2-氨基苯并噻唑-6-磺酸 | 21951-32-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 中文名称: 2-氨基苯并噻唑-6-磺酸
• 英文名称: 2-aminobenzothiazole-6-sulfonic acid
• 英文别名: 2-aminobenzthiazole-6-sulfonic acid；2-Amino-benzothiazol-6-sulfonsaeure；2-amino-6-sulfobenzothiazole；2-Iminio-2,3-dihydro-1,3-benzothiazole-6-sulfonate；2-amino-1,3-benzothiazol-3-ium-6-sulfonate
• CAS: 21951-32-6
• 化学式: C₇H₆N₂O₃S₂
• mdl: MFCD00071759
• 分子量: 230.268
• InChiKey: CKAGMVXJHAZUBL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  130
• 氢给体数：
  2
• 氢受体数：
  6

安全信息

• 海关编码：
  2934999090

反应信息

• 作为反应物：
  描述：

  2-氨基苯并噻唑-6-磺酸 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.12h， 生成 2-[2-(2,4-Dichlorophenyl)-2,5-dimethyl-4-oxo-1,3-thiazolidin-3-yl]-1,3-benzothiazole-6-sulfonic acid
  参考文献：
  名称：

  Mistry, Ketan; Desai, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2006, vol. 45, # 7, p. 1762 - 1766

  摘要：

  DOI：
• 作为产物：
  描述：

  2-氨基苯并噻唑 在 硫酸 作用下， 生成 2-氨基苯并噻唑-6-磺酸
  参考文献：
  名称：

  Wang et al., Journal of the Chinese Chemical Society, 1948, vol. 15, p. 208,212

  摘要：

  DOI：

文献信息

• NOVEL AZO COMPOUND OR SALT, INK COMPOSITION CONTAINING SUCH AZO COMPOUND, AND COLORED MATERIAL
  申请人：NIPPON KAYAKU KABUSHIKI KAISHA

  公开号：EP1837377A1

  公开（公告）日：2007-09-26

  [Method for solving the problems] The present invention relates to an azo compound represented by the following Formula (1) in free acid form or a salt thereof, (wherein, D represents a residual group of aromatic ring or heterocyclic diazo components, R1 represents a hydrogen atom, a C1 to C4 alkyl group or a trifluoromethyl group, R2 represents a hydrogen atom, a cyano group or a carbamoyl group, R3, R4, R5 and R6 may be the same or different respectively and each represents a hydrogen atom, a C1 to C4 alkyl group substituted by a sulfonic acid group or a carboxyl group) and an ink composition characterized by comprising the same, and said composition is excellent in storage stability, exhibits orange color by itself and hue with highly vividness when used for inkjet recording, provides strong fastnesses such as light fastness and ozone fastness of a recorded article, and is suitable for inkjet recording.

  本发明涉及一种以游离酸形式或其盐形式表示的偶氮化合物，其由以下式（1）表示， （其中，D代表芳香环或杂环偶氮组分的残基，R1代表氢原子、C1到C4烷基或三氟甲基，R2代表氢原子、氰基或氨基甲酰基，R3、R4、R5和R6可以分别相同或不同，每个代表氢原子、由磺酸基或羧基取代的C1到C4烷基）以及由此组成的油墨组合物，所述组合物在储存稳定性方面表现出色，单独呈橙色，并在用于喷墨记录时具有高度生动的色调，提供了记录物品的耐光性和耐臭氧性等强大的牢固性，并适用于喷墨记录。
• [EN] BROADSPECTRUM 2-AMINO-BENZOTHIAZOLE SULFONAMIDE HIV PROTEASE INHIBITORS<br/>[FR] INHIBITEURS BROADSPECTRUM 2-AMINO-BENZOTHIAZOLE SULFONAMIDE HIV PROTEASE INHIBITORS
  申请人：TIBOTEC PHARM LTD

  公开号：WO2004014371A1

  公开（公告）日：2004-02-19

  The present invention relates to the use of 2-amino-benzothiazoles, having the formula (I) wherein R1 is hexahydrofuro[2,3-b]furanyl, tetrahydrofuranyl, oxazolyl, thiazolyl, pyridinyl, or phenyl optionally substituted with one or more substituents independently selected from C1-6-alkyl, hydroxy, amino, halogen, aminoC1-4-alkyl and mono-or di(C1-4alkyl)amino; R2 is hydrogen or C1-6alkyl; L is a direct bond, -0-, C1-6 alkanediyl-O- or -O-C1-6alkanediyl; R3 is phenylC1-4alkyl; R4 is C1-6alkyl; R5 is hydrogen or C1-6alkyl; R6 is hydrogen or C1-6alkyl; in the manufacture of a medicament useful for inhibiting mutant HIV protease in a mammal infected with said mutant HIV protease. It also relates to novel compounds of formula (I).

  本发明涉及使用2-氨基苯并噻唑，其具有式（I），其中R1为六氢呋喃[2,3-b]呋喃基，四氢呋喃基，噁唑基，噻唑基，吡啶基或苯基，可选地取代一个或多个取代基，独立选择自C1-6-烷基，羟基，氨基，卤素，氨基C1-4-烷基和单或双（C1-4烷基）氨基; R2为氢或C1-6烷基; L为直接键，-0-，C1-6烷二基-O-或-O-C1-6烷二基; R3为苯基C1-4烷基; R4为C1-6烷基; R5为氢或C1-6烷基; R6为氢或C1-6烷基; 用于制造一种药物，有利于抑制患有该突变HIV蛋白酶的哺乳动物中的突变HIV蛋白酶。它还涉及式（I）的新化合物。
• Tint compositions useful for providing coloration to aqueous and non-aqueous liquids
  申请人：MILLIKEN RESEARCH CORPORATION

  公开号：EP0369599A1

  公开（公告）日：1990-05-23

  A two component tint composition is provided which comprises as a first component, a colorant of the formula: wherein X is a polar group selected from sulfonic acids, sulfonic acid salts, sulfonamides, sulfonates, carboxylic acids, carboxylic acid salts, carboxylic acid amides, carboxylic aldehydes, carboxylic acid esters, ureas, thioureas, nitro groups, hydroxy groups, polyethers, and hydroxyalkylethers; R₁ is selected from nitrogen, oxygen, sulfur, or a sulfur, or a sulfur-containing divalent linking group; R₂ is hydrogen or a lower alkyl group; a is an integer of from 2-10; b is an integer of from 2-10; c and d are each independently selected from one or two; A is a chromophore selected from nitro, nitroso, monazo, diazo, diarylmethane, triarylmethane, acridine, methine, thiazole, indamine, oxazine, or anthraquinone; and B is -H, -alkyl, or -alkyl carboxylate; and as a second component a diluent selected from alkoxylated fatty acids and long chain alcohols, the weight ratio of diluent to colorant being from about 2.5 to about 5 parts diluent to 1 part colorant.

  提供了一种由两个组分组成的色调配方，其中第一组分是具有以下化学式的着色剂：其中X是从磺酸、磺酸盐、磺酰胺、磺酸盐、羧酸、羧酸盐、羧酸酰胺、羧醛、羧酸酯、尿素、硫脲、硝基、羟基、聚醚和羟基烷醚中选择的极性基团；R₁是从氮、氧、硫或硫或含硫的双价连接基中选择的；R₂是氢或较低的烷基；a为2-10的整数；b为2-10的整数；c和d各自独立地选择为1或2；A是从硝基、亚硝基、单偶氮、双偶氮、二芳基甲烷、三芳基甲烷、吖啶、甲烷、噻唑、吲哚胺、噁唑或蒽醌中选择的色团；B是-H，-烷基或-烷基羧酸酯；作为第二组分的稀释剂选择了烷基化脂肪酸和长链醇，稀释剂与着色剂的重量比为约2.5至约5份稀释剂对1份着色剂。
• Microbial screening of novel synthesized formazans having amide linkagesΦ
  作者：Krunal G. Desai、Kishor R. Desai

  DOI：10.1002/jhet.5570430440

  日期：2006.7

  Formazans 5(a-j) have been prepared by the condensation between schiff base 3 and diazonium salt of substituted 2-amino benzothiazole 4(a-j). The intermediate schiff base 3 was synthesized by the condensation of p-nitrobenzolyhydrazide 1 with thiophene-2-aldehyde 2. All the compounds have been screened for their antifungal activity against Candida albicans (ATCC-64550), Candida krusei (ATCC-14243)

  甲臜5（AJ）已经制备由席夫碱之间的缩合3和苯并噻唑取代的2-氨基的重氮盐4（AJ） 。中间席夫碱3是通过对硝基苯甲酰肼1与噻吩-2-醛2的缩合反应合成的。筛选了所有化合物对白色念珠菌（ATCC -64550），克鲁斯假丝酵母（ATCC-14243）和副念珠菌（ATCC-22019）的抗真菌活性以及对大肠杆菌（ATCC-6538），金黄色葡萄球菌（ATCC ）的抗菌活性-6538），铜绿假单胞菌（ATCC-1539）和枯草芽孢杆菌（ATCC-6633）。合成化合物5（aj）的结构已根据其元素分析和光谱数据（UV，IR，1 H NMR，13 C NMR和质量）进行了表征。
• Broadspectrum 2-amino-benzothiazole sulfonamide hiv protease inhibitors
  申请人：Surleraux Nestor Ghislain Dominique Louis

  公开号：US20050267156A1

  公开（公告）日：2005-12-01

  The present invention relates to the use of 2-amino-benzothiazoles, having the formula wherein R 1 is hexahydrofuro[2,3-b]furanyl, tetrahydrofuranyl, oxazolyl, thiazolyl, pyridinyl, or phenyl optionally substituted with one or more substituents independently selected from C 1-6 alkyl, hydroxy, amino, halogen, aminoC 1-4 alkyl and mono- or di(C 1-4 alkyl)amino; R 2 is hydrogen or C 1-6 alkyl; L is a direct bond, —O—, C 1-6 alkanediyl-O— or —O—C 1-6 alkanediyl; R 3 is phenylC 1-4 alkyl; R 4 is C 1-6 alkyl; R 5 is hydrogen or C 1-6 alkyl; R 6 is hydrogen or C 1-6 alkyl; in the manufacture of a medicament useful for inhibiting mutant HIV protease in a mammal infected with said mutant HIV protease. It also relates to novel compounds of formula (I).

  本发明涉及使用2-氨基苯并噻唑，其具有式： 其中，R1为六氢呋喃[2,3-b]呋喃基，四氢呋喃基，噁唑基，噻唑基，吡啶基或苯基，可选地取代一个或多个取代基，独立地选择自C1-6烷基，羟基，氨基，卤素，氨基C1-4烷基和单烷基或双(C1-4烷基)氨基；R2为氢或C1-6烷基；L为直接键，-O-，C1-6烷二基-O-或-O-C1-6烷二基；R3为苯基C1-4烷基；R4为C1-6烷基；R5为氢或C1-6烷基；R6为氢或C1-6烷基；用于制造一种药物，有助于抑制携带该突变HIV蛋白酶的哺乳动物感染中的突变HIV蛋白酶。本发明还涉及式(I)的新化合物。