<2-Chlor-4,5-dimethoxy-phenyl>-essigsaeure-methylester | 6834-54-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: <2-Chlor-4,5-dimethoxy-phenyl>-essigsaeure-methylester
• 英文别名: <6-Chlor-3,4-dimethoxy-phenyl>-essigsaeure-methylester；(6-Chlor-3,4-dimethoxy-phenyl)-essigsaeure-methylester；Methyl (2-chloro-4,5-dimethoxyphenyl)acetate；methyl 2-(2-chloro-4,5-dimethoxyphenyl)acetate
• CAS: 6834-54-4
• 化学式: C₁₁H₁₃ClO₄
• 分子量: 244.675
• InChiKey: AXHDWRXIGVQUJY-UHFFFAOYSA-N

物化性质

• 沸点：
  315.7±37.0 °C(Predicted)
• 密度：
  1.210±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  <2-Chlor-4,5-dimethoxy-phenyl>-essigsaeure-methylester 在 吡啶 、 三溴化磷 作用下， 以 苯 为溶剂， 生成 1-(2-bromoethyl)-2-chloro-4,5-dimethoxybenzene
  参考文献：
  名称：

  Studies in the Tetrahydronaphthalene Series: Synthesis of 1-Methyl-1-ethyl-2-n-propyl-7,8-dimethoxy-1,2,3,4-tetrahydronaphthalene

  摘要：

  DOI：

  10.1021/jo01065a014
• 作为产物：
  描述：

  3,4-二甲氧基苯乙酸甲酯 在 4 A molecular sieve 、 五氯化钼 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以55%的产率得到dimethyl 2,2'-(4,4',5,5'-tetramethoxybiphenyl-2,2'-diyl)diacetate
  参考文献：
  名称：

  The synthesis of 2′,2′-bis-benzylisoquinolines and their cytostatic activities

  摘要：

  The novel laudanosine dimers in which two laudanosine units are linked via a C-2 ' biaryl bond have been prepared by a sequence that involves formation of the biaryl bond first and then formation of the isoquinoline rings. Two of these compounds showed higher cytostatic activity on three cancer cell lines than thalicarpine. Crown Copyright (c) 2007 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.08.083

文献信息

• Studies in the Tetrahydronaphthalene Series: Synthesis of 1-Methyl-1-ethyl-2-n-propyl-7,8-dimethoxy-1,2,3,4-tetrahydronaphthalene
  作者：LEWIS J. SARGENT

  DOI：10.1021/jo01065a014

  日期：1961.6
• The synthesis of 2′,2′-bis-benzylisoquinolines and their cytostatic activities
  作者：Stephen R. Taylor、Alison T. Ung、Stephen G. Pyne

  DOI：10.1016/j.tet.2007.08.083

  日期：2007.11

  The novel laudanosine dimers in which two laudanosine units are linked via a C-2 ' biaryl bond have been prepared by a sequence that involves formation of the biaryl bond first and then formation of the isoquinoline rings. Two of these compounds showed higher cytostatic activity on three cancer cell lines than thalicarpine. Crown Copyright (c) 2007 Published by Elsevier Ltd. All rights reserved.