3-fluoren-1-yl-propionic acid | 15914-16-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 3-fluoren-1-yl-propionic acid
• 英文别名: 3-Fluoren-1-yl-propionsaeure；3-(9H-Fluorenyl)-propionic acid；β-Fluorenyl-(1)-propionsaeure；3-(9H-fluoren-1-yl)propanoic acid
• CAS: 15914-16-6
• 化学式: C₁₆H₁₄O₂
• 分子量: 238.286
• InChiKey: MNNOANVPZKDZMZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-fluoren-1-yl-propionic acid 在 甲基碘化镁 、 PPA 、 苯 作用下， 生成 3-methyl-1,10-dihydro-cyclopenta[a]fluorene
  参考文献：
  名称：

  1,2-Cyclopentenofluorenes and Some Derivatives of 1,2,3,4-Tetrahydrofluorene

  摘要：

  DOI：

  10.1021/ja01593a048
• 作为产物：
  描述：

  9-芴酮-1-羧酸 在 哌啶 、 1,4-二氧六环 、 吡啶 、 palladium on activated charcoal 、 sodium amalgam 、 氯化亚砜 、 水 、 铂 、 xylene 作用下， 生成 3-fluoren-1-yl-propionic acid
  参考文献：
  名称：

  1,2-Cyclopentenofluorenes and Some Derivatives of 1,2,3,4-Tetrahydrofluorene

  摘要：

  DOI：

  10.1021/ja01593a048

文献信息

• Constituents of high-boiling petroleum distillates. Part X. 1,2,7,8-Tetramethylfluorene and methylbenzo[a]fluorenes
  作者：W. Carruthers、H. N. M. Stewart

  DOI：10.1039/j39670000556

  日期：——

  A hydrocarbon isolated from a fraction of a Kuwait mineral oil has been identified by synthesis as 1,2,7,8-tetramethylfluorene. A crystalline mixture of methylbenzo[a]fluorenes from an Oklahoma oil is shown by gas chromatography to contain at least six components, four of which have retention times coincident with those of the 1-, 3-, 4-, and 10-methyl isomers. Syntheses of 1-, 3-, and 4-methylbenzo[a]fluorene

  从科威特矿物油的一部分中分离出的烃已通过合成鉴定为1,2,7,8-四甲基芴。气相色谱显示，来自俄克拉荷马州油的甲基苯并[ a ]芴的结晶混合物包含至少六个组分，其中四个的保留时间与1-，3-，4-和10-甲基异构体的保留时间一致。描述了1-，3-和4-甲基苯并[ a ]芴的合成。
• 2-Furancarboxylic acid hydrazides and pharmaceutical compositions containing the same
  申请人：Fujii Akihito

  公开号：US20050171196A1

  公开（公告）日：2005-08-04

  The present invention provides 2-furancarboxylic acid hydrazide compounds represented by General Formula (I) below, and prodrugs, physiologically acceptable salts, hydrates, solvates thereof, methods for producing them and pharmaceutical compositions containing them: wherein A is a group represented by Formula (a) or the like: (wherein either R 4 or R 5 represents cyano, nitro or the like, and the other represents a hydrogen atom or the like); either R 1 or R 2 represents a group: -D-(X)m-R 6 or the like, and the other represents a group: -E-(Y)n-R 7 , hydrogen atom, aryl or the like; R 3 is a hydrogen atom or the like; D and E independently represent aryl; X and Y independently represent O or the like; R 6 and R 7 independently represent alkyl, aryl, arylalkyl or the like; and m and n are independently 0 or 1, provided that the aryl is optionally substituted. Such compounds exhibit a potent antagonistic activity on glucagon receptor and are of use as preventive and/or therapeutic agents for symptoms and diseases in which glucagon is involved.

  本发明提供了由下列通式（I）表示的2-呋喃羧酸肼化合物，以及它们的前药、生理上可接受的盐、水合物、溶剂化物、制备方法和含有它们的制药组合物：其中A是由式（a）或类似式表示的基团：（其中R4或R5代表氰基、硝基或类似物，另一个代表氢原子或类似物）；R1或R2代表基团：-D-(X)m-R6或类似物，另一个代表基团：-E-(Y)n-R7、氢原子、芳基或类似物；R3是氢原子或类似物；D和E独立地表示芳基；X和Y独立地表示O或类似物；R6和R7独立地表示烷基、芳基、芳基烷基或类似物；m和n独立地表示0或1，但芳基可选择性地被取代。这些化合物表现出强大的胰高血糖素受体拮抗活性，并且可用作预防和/或治疗胰高血糖素参与的症状和疾病的药物。
• HELICENE DERIVATIVE, AXIALLY ASYMMETRIC AMINO ACID, AMINE OR AMINOALCOHOL DERIVATIVE, PERYLENE DERIVATIVE OR SALT THEREOF, AND METHODS FOR PRODUCING SAME
  申请人：Furuta Takumi

  公开号：US20110251393A1

  公开（公告）日：2011-10-13

  The invention provides a helicene derivative, axially chiral amino acid, amine or amino alcohol derivative, and azaperylene, such as compounds represented by Formulae (I), (I′), (II), (II′), and (III): and a method for producing the same.

  本发明提供了螺环衍生物，轴向手性氨基酸，胺或氨基醇衍生物和氮杂蒽衍生物，例如由公式（I），（I'），（II），（II'）和（III）表示的化合物以及其制备方法。
• PEPTIDIC COMPOUND AND USE OF SAME
  申请人：Suenaga Kiyotake

  公开号：US20120122797A1

  公开（公告）日：2012-05-17

  An object of the present invention is to provide a novel compound having an antitumor/anticancer effect. Specifically, the present invention provides a compound represented by Formula (I), a derivative thereof or a salt of the same. In Formula (I), R 1 represents an alkyl group, an alkenyl group, a cycloalkyl group, an amino group, a monoalkylamino group, a dialkylamino group, an aryl group, a heteroaryl group, an aralkyl group or an alkoxy group; R 2 represents a substituted or unsubstituted amino group or a substituted or unsubstituted nitrogen-containing heterocyclic group; and R 3 represents hydrogen, halogen, alkyl, methoxy, cyano, trifluoromethyl, acetylamino or amino. In Formula (I), N-Me-Ala may be substituted with N-Me-Gly, N-Me-Ser, N-Me-Thr, Ala, Gly, Ser or Thr; N-Me-Phe may be substituted with Phe, Tyr or N-Me-Tyr; and D-Leu may be substituted with L-Leu.

  本发明的目的是提供一种具有抗肿瘤/抗癌作用的新化合物。具体而言，本发明提供由式（I）表示的化合物，其衍生物或其盐。在式（I）中，R1表示烷基，烯基，环烷基，氨基，单烷基氨基，双烷基氨基，芳基，杂环芳基，芳基烷基或烷氧基；R2表示取代或未取代的氨基或取代或未取代的含氮杂环基；R3表示氢，卤素，烷基，甲氧基，氰基，三氟甲基，乙酰氨基或氨基。在式（I）中，N-Me-Ala可以被N-Me-Gly，N-Me-Ser，N-Me-Thr，Ala，Gly，Ser或Thr替代；N-Me-Phe可以被Phe，Tyr或N-Me-Tyr替代；D-Leu可以被L-Leu替代。
• 2-FURANCARBOXYLIC ACID HYDRAZIDES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
  申请人：DAINIPPON PHARMACEUTICAL CO., LTD.

  公开号：EP1489077A1

  公开（公告）日：2004-12-22

  The present invention provides 2-furancarboxylic acid hydrazide compounds represented by General Formula (I) below, and prodrugs, physiologically acceptable salts, hydrates, solvates thereof, methods for producing them and pharmaceutical compositions containing them: wherein A is a group represented by Formula (a) or the like: (wherein either R4 or R5 represents cyano, nitro or the like, and the other represents a hydrogen atom or the like); either R1 or R2 represents a group: -D-(X)m-R6 or the like, and the other represents a group: -E-(Y)n-R7, hydrogen atom, aryl or the like; R3 is a hydrogen atom or the like; D and E independently represent aryl; X and Y independently represent 0 or the like; R6 and R7 independently represent alkyl, aryl, arylalkyl or the like; and m and n are independently 0 or 1, provided that the aryl is optionally substituted. Such compounds exhibit a potent antagonistic activity on glucagon receptor and are of use as preventive and/or therapeutic agents for symptoms and diseases in which glucagon is involved.

  本发明提供由通式表示的 2-呋喃羧酸酰肼化合物 (I)代表的2-呋喃羧酸酰肼化合物及其原药、生理上可接受的盐、水合物、溶液，以及生产它们的方法和含有它们的药物组合物： 其中 A 是由式（a）代表的基团或类似基团： (其中 R4 或 R5 代表氰基、硝基或类似物，另一个代表氢原子或类似物）； R1 或 R2 代表一个基团：-D-(X)m-R6 或类似基团，另一个代表一个基团：-E-(Y)n-R7、氢原子、芳基或类似基团； R3 是氢原子或类似物； D 和 E 各自代表芳基； X 和 Y 独立地代表 0 或类似物； R6 和 R7 独立地代表烷基、芳基、芳烷基或类似物；以及 m 和 n 独立地为 0 或 1，前提是芳基被任选取代。此类化合物对胰高血糖素受体具有强效的拮抗活性，可用作胰高血糖素相关症状和疾病的预防和/或治疗药物。