trans-3-Heptene-1,7-diamine | 62577-93-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: trans-3-Heptene-1,7-diamine
• 英文别名: (E)-hept-3-ene-1,7-diamine
• CAS: 62577-93-9
• 化学式: C₇H₁₆N₂
• 分子量: 128.217
• InChiKey: GZVIKXWCJWJPFM-OWOJBTEDSA-N

物化性质

• 沸点：
  225.5±28.0 °C(Predicted)
• 密度：
  0.883±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  trans-3-Heptene-1,7-diamine 、 4-(二氟甲氧基)苯甲酸 生成 C₂₃H₂₄F₄N₂O₄
  参考文献：
  名称：

  N,N'-Heptamethylenebis(4-methoxybenzamide)

  摘要：

  4-(Q-O)-4'-R.sub.1 -N,N'-烷基亚苯二酰胺，N,N'-烷基亚苯二酰胺或N,N'-烷基亚苯二酰胺[4-(较低烷氧基)苯二酰胺]，具有内分泌学性质，其中Q为较低烷基，较低烷氧基烷基，较低烯基，卤代较低烷基，卤代较低烯基，较低环烷基，苯基和BN-(较低烷基)，其中BN为二(较低烷基)氨基或具有五至七个环原子的饱和N-杂环烷基基团，烷基在其两个连接链之间至少有五个碳原子，R.sub.1为Q-O-，氢，较低烷氧基，较低烷基，卤素，苄氧基，羟基，二(较低烷基)氨基，硝基，氨基或三卤甲基，最好通过将适当的二胺或N-(氨基烷基)-苯二酰胺与相应的苯甲酰卤反应制备两个或一个摩尔当量。

  公开号：

  US04009208A1
• 作为产物：
  描述：

  2-(4-戊炔氧基)四氢-2H-吡喃 在 N,N-二甲基丙烯基脲 、 lithium aluminium tetrahydride 、 正丁基锂 、 sodium azide 、 stones 、 4-甲基苯磺酸吡啶 、 三乙胺 、 三苯基膦 作用下， 以 四氢呋喃 、 乙醇 、 二氯甲烷 、 水 、 二甲基亚砜 为溶剂， 反应 25.25h， 生成 trans-3-Heptene-1,7-diamine
  参考文献：
  名称：

  Branched-chain and unsaturated 1,7-Diaminoheptane derivatives as deoxyhypusine synthase inhibitors

  摘要：

  Deoxyhypusine synthase catalyzes the first step in the posttranslational biosynthesis of the unusual amino acid hypusine [N-epsilon-(4-amino-2-hydroxybutyl)lysine] in eukaryotic translation initiation factor 5A (eIF-SA). eIF-SA and its single hypusine residue are essential for cell proliferation. Two series of 1,7-diaminoheptane derivatives were prepared and tested as inhibitors of human deoxyhypusine synthase. These include branched-chain saturated derivatives and both branched- and straight-chain unsaturated derivatives providing size and positional variation in branching and different torsional constraints. Of the branched-chain compounds, 7-amino-1-guanidinooctane (39) proved to be the most potent inhibitor in vitro (IC50, 34 nM), while 1,7-diamino-trans-hept-3-ene (20a) displayed the greatest inhibition (IC50, 0.7 mu M) among the unsaturated compounds. Compound 39 also provided effective inhibition of hypusine production in Chinese hamster ovary cells in culture. Considerations of the in vitro inhibition data reported here, along with earlier findings, allowed some speculation concerning the conformation of the substrate spermidine during its productive interaction at the active site of deoxyhypusine synthase. Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0968-0896(97)10030-x

文献信息

• Dendrimers as molecular translocators
  申请人：Goodman Murray

  公开号：US20060216265A1

  公开（公告）日：2006-09-28

  Transport molecules include a dendrimer and a biologically active molecule. The dendrimer of such transport molecules includes at least one guanidine group, at least one protonated guanidine group, at least one protected guanidine group, at least one amidine group, at least one protonated amidine group, at least one protected amidine group, at least one ureido group, at least one protonated ureido group, at least one protected ureido group, at least one thioureido group, at least one protonated thioureido group, or at least one protected thioureido group. The biologically active molecule is bonded to the dendrimer. A method of increasing the bioavailability of a drug includes bonding the drug to a dendrimer of the invention.

  转运分子包括一种树枝状聚合物和一种生物活性分子。这些转运分子的树枝状聚合物包括至少一个胍基团、至少一个质子化的胍基团、至少一个保护的胍基团、至少一个酰胺基团、至少一个质子化的酰胺基团、至少一个保护的酰胺基团、至少一个脲基团、至少一个质子化的脲基团、至少一个保护的脲基团、至少一个硫脲基团、至少一个质子化的硫脲基团，或至少一个保护的硫脲基团。生物活性分子与树枝状聚合物结合。一种增加药物生物利用度的方法包括将药物与本发明的树枝状聚合物结合。
• MULTIPLE CHARGED IONIC COMPOUNDS DERIVED FROM POLYAMINES AND COMPOSITIONS THEREOF AND METHODS OF PREPARATION THEREOF
  申请人：Ecolab USA Inc.

  公开号：US20200071261A1

  公开（公告）日：2020-03-05

  Disclosed herein are the multiple charged cationic or anionic compounds, methods of making thereof, and articles or compositions comprising thereof. The disclosed multiple charged cationic or anionic compounds are derived from polyamines through two reactions: an aza-Michael addition with an activated olefin having an ionic group and a ring-opening reaction with an epoxide.

  本文披露了多价阳离子或阴离子化合物，其制备方法和包含它们的文章或组合物。披露的多价阳离子或阴离子化合物是通过两个反应从多胺中衍生而来的：与带有离子基团的活性烯烃进行氮杂Michael加成反应和与环氧化物进行开环反应。
• Dendrimers as Molecular Translocators
  申请人：Goodman Murray

  公开号：US20080221020A1

  公开（公告）日：2008-09-11

  Transport molecules include a dendrimer and a biologically active molecule. The dendrimer of such transport molecules includes at least one guanidine group, at least one protonated guanidine group, at least one protected guanidine group, at least one amidine group, at least one protonated amidine group, at least one protected amidine group, at least one ureido group, at least one protonated ureido group, at least one protected ureido group, at least one thioureido group, at least one protonated thioureido group, or at least one protected thioureido group. The biologically active molecule is bonded to the dendrimer. A method of increasing the bioavailability of a drug includes bonding the drug to a dendrimer of the invention.

  运输分子包括一个树状分子和一个生物活性分子。这种运输分子的树状分子包括至少一个鸟氨酸基团，至少一个质子化的鸟氨酸基团，至少一个保护的鸟氨酸基团，至少一个酰胺基团，至少一个质子化的酰胺基团，至少一个保护的酰胺基团，至少一个尿素基团，至少一个质子化的尿素基团，至少一个保护的尿素基团，至少一个硫脲基团，至少一个质子化的硫脲基团，或者至少一个保护的硫脲基团。生物活性分子与树状分子结合。一种增加药物生物利用度的方法包括将药物与本发明的树状分子结合。
• Multiple charged ionic compounds derived from polyamines and compositions thereof and methods of preparation thereof
  申请人：Ecolab USA Inc.

  公开号：US11236040B2

  公开（公告）日：2022-02-01

  Disclosed herein are the multiple charged cationic or anionic compounds, methods of making thereof, and articles or compositions comprising thereof. The disclosed multiple charged cationic or anionic compounds are derived from polyamines through two reactions: an aza-Michael addition with an activated olefin having an ionic group and a ring-opening reaction with an epoxide.

  本文公开了多电荷阳离子或阴离子化合物、其制造方法以及由其组成的物品或组合物。所公开的多电荷阳离子或阴离子化合物由多胺通过两个反应衍生而来：与具有离子基团的活化烯烃的氮杂迈克尔加成反应，以及与环氧化物的开环反应。
• DENDRIMERS AS MOLECULAR TRANSLOCATORS
  申请人：The Regents of the University of California

  公开号：EP1545462A2

  公开（公告）日：2005-06-29