trans-β-Phenoxyacrylsaeure | 109317-71-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: trans-β-Phenoxyacrylsaeure
• 英文别名: (E)-3-phenoxyprop-2-enoic acid
• CAS: 109317-71-7
• 化学式: C₉H₈O₃
• 分子量: 164.161
• InChiKey: RYQWTNSICNJGCJ-VOTSOKGWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  trans-(2-Phenoxyvinyl) trifluoromethyl ketone 在 氢氧化钾 、 水 作用下， 以 苯 为溶剂， 反应 1.0h， 以81%的产率得到trans-β-Phenoxyacrylsaeure
  参考文献：
  名称：

  A Convenient Synthetic Method for β-Alkoxy- and β-Phenoxyacrylic Acids and 3,4-Dihydro-2H-pyran-5- and 2,3-Dihydrofuran-4-carboxylic Acids

  摘要：

  反δ-²-三卤乙酰乙烯基醚 1 很容易在苯中被湿氢氧化钾水解，从而以极好的收率生成相应的酸 2。这种合成方法也可用于环乙烯基醚 3 和 5，从而以较高的产率制得 4 和 6。

  DOI：

  10.1055/s-1986-31854

文献信息

• [EN] CARBAMOYL COMPOUNDS AS DGAT1 INHIBITORS 190<br/>[FR] COMPOSÉS CARBAMOYLES COMME INHIBITEURS DE DGAT1 190
  申请人：ASTRAZENECA AB

  公开号：WO2009081195A1

  公开（公告）日：2009-07-02

  DGAT-1 inhibitor compounds of formula (I), pharmaceutically-acceptable salts and pro- drugs thereof are described, together with pharmaceutical compositions, processes for making them and their use in treating, for example, obesity wherein, for example, Ring A is optionally substituted 2,6-pyrazindiyl; X is =O; Ring B is optionally substituted 1,4-phenylene; Y1 is a direct bond or -O-; Y2 is -(CH 2) r- wherein r is 2 or 3; n is 0 or n is 1 when Y1 is a direct bond between Ring B and Ring C and when Ring B is 1,4-phenylene and Ring C is (4-6C)cycloalkane; Ring C is optionally substituted (4-6C)cycloalkane, (7-10C)bicycloalkane, (8-12C)tricycloalkane, phenylene or pryidindiyl; L is a direct bond or -O-; p is 0, 1 or 2 and when p is 1 or 2 RA1 and RA2 are each independently hydrogen or (1-4C)alkyl; Z is carboxy or a mimic or bioisostere thereof.

  DGAT-1抑制剂化合物公式(I)，药用可接受的盐和前药，以及药物组合物、制造它们的过程以及它们在治疗例如肥胖症中的用途，其中，例如，环A是可选取代的2,6-吡嗪二基；X是=O；环B是可选取代的1,4-苯基；Y1是直接键或-O-；Y2是-(CH2)r-，其中r是2或3；n是0或当Y1是环B和环C之间的直接键并且当环B是1,4-苯基和环C是(4-6C)环烷时，n是1；环C是可选取代的(4-6C)环烷、(7-10C)双环烷、(8-12C)三环烷、苯基或吡啶二基；L是直接键或-O-；p是0、1或2，并且当p是1或2时，RA1和RA2各自独立地为氢或(1-4C)烷基；Z是羧酸或其模拟物或生物等排体。
• CURABLE COMPOSITION FOR IMPRINTS AND PRODUCING METHOD OF POLYMERIZABLE MONOMER FOR IMPRINTS
  申请人：Kodama Kunihiko

  公开号：US20120076950A1

  公开（公告）日：2012-03-29

  Provided is a curable composition for imprints excellent in pattern transferability. Disclosed is a curable composition for imprints comprising a polymerizable monomer (A) and a polymerization initiator (B), which is substantially free from a polymer which contains at least one species of the polymerizable monomer (A) as a repeating unit.

  提供了一种适用于图案易传递的可治愈组合物。公开了一种适用于图案印记的可治愈组合物，包括可聚合单体（A）和聚合引发剂（B），其基本上不含至少一种将可聚合单体（A）作为重复单元的聚合物。
• Transmission of Substituent Effects through Oxygen and Sulfur Atoms. III. The Ionization Equilibrium Constants of Ring-substituted<i>cis</i>-β-Phenoxyacrylic Acids
  作者：Okitsugu Kajimoto、Masaru Kobayashi、Takayuki Fueno

  DOI：10.1246/bcsj.46.1425

  日期：1973.5

  cis-β-Phenoxyacrylic acid and several of its ring-substituted derivatives were prepared, and their ionization constants were determined in 50% ethanol–water at 25 °C. The Hammett ρ value for the ionization of these acids, 0.439, is smaller than that reported for cis-β-phenylthioacrylic acids, 0.531. The greater efficiency of the sulfur atom in transmitting the substituent effects is explainable in terms

  制备了顺式-β-苯氧基丙烯酸及其几种环取代衍生物，并在 25°C 下在 50% 乙醇-水中测定了它们的电离常数。这些酸的电离的哈米特 ρ 值 0.439 小于报道的顺式-β-苯基硫代丙烯酸的值 0.531。硫原子在传递取代基效应方面的更高效率可以用硫原子在形成的硫代丙烯酸酯阴离子中的“通过共轭”来解释。
• Active agent delivery systems and methods for protecting and administering active agents
  申请人：New River Pharmaceuticals Inc.

  公开号：US20040063628A1

  公开（公告）日：2004-04-01

  The present invention relates to active agent delivery systems and more specifically to compositions that comprise amino acids, as single amino acids or peptides, covalently attached to active agents and methods for administering conjugated active agent compositions.

  本发明涉及活性物质输送系统，更具体地涉及包含氨基酸，作为单个氨基酸或肽的组成部分，与活性物质共价连接的组合物和用于给予共轭活性物质组合物的方法。
• CURABLE COMPOSITION FOR IMPRINT, PATTERNING METHOD AND PATTERN
  申请人：Kodama Kunihiko

  公开号：US20110059302A1

  公开（公告）日：2011-03-10

  A curable composition for imprints, which is excellent in patternability and in line edge roughness, is provided. The curable composition for imprints comprises at least one kind of polymerizable monomer (A) and at least one kind of photopolymerization initiator (B). The polymerizable monomer (A) comprises at least two fluorine-containing groups selected from a fluoroalkyl group and a fluoroalkylether group and each of two of the fluorine-containing groups is connected with each other through a linking group having at least two carbon atoms.

  提供了一种可治愈的印迹组合物，其在图案化和线边粗糙度方面表现出色。该可固化的印迹组合物包括至少一种聚合单体（A）和至少一种光聚合引发剂（B）。聚合单体（A）包括至少两种含氟基团，所选基团为氟烷基或氟烷基醚基，其中每两个含氟基团通过具有至少两个碳原子的连接基团相互连接。