1,2,5,6-tetrahydro-3-pyridine carboxaldehyde O-methyloxime | 114485-41-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1,2,5,6-tetrahydro-3-pyridine carboxaldehyde O-methyloxime
• 英文别名: 1,2,5,6-tetrahydropyridin-3-carboxaldehyde-O-methyl oxime；1,2,5,6-Tetrahydropyridine-3-carboxaldehyde-O-methyloxime；N-methoxy-1-(1,2,3,6-tetrahydropyridin-5-yl)methanimine
• CAS: 114485-41-5
• 化学式: C₇H₁₂N₂O
• 分子量: 140.185
• InChiKey: YIQBHPFHKPIDSO-UHFFFAOYSA-N

物化性质

• 沸点：
  220.3±50.0 °C(Predicted)
• 密度：
  1.06±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  33.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,2,5,6-tetrahydro-3-pyridine carboxaldehyde O-methyloxime 在 三乙胺 作用下， 以 苯 为溶剂， 生成 Methyl ether of 1-(2-trimethylsilylethyloxy)carbonyl-1,2,5,6-tetrahydropyridin-3-carboxaldehyde oxime
  参考文献：
  名称：

  Carbamate derivatives of the oxime of

  摘要：

  用于治疗患有老年性痴呆症、阿尔茨海默病或记忆缺陷的化合物，其化学式为##STR1##其中R'代表氢，线性、支链或环烷基、烯基或炔基，含有最多8个碳原子，而R代表线性、支链或环烷基、烯基或炔基，含有最多18个碳原子，可能被取代，芳基含有最多14个碳原子，可能被取代，芳基烷基含有最多18个碳原子，可能被取代，以及它们与有机或无机酸形成的盐。

  公开号：

  US04921868A1

文献信息

• Derivatives of 1,2,5,6-tetrahydropyridin-3-carboxaldehyde oxime
  申请人：Roussel Uclaf

  公开号：US05204479A1

  公开（公告）日：1993-04-20

  The subject of the invention is the compounds of formula (I): ##STR1## in which: R represents a hydrogen atom, a saturated or unsaturated, linear, branched or cyclic alkyl radical containing up to 8 carbon atoms, R' represents an amine-containing moiety of an .alpha.-amino acid or a peptide, containing as an end group an amine-containing moiety of an .alpha.-amino acid as well as their addition salts with organic or mineral acids. The compounds of formula (I) have useful pharmacological properties which justify their use in therapeutics.

  本发明的主题是公式（I）的化合物：##STR1## 其中：R代表氢原子，饱和或不饱和的线性，分支或环烷基，含有最多8个碳原子，R'代表α-氨基酸或肽的含胺基团，包含一个α-氨基酸的含胺基团作为末端基团，以及它们与有机或无机酸的加成盐。公式（I）的化合物具有有用的药理学特性，证明它们在治疗中的使用是合理的。
• Derivatives of the oxime of 1,2,5,6-tetrahydropyridine 3-carboxaldehyde,
  申请人：Roussel Uclaf

  公开号：US05231107A1

  公开（公告）日：1993-07-27

  Compounds useful in the treatment of patients suffering from senile dementia, Alzheimer's disease or memory defects, of the formula ##STR1## in which R' represents hydrogen, a linear, branched or cyclic alkyl, alkenyl or alkynyl, containing up to 8 carbon atoms, and R represents a linear, branched or cyclic alkyl, alkenyl, or alkynyl, containing up to 18 carbon atoms, possibly substituted, aryl containing up to 14 carbon atoms, possibly substituted, aralkyl containing up to 18 carbon atoms, possibly substituted, as well as their addition salts with organic or mineral acids, and to compounds of formula (I) in which R represents phenyl substituted in the 4 position by Br, F, CH.sub.3, NO.sub.2 or C(CH.sub.3).sub.2 C(CH.sub.3).sub.3 and R' represents CH.sub.3.

  该复合物适用于治疗老年性痴呆、阿尔茨海默病或记忆障碍的患者，其化学式为##STR1## 其中R'代表氢，线性、支链或环烷基、烯基或炔基，含有最多8个碳原子，而R代表线性、支链或环烷基、烯基或炔基，含有最多18个碳原子，可能被取代，芳基含有最多14个碳原子，可能被取代，芳基烷基含有最多18个碳原子，可能被取代，以及它们与有机或无机酸的加成盐，以及化学式(I)中R代表苯基，取代在4位上的Br，F，CH.sub.3，NO.sub.2或C（CH.sub.3）.sub.2 C（CH.sub.3）.sub.3，而R'代表CH.sub.3的化合物。
• Carbamate derivatives of the oxime of
  申请人：Roussel Uclaf

  公开号：US04921868A1

  公开（公告）日：1990-05-01

  Compounds useful in the treatment of patients suffering from senile dementia, Alzheimer's disease, or memory defects, of the formula ##STR1## in which R' represents hydrogen, a linear, branched or cyclic alkyl, alkenyl or alkynyl, containing up to 8 carbon atoms, and R represents a linear, branched or cyclic alkyl, alkenyl, or alkynyl, containing up to 18 carbon atoms, possibly substituted, aryl containing up to 14 carbon atoms, possibly substituted, aralkyl containing up to 18 carbon atoms, possibly substituted, as well as their addition salts with organic or mineral acids.

  用于治疗患有老年性痴呆症、阿尔茨海默病或记忆缺陷的化合物，其化学式为##STR1##其中R'代表氢，线性、支链或环烷基、烯基或炔基，含有最多8个碳原子，而R代表线性、支链或环烷基、烯基或炔基，含有最多18个碳原子，可能被取代，芳基含有最多14个碳原子，可能被取代，芳基烷基含有最多18个碳原子，可能被取代，以及它们与有机或无机酸形成的盐。