2-氨基-6-苯甲酰基-1-[(异丙基)磺酰基]-1H-苯并咪唑 | 63197-61-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-氨基-6-苯甲酰基-1-[(异丙基)磺酰基]-1H-苯并咪唑
• 英文名称: 1-isopropylsulfonyl-2-amino-6-benzoylbenzimidazole
• 英文别名: 6-benzoyl-1-<(1-methylethyl)sulfonyl>-1H-benzimidazol-2-amine；2-amino-1-(isopropylsulfonyl)-6-benzimidazolyl phenyl ketone；6-benzoyl-2-amino-1-isopropylsulfonylbenzimidazole；6-benzoyl-1-(1-methyl-ethanesulfonyl)-1H-benzoimidazol-2-ylamine；2-amino-6-benzoyl-1-[(isopropyl)sulfonyl]-1H-benzimidazole；2-amino-1-isopropylsulfonyl-(6)-benzoylbenzimidazole；2-Amino-6-benzoyl-1-((isopropyl)sulphonyl)-1H-benzimidazole；(2-amino-3-propan-2-ylsulfonylbenzimidazol-5-yl)-phenylmethanone
• CAS: 63197-61-5
• 化学式: C₁₇H₁₇N₃O₃S
• 分子量: 343.406
• InChiKey: SXUXQJLILGMLOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  103
• 氢给体数：
  1
• 氢受体数：
  5

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  2-氨基-6-苯甲酰基-1-[(异丙基)磺酰基]-1H-苯并咪唑 生成 韦罗肟
  参考文献：
  名称：

  WIKEL J. H.; PAGEL C. J.; DELONG D. C.; NELSON J. D.; WU C. Y. E.; PASCHA+, J. MED. CHEM., 1980, 23, NO 4, 368-372

  摘要：

  DOI：
• 作为产物：
  描述：

  3-(isopropylsulfonyl)amino-4-aminobenzophenone 生成 2-氨基-6-苯甲酰基-1-[(异丙基)磺酰基]-1H-苯并咪唑
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Olefinic benzimidazoles, formulations, and antiviral methods
  申请人：Eli Lilly and Company

  公开号：US04420479A1

  公开（公告）日：1983-12-13

  1-Substituted-2-amino-5(or 6) olefinic benzimidazoles and intermediates therefor are disclosed. The compounds are potent antiviral agents. Pharmaceutical formulations containing such compounds and a method of treating viral infections are provided.

  本文揭示了1-取代-2-氨基-5（或6）烯基苯并咪唑及其中间体。这些化合物是强效的抗病毒剂。本文提供了含有这些化合物的制药配方和治疗病毒感染的方法。
• Process for preparing a trans-6-propenyl benzimidazole
  申请人：Eli Lilly and Company

  公开号：US04424362A1

  公开（公告）日：1984-01-03

  This invention describes a process for selectively preparing trans-1-isopropylsulfonyl-2-amino-6-(1-phenyl-1-propenyl)benzimidazole by dehydrating the corresponding benzimidazole carbinol with certain specific acids.

  本发明描述了一种通过使用特定的酸脱水反应，选择性地制备反-1-异丙基磺酰基-2-氨基-6-(1-苯基-1-丙烯基)苯并咪唑的方法。
• 4-Nitrobenzophenone compounds
  申请人：Eli Lilly and Company

  公开号：US04483986A1

  公开（公告）日：1984-11-20

  A compound of the formula I ##STR1## and other compounds and process for preparing, which compounds are useful as intermediates.

  化合物I的化学式为 ##STR1## 以及其他化合物和制备方法，这些化合物是有用的中间体。
• Olefinic benzimidazoles
  申请人：ELI LILLY AND COMPANY

  公开号：EP0091795A1

  公开（公告）日：1983-10-19

  1-Substituted-2-amino-5(or 6) olefinic benzimidazoles and intermediates therefor are disclosed. The compounds are potent antiviral agents. Pharmaceutical formulations containing such compounds and a method of treating viral infections are provided.

  本研究公开了 1-取代-2-氨基-5（或 6）烯烃苯并咪唑及其中间体。这些化合物是强效抗病毒剂。还提供了含有此类化合物的药物制剂和治疗病毒感染的方法。
• Synthesis, Antiviral Activity, and Biological Properties of Vinylacetylene Analogs of Enviroxime
  作者：Frantz Victor、Thomas J. Brown、Kristina Campanale、Beverly A. Heinz、Lisa A. Shipley、Kenneth S. Su、Joseph Tang、Lori M. Vance、Wayne A. Spitzer

  DOI：10.1021/jm960718i

  日期：1997.5.1

  A series of vinylacetylene analogs of Enviroxime (1) was synthesized. The new compounds are potent inhibitors of poliovirus in tissue culture. Cross-sensitivity with Enviroxime-derived mutants shows that the new compounds have the same mechanism of action as Enviroxime, which involves the viral 3A protein. In studies with Rhesus monkeys, the p-fluoro derivative 12 was found to be unique in providing oral bioavailability. Metabolism studies using hepatic microsomes suggest that this procedure would be a useful in vitro method for selecting the appropriate animal model for testing oral absorption. Compound 12 was found to be efficacious by oral administration in treating a Coxsackie A21 infection in CD-1 mice.