9-oxo-fluorene-2,7-disulfonic acid | 361444-25-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 9-oxo-fluorene-2,7-disulfonic acid
• 英文别名: 9-Oxo-fluoren-2,7-disulfonsaeure；Fluorenon-disulfonsaeure-(2.7)；9-Oxo-9H-fluoren-2,7-disulfonsaeure；Fluorenon-2,7-disulfonsaeure；9-Oxofluorene-2,7-disulfonic acid
• CAS: 361444-25-9
• 化学式: C₁₃H₈O₇S₂
• 分子量: 340.334
• InChiKey: BIYCFCXLXCGDFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  143
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  9-oxo-fluorene-2,7-disulfonic acid 生成 [1,1-联苯]-2-羧酸, 4,4-二羟基
  参考文献：
  名称：

  Courtot, Annales de Chimie (Cachan, France), 1930, vol. <10> 14, p. 52,55, 95

  摘要：

  DOI：
• 作为产物：
  描述：

  9H-fluorene-2,7-disulfonic acid dipotassium salt 在 potassium permanganate 作用下， 生成 9-oxo-fluorene-2,7-disulfonic acid
  参考文献：
  名称：

  双碱性取代的多环芳族化合物。一类新的抗病毒药物。2.芴酮，芴醇和芴的噻咯烷酮和相关的二元醚。

  摘要：

  DOI：

  10.1021/jm00254a020

文献信息

• [EN] COMPOUNDS, COMPOSITIONS, AND METHODS FOR TREATING, AMELIORATING, OR PREVENTING BACTERIAL INFECTIONS<br/>[FR] COMPOSÉS, COMPOSITIONS ET MÉTHODES POUR LE TRAITEMENT, L'AMÉLIORATION OU LA PRÉVENTION DES INFECTIONS BACTÉRIENNES
  申请人：BAYLOR COLLEGE MEDICINE

  公开号：WO2020257734A1

  公开（公告）日：2020-12-24

  The disclosure relates, in certain aspects, to the discovery of compounds that can be used to inhibit β-lactamases, such as but not limited to OXA enzymes, such as but not limited to OXA-48. In certain embodiments, these compounds can be used to inhibit activity of β-lactamases in vitro and in vivo.

  该披露涉及在某些方面发现的化合物，可以用于抑制β-内酰胺酶，例如但不限于OXA酶，例如但不限于OXA-48。在某些实施例中，这些化合物可以用于体外和体内抑制β-内酰胺酶的活性。
• Squarylium dye and composition containing same
  申请人：TOYO INK SC HOLDINGS CO., LTD.

  公开号：US11512204B2

  公开（公告）日：2022-11-29

  A squarylium dye [A] that has high invisibility, i.e., exhibits low absorption in the visible light region (400 nm to 750 nm), has excellent near-infrared absorption capability and high light resistance, tends not to exhibit aggregations, and has specific X-ray diffraction peaks; and an image-forming material and the like containing the squarylium dye [A] having said characteristics. The problem is solved by a squarylium dye [A] having specific X-ray diffraction peaks represented by general formula (1). Moreover, the problem is also solved by various materials containing the squarylium dye [A].

  一种具有高隐蔽性的鳞片染料[A]，即在可见光区（400 nm 至 750 nm）吸收率低，具有优异的近红外吸收能力和高耐光性，不易聚集，并具有特定的 X 射线衍射峰；以及一种含有具有上述特性的鳞片染料[A]的图像形成材料等。具有通式（1）表示的特定 X 射线衍射峰的鳞片染料[A]解决了这一问题。此外，含有鳞片染料[A]的各种材料也解决了这一问题。
• Synthesis of substituted 5[H]phenanthridin-6-ones as potent poly(ADP-ribose)polymerase-1 (PARP1) inhibitors
  作者：Jia-He Li、Larisa Serdyuk、Dana V. Ferraris、Ge Xiao、Kevin L. Tays、Paul W. Kletzly、Weixing Li、Susan Lautar、Jie Zhang、Vincent J. Kalish

  DOI：10.1016/s0960-894x(01)00281-5

  日期：2001.7

  1-, 2-, 3-, 4-, 8-, or 10-Substituted 5(H)phenanthridin-6-ones were synthesized and found to be potent PARP1 inhibitors. Among the 28 compounds prepared. some showed not only low IC50 values (compound 1b, 10 nM) but also desirable water solubility characteristics. These properties, which are superior to the common PARP1 inhibitors such as benzamides and isoquinolin-1-ones, are essential for potential therapeutic usage. The variety of compounds allows SAR analysis of favored substituents and substituted positions on 5(H)phenanthridin-6-one ring. (C) 2001 Elsevier Science Ltd. All rights reserved.
• Schmidt; Schultz, Justus Liebigs Annalen der Chemie, 1881, vol. 207, p. 333
  作者：Schmidt、Schultz

  DOI：——

  日期：——
• Courtot; Geoffroy, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1924, vol. 178, p. 2261
  作者：Courtot、Geoffroy

  DOI：——

  日期：——