methyl 2-methyl-4-(naphthalen-1-yl)-6-oxo-1,4,5,6-tetrahydropyridine-3-carboxylate | 313967-71-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: methyl 2-methyl-4-(naphthalen-1-yl)-6-oxo-1,4,5,6-tetrahydropyridine-3-carboxylate
• 英文别名: methyl 6-methyl-4-naphthalen-1-yl-2-oxo-3,4-dihydro-1H-pyridine-5-carboxylate
• CAS: 313967-71-4
• 化学式: C₁₈H₁₇NO₃
• 分子量: 295.338
• InChiKey: CBXOFBAIZCSBTI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (E)-4-hydroxy-4-methyl-1-(naphthalen-1-yl)pent-1-en-3-one 、 β-氨基巴豆酸甲酯 在 2-(2,4,6-trimethyl-phenyl)-2,5,6,7-tetrahydro-pyrrolo[2,1-c] [1,2,4]triazol-4-ylium perchlorate 、 3,3',5,5'-四叔丁基-4,4'-联苯醌 、 potassium carbonate 作用下， 以 甲苯 为溶剂， 反应 12.0h， 以88%的产率得到methyl 2-methyl-4-(naphthalen-1-yl)-6-oxo-1,4,5,6-tetrahydropyridine-3-carboxylate
  参考文献：
  名称：

  Enantioselective Synthesis of Dihydropyridinones via NHC-Catalyzed Aza-Claisen Reaction

  摘要：

  N-Heterocyclic carbene catalyzed aza-Claisen annulations of enals or their alpha'-hydrozyenone surrogates with vinylogous amides afford dihydropyridinones. The reaction proceeds with a broad range of substrates, and no nitrogen protecting group is required.

  DOI：

  10.1021/ol202272t

文献信息

• Compounds, Compositions and Methods of Inhibiting Alpha-Synuclein Toxicity
  申请人：Lindquist Susan L.

  公开号：US20080261953A1

  公开（公告）日：2008-10-23

  Compounds and compositions are provided for treatment or amelioration of one or more symptoms of α-synuclein toxicity, α-synuclein mediated diseases or diseases in which α-synuclein fibrils are a symptom or cause of the disease. In one embodiment, the compounds for use in the compositions and methods are heteroaryl acylguanidines, heteroarylhydrazones, dihy-dropyridones, heteroaryl and aryl styryl ketones, and heteroarylpyrazoles.

  提供了化合物和组合物，用于治疗或缓解α-突触核蛋白毒性、α-突触核蛋白介导的疾病或α-突触核蛋白纤维是疾病症状或病因的疾病中的一个或多个症状。在一种实施例中，用于组合物和方法的化合物是杂环基酰基胍、杂环基腙、二氢吡啶酮、杂环基和芳基苯乙酮以及杂环基吡唑。
• COMPOUNDS AND METHODS FOR MODULATING PROTEIN TRAFFICKING
  申请人：Bulawa Christine

  公开号：US20100004277A1

  公开（公告）日：2010-01-07

  Disclosed are compositions and methods for modulating protein trafficking and treating or preventing disorders characterized by impaired protein trafficking. Also disclosed are methods for identification of compounds that rescue protein trafficking defects and methods of enhancing protein production.
• US8440705B2
  申请人：——

  公开号：US8440705B2

  公开（公告）日：2013-05-14
• Enantioselective Synthesis of Dihydropyridinones via NHC-Catalyzed Aza-Claisen Reaction
  作者：Benedikt Wanner、Jessada Mahatthananchai、Jeffrey W. Bode

  DOI：10.1021/ol202272t

  日期：2011.10.7

  N-Heterocyclic carbene catalyzed aza-Claisen annulations of enals or their alpha'-hydrozyenone surrogates with vinylogous amides afford dihydropyridinones. The reaction proceeds with a broad range of substrates, and no nitrogen protecting group is required.