2-hydroxy-9,10-dioxo-9,10-dihydro-anthracene-1-carboxylic acid | 374705-59-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 2-hydroxy-9,10-dioxo-9,10-dihydro-anthracene-1-carboxylic acid
• 英文别名: 2-Hydroxy-9,10-dioxo-9,10-dihydro-anthracen-1-carbonsaeure；2-Oxy-anthrachinon-carbonsaeure-(1)；o-Hydroxy-carboxyanthraquinone；2-hydroxy-9,10-dioxoanthracene-1-carboxylic acid
• CAS: 374705-59-6
• 化学式: C₁₅H₈O₅
• 分子量: 268.226
• InChiKey: GYEFSSIJYQDLOM-UHFFFAOYSA-N

物化性质

• 熔点：
  237 °C
• 沸点：
  508.6±50.0 °C(Predicted)
• 密度：
  1.577±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  91.7
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-hydroxy-9,10-dioxo-9,10-dihydro-anthracene-1-carboxylic acid 生成 2-羟基蒽醌
  参考文献：
  名称：

  de Diesbach; Gubser, Helvetica Chimica Acta, 1928, vol. 11, p. 1120

  摘要：

  DOI：
• 作为产物：
  描述：

  2-hydroxy-1-[(2,2,2-trichloro-acetylamino)-methyl]-anthraquinone 在 sodium hydroxide 、 氧气 作用下， 生成 2-hydroxy-9,10-dioxo-9,10-dihydro-anthracene-1-carboxylic acid
  参考文献：
  名称：

  de Diesbach; Gubser, Helvetica Chimica Acta, 1928, vol. 11, p. 1120

  摘要：

  DOI：

文献信息

• Multiple-Dose Pharmacokinetics of Atrasentan, an Endothelin-A Receptor Antagonist
  作者：Sandeep Dutta、Emil Samara、Wayne Lam、G. Granneman、Philip T. Leese、R. Padley

  DOI：10.2165/00044011-200121020-00005

  日期：——

  To determine the single- and multiple-dose pharmacokinetics of atrasentan, a highly selective endothelin-A receptor antagonist that is currently being investigated for the treatment of prostate cancer and cardiovascular disorders. Phase I, randomised, placebo-controlled, double-blind, single-and multiple-dose study of orally administered atrasentan. Single daily oral doses of 1, 5, 10, 15, 20, 25, 30 or 40mg of atrasentan or placebo were administered to healthy male volunteers (n = 72; six active and three placebo per drug administration group) on study day 1 and days 3 to 9. Atrasentan plasma concentration-time profiles for day 1 and day 9 were used to assess atrasentan pharmacokinetics. Except for the 1mg group, atrasentan plasma concentrations increased rapidly after single and multiple administration, declining thereafter biexponentially with a study-wide harmonic mean (pseudo-SD) half-life of 21 (12) hours and mean (SD) apparent total body clearance (CL/F) of 28 (9.8) L/h. For the 1mg group, there was no apparent distribution phase and the absorption was slower. Drug administration in the 40mg group was discontinued prematurely because of adverse events. Except for lower-than-predicted maximum plasma concentration (Cmax) values for the 1mg group, drug exposure (Cmax, trough concentration and area under the concentration-time curve) increased linearly with dose, and CL/F values were similar across groups, after single- and multiple-dose administration. Steady state was reached within 4 days of drug administration. The pharmacokinetics of atrasentan are dose- and time-independent after single-and multiple-dose administration over the range of 1 to 30 mg/day.

  确定阿曲库铵的单剂量和多剂量药代动力学，该药是一种高度选择性的内源性肽A受体拮抗剂，目前正在研究用于治疗前列腺癌和心血管疾病。进行了一项阶段I、随机、安慰剂对照、双盲的单剂量和多剂量研究，口服给药阿曲库铵。健康男性志愿者（n = 72；每个药物给药组6名活性和3名安慰剂）在研究的第1天和第3到第9天服用1、5、10、15、20、25、30或40 mg的阿曲库铵或安慰剂的每日单剂量。第1天和第9天的阿曲库铵血浆浓度-时间曲线用于评估阿曲库铵的药代动力学。除了1 mg组外，阿曲库铵血浆浓度在单次和多次给药后迅速上升，随后以双指数方式下降，研究全体的调和平均（伪标准差）半衰期为21（12）小时，平均（标准差）明显的全身清除率（CL/F）为28（9.8）L/h。在1 mg组中，没有明显的分布相，吸收较慢。由于不良事件，40 mg组的药物给药提前停止。除1 mg组的最大血浆浓度（Cmax）值低于预测外，药物暴露（Cmax、谷浓度和浓度-时间曲线下面积）随着剂量线性增加，且在单次和多次给药后，各组的CL/F值相似。稳态在给药后4天内达到。阿曲库铵的药代动力学在1至30 mg/天的范围内，在单次和多次给药后均与剂量和时间无关。
• DE507049
  申请人：——

  公开号：——

  公开（公告）日：——
• Hammerschlag, Chemische Berichte, 1878, vol. 11, p. 88
  作者：Hammerschlag

  DOI：——

  日期：——
• Monitoring of frozen soil hydrology in macro-scale in the Qinghai-Xizang Plateau
  作者：Yongjian Ding、Baisheng Ye、Shiying Liu、Yongping Shen、Shaoling Wang、Meixie Yang

  DOI：10.1007/bf02887190

  日期：2000.6

  Monitoring of frozen soil hydrology in macro-scale was performed by Chinese and Japanese scientists from 1997 to 1998. Quality measured data were obtained. Measured data on soil moisture and temperature are preliminarily analyzed. Based on profiles of soil temperature and moisture in individual measured sites, intra-annual freezing and melting process of soil is discussed. Maximum frozen and thawed depths and frozen days in various depths are estimated. The work emphasized the spatial distribution on soil temperature and moisture in macro-scale and the effect of topography on conditions of soil water and heat.
• ARYLALKYL ESTERS OF 4,5-DIHYDROXY-9,10-DIHYDRO-9,10-DIOXO-2-ANTHRACENECARBOXYLIC ACID HAVING THERAPEUTICAL ACTIVITY
  申请人：ISTITUTO GENTILI S.p.A.

  公开号：EP0537313B1

  公开（公告）日：1996-01-17