366

  摘要：

  DOI：
• 作为产物：
  描述：

  2-(溴甲基)乙酸苯酯 在 sodium hydroxide 、 sodium hydrogensulfide 、 四丁基溴化铵 作用下， 生成 2-Mercaptomethylphenol
  参考文献：
  名称：

  Arnoldi, Anna; Bassoli, Angela; Merlini, Lucio, Journal of the Chemical Society. Perkin transactions I, 1993, # 12, p. 1359 - 1366

  摘要：

  DOI：

文献信息

• Selective arylthiolane deprotection by singlet oxygen: a promising tool for sensors and prodrugs
  作者：Brian M. Lamb、Carlos F. Barbas III

  DOI：10.1039/c4cc09040c

  日期：——

  A routine thioketal protecting group reacts rapidly and selectively with singlet oxygen to reveal ketone products in good (aryl 1,3-dithiolane) to excellent (aryl 1,3-oxathiolane) yields. Arylthiolanes are stable to biologically relevant reactive oxygen species and can be used as a light-activated gating mechanism for activating fluorescent sensors or small molecule prodrugs.

  一种常规的硫代烷基保护基与单线态氧迅速且选择性地反应，以揭示酮产物，产率从良好（芳基1,3-二硫杂环）到优秀（芳基1,3-氧硫杂环）。芳基硫代杂环对生物相关的活性氧物种稳定，并可用作激活荧光传感器或小分子前药的光激活门控机制。
• [EN] CHIRAL IMIDODIPHOSPHATES AND DERIVATIVES THEREOF<br/>[FR] IMIDODIPHOSPHATES CHIRAUX ET DÉRIVÉS ASSOCIÉS
  申请人：STUDIENGESELLSCHAFT KOHLE MBH

  公开号：WO2013104604A1

  公开（公告）日：2013-07-18

  The invention relates to chiral imidodiphosphates and derivatives thereof having the general formula I, The compounds are suitable as chiral Brønsted acid catalysts, phase-transfer catalysts, chiral anions for organic salts, metal salts or metal complexes for catalysis.

  该发明涉及具有一般式I的手性咪唑二磷酸酯及其衍生物。这些化合物适用作为手性Brønsted酸催化剂、相转移催化剂、有机盐、金属盐或金属络合物的手性阴离子，用于催化。
• Improved process for the preparation of mercaptomethylphenois
  申请人：——

  公开号：US20010020116A1

  公开（公告）日：2001-09-06

  There is disclosed an improved process for the preparation of a compound of the formula I 1 wherein n is 0 or 1, R 1 is C 1 -C 12 alkyl or —CH 2 SR 3 , R 2 is C 1 -C 12 alkyl, C 7 -C 9 phenylalkyl, C 7 -C 9 -phenylalkyl substituted on the phenyl radical by from 1 to 3 C 1 -C 4 alkyl groups; or —CH 2 SR 3 , R 3 is C 6 -C 18 alkyl, phenyl or benzyl, R 4 is hydrogen or methyl, R 5 is hydrogen or methyl, with the proviso that R 4 and R 5 are not simultaneously methyl, by reacting a compound of the formula II 2 wherein n, R 4 and R 5 are as previously defined, R 11 is hydrogen or C 1 -C 12 alkyl; and R 12 is hydrogen, C 1 -C 12 alkyl, C 7 -C 9 phenylalkyl, C 7 -C 9 phenylalkyl substituted on the phenyl radical by from 1 to 3 C 1 -C 4 alkyl groups; with formaldehyde or a compound that liberates formaldehyde under the reaction conditions and with at least one compound of the formula III R 3 SH (III) wherein R 3 is as previously defined, in the presence of a base, said base being mono or dimethylamine or mono or diethylamine, which process comprises treating afterwards the reaction product with a reducing agent.

  公开了一种改进的制备式I1化合物的方法，其中n为0或1，R1为C1-C12烷基或—CH2SR3，R2为C1-C12烷基，C7-C9苯基烷基，C7-C9苯基烷基在苯基上被1至3个C1-C4烷基取代；或—CH2SR3，R3为C6-C18烷基，苯基或苄基，R4为氢或甲基，R5为氢或甲基，但R4和R5不能同时为甲基，通过将式II2化合物与甲醛或在反应条件下释放甲醛的化合物以及至少一种式III R3SH (III)化合物在碱的存在下反应，所述碱为单甲基或二甲基胺或单乙基或二乙基胺，然后用还原剂处理反应产物。
• Thio-Salalen Catalyst
  申请人：ExxonMobil Chemical Patents Inc.

  公开号：US20140378634A1

  公开（公告）日：2014-12-25

  Catalysts comprising thio-salalen ligands. Also, catalyst systems comprising the catalyst and an activator; methods to prepare the ligands, catalysts and catalyst systems; processes to polymerize olefins using the catalysts and/or catalyst systems; and the olefin polymers prepared according to the processes.

  含有硫代萨莱伦配体的催化剂。此外，还包括催化剂和活化剂组成的催化剂体系；制备配体、催化剂和催化剂体系的方法；使用催化剂和/或催化剂体系聚合烯烃的过程；以及根据这些过程制备的烯烃聚合物。
• CHIRAL IMIDODIPHOSPHATES AND DERIVATIVES THEREOF
  申请人：STUDIENGESELLSCHAFT KOHLE MBH

  公开号：US20140350268A1

  公开（公告）日：2014-11-27

  The invention relates to chiral imidodiphosphates and derivatives thereof having the general formula I, The compounds are suitable as chiral Brønsted acid catalysts, phase-transfer catalysts, chiral anions for organic salts, metal salts or metal complexes for catalysis.

  本发明涉及手性咪唑二磷酸酯及其衍生物，其具有一般式I，所述化合物适用于手性Brønsted酸催化剂、相转移催化剂、有机盐、金属盐或金属配合物的手性阴离子催化。