tert-butyl 2,6-dimethylbenzylcarbamate | 1314538-60-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tert-butyl 2,6-dimethylbenzylcarbamate
• 英文别名: Carbamic acid, N-[(2,6-dimethylphenyl)methyl]-, 1,1-dimethylethyl ester；tert-butyl N-[(2,6-dimethylphenyl)methyl]carbamate
• CAS: 1314538-60-7
• 化学式: C₁₄H₂₁NO₂
• 分子量: 235.326
• InChiKey: VOBHZXMVKLUZCH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  tert-butyl ((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)carbamate 在 2-双环己基膦-2',6'-二甲氧基联苯 、 potassium hydrogen bifluoride 、 palladium diacetate 、 potassium carbonate 作用下， 以 甲醇 、 水 、 甲苯 为溶剂， 反应 22.0h， 生成 tert-butyl 2,6-dimethylbenzylcarbamate
  参考文献：
  名称：

  Synthesis and Suzuki–Miyaura Cross-Coupling Reactions of Potassium Boc-Protected Aminomethyltrifluoroborate with Aryl and Hetaryl Halides

  摘要：

  Potassium Boc-protected aminomethyltrifluoroborate, a primary aminomethyl equivalent, was synthesized successfully through a "one-pot" process. With this trifluoroborate, Suzuki-Miyaura cross-coupling reactions were investigated with a variety of both aryl and hetaryl chlorides in good to excellent yields.

  DOI：

  10.1021/ol2014768

文献信息

• Suzuki–Miyaura Cross-Coupling Reactions of Potassium Boc-Protected Aminomethyltrifluoroborate with Aryl and Hetaryl Mesylates
  作者：Gary A. Molander、Inji Shin

  DOI：10.1021/ol301221p

  日期：2012.6.15

  Palladium-catalyzed Suzuki-Miyaura cross-coupling reactions were studied with potassium Boc-protected aminomethyltrifluoroborate through C-O activation of various mesylate derivatives to afford the corresponding products in moderate to good yields.
• Synthesis and Suzuki–Miyaura Cross-Coupling Reactions of Potassium Boc-Protected Aminomethyltrifluoroborate with Aryl and Hetaryl Halides
  作者：Gary A. Molander、Inji Shin

  DOI：10.1021/ol2014768

  日期：2011.8.5

  Potassium Boc-protected aminomethyltrifluoroborate, a primary aminomethyl equivalent, was synthesized successfully through a "one-pot" process. With this trifluoroborate, Suzuki-Miyaura cross-coupling reactions were investigated with a variety of both aryl and hetaryl chlorides in good to excellent yields.