1,8-bis-(N-methylanilino)-octane | 85802-70-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1,8-bis-(N-methylanilino)-octane
• 英文别名: N,N'-dimethyl-N,N'-diphenyl-1,8-octanediamine；N1,N8-dimethyl-N1,N8-diphenyloctane-1,8-diamine；N,N'-dimethyl-N,N'-diphenyloctane-1,8-diamine
• CAS: 85802-70-6
• 化学式: C₂₂H₃₂N₂
• 分子量: 324.509
• InChiKey: LZUNLLPIFRXPPX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  24
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,8-bis-(N-methylanilino)-octane 、 3-[4-(二丁基氨基)苯基]-4-羟基环丁-3-烯-1,2-二酮 在 原甲酸三乙酯 作用下， 以 异丙醇 为溶剂， 反应 6.0h， 以42%的产率得到2-[4-(Dibutylamino)phenyl]-4-[4-[8-[[4-[3-[4-(dibutylamino)phenyl]-2-oxido-4-oxocyclobut-2-en-1-ylidene]cyclohexa-2,5-dien-1-ylidene]-methylazaniumyl]octyl-methylazaniumylidene]cyclohexa-2,5-dien-1-ylidene]-3-oxocyclobuten-1-olate
  参考文献：
  名称：

  Metallo Supramolecular Assemblies of Bis-squaraines by Allosteric Ca²⁺ Ion Binding

  摘要：

  Alkyl chain tethered bis-squaraines bind to Ca2+ ions through the participation of the negatively charged oxygen of the central cyclobutene moiety to form folded H-type aggregates. The initially formed Ca2+ complex is preorganized to facilitate cooperative allosteric binding of Ca2+, resulting in the formation of extended supramolecular arrays. The electronic absorption, IR, and ESI-MS studies support the formation of metallo supramolecular architectures of the folded H-type dimers of the bis-squaraines.

  DOI：

  10.1021/ol070582q
• 作为产物：
  描述：

  1,8-二溴辛烷 、 N-甲基苯胺 在 三乙胺 作用下， 以 苯 为溶剂， 反应 24.0h， 以84%的产率得到1,8-bis-(N-methylanilino)-octane
  参考文献：
  名称：

  Metallo Supramolecular Assemblies of Bis-squaraines by Allosteric Ca²⁺ Ion Binding

  摘要：

  Alkyl chain tethered bis-squaraines bind to Ca2+ ions through the participation of the negatively charged oxygen of the central cyclobutene moiety to form folded H-type aggregates. The initially formed Ca2+ complex is preorganized to facilitate cooperative allosteric binding of Ca2+, resulting in the formation of extended supramolecular arrays. The electronic absorption, IR, and ESI-MS studies support the formation of metallo supramolecular architectures of the folded H-type dimers of the bis-squaraines.

  DOI：

  10.1021/ol070582q

文献信息

• A biphosphine copolymer encapsulated single-site Rh catalyst for heterogeneous regioselective hydroaminomethylation of alkenes
  作者：Kang Zhao、Hongli Wang、Xinzhi Wang、Xinjiang Cui、Feng Shi

  DOI：10.1039/d2cc02469a

  日期：——

  organic polymer catalyst with in situ encapsulated single-site Rh (Rh@CPOL-DPMphos&p-3vPPh3) was developed and employed in heterogeneous hydroaminomethylation of alkenes, affording the corresponding amines in good to excellent regioselectivity and catalytic activity by a one-pot method. The combined actions of hierarchical pore confinement and the biphosphine ligand derived from the POP catalyst contributed

  开发了一种新型多孔有机聚合物催化剂，原位包封单中心 Rh (Rh@CPOL-DPMphos& p -3vPPh 3 )，并将其用于烯烃的非均相氢氨基甲基化反应，从而使相应的胺具有良好至优异的区域选择性和催化活性。 -锅法。分级孔限制和源自 POP 催化剂的双膦配体的联合作用有助于提高区域选择性。
• Heterogeneous bimetallic Pt–Sn/γ-Al2O3 catalyzed direct synthesis of diamines from N-alkylation of amines with diols through a borrowing hydrogen strategy
  作者：Liandi Wang、Wei He、Kaikai Wu、Songbo He、Chenglin Sun、Zhengkun Yu

  DOI：10.1016/j.tetlet.2011.10.100

  日期：2011.12

  Direct synthesis of diamines has been efficiently realized from the N-alkylation of amines with diols by means of heterogeneous bimetallic Pt-Sn/gamma-Al2O3 catalyst (0.5 wt % Pt, molar ratio Pt:Sn = 1:3) through a 'Borrowing Hydrogen' strategy under ligand-free conditions. The present methodology provides an environmentally benign route to diamines. (C) 2011 Elsevier Ltd. All rights reserved.