2,6-Dimethyl-4-(4-thiomorpholinyl)pyridine-3-carboxamide 1-oxide | 106101-20-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2,6-Dimethyl-4-(4-thiomorpholinyl)pyridine-3-carboxamide 1-oxide
• 英文别名: 2,6-dimethyl-1-oxido-4-thiomorpholin-4-ylpyridin-1-ium-3-carboxamide
• CAS: 106101-20-6
• 化学式: C₁₂H₁₇N₃O₂S
• 分子量: 267.352
• InChiKey: BFOFEOBHJHJJRG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  97.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,6-Dimethyl-1-oxido-4-thiomorpholin-4-ylpyridin-1-ium-3-carbonitrile 生成 2,6-Dimethyl-4-(4-thiomorpholinyl)pyridine-3-carboxamide 1-oxide
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Multiply substituted pyridine 1-oxide compounds which are useful in
  申请人：Hoechst Aktiengesellschaft

  公开号：US04859663A1

  公开（公告）日：1989-08-22

  Multiply substituted pyridine 1-oxides of the formula I ##STR1## in which R.sup.1 and R.sup.2 are, in each case, identical or different and represent alkyl having 1 to 6 carbon atoms, R.sup.3 denotes hydrogen, and R.sup.4 denotes mercaptoalkyl having up to 4 carbon atoms, or R.sup.3 and R.sup.4 form, together with the nitrogen atom in the 4-position, a five- to seven-membered saturated heterocyclic ring which has up to 2 heteroatoms, the second heteroatom being oxygen, sulfur which can carry up to two oxygen atoms, or nitrogen in the form of the NR.sup.6 group, in which R.sup.6 is hydrogen, alkyl having up to 2 carbon atoms, phenylalkyl having up to 2 carbon atoms in the alkyl moiety or phenyl, and the phenyl rings in the two latter radicals can carry up to two identical or different substituents from the group comprising halogen and methoxy, and which ring is unsubstituted or carries up to two identical or different substituents from the group comprising hydroxy and alkyl having up to 2 carbon atoms, and X denotes the cyano or nitro group the or the group --CO--R.sup.5, in which R.sup.5 represents the amino, hydroxyl or an alkoxy group having up to 4 carbon atoms, and the physiologically tolerated salts of these compounds, and medicaments containing or composed of these compounds. The invention further relates to a process for the preparation of the multiply substituted pyridine 1-oxides of the formula I, and to their use for the preparation of medicaments whcih are intended for the prevention and treatment of brain disorders caused by vascular and degenerative factors.

  公式I中，多取代吡啶1-氧化物的化学式为##STR1## 其中，R.sup.1和R.sup.2在每种情况下都相同或不同，并代表具有1至6个碳原子的烷基，R.sup.3代表氢，R.sup.4代表具有最多4个碳原子的巯基烷基，或R.sup.3和R.sup.4与4-位置的氮原子一起形成一个具有最多2个杂原子的五至七元饱和杂环，第二个杂原子是氧，硫可以携带最多两个氧原子，或以NR.sup.6基团的形式存在的氮，其中R.sup.6是氢，具有最多2个碳原子的烷基，具有最多2个碳原子的苯基烷基或苯基，后两个基团中的苯环可以携带最多两个相同或不同的卤素和甲氧基取代基，该环未取代或携带最多两个相同或不同的羟基和具有最多2个碳原子的烷基取代基，X代表氰基或硝基基团或--CO--R.sup.5基团，其中R.sup.5代表具有最多4个碳原子的氨基，羟基或烷氧基基团，以及这些化合物的生理耐受盐和含有或由这些化合物组成的药物。本发明还涉及制备公式I中的多取代吡啶1-氧化物的方法，以及它们用于制备用于预防和治疗由血管和退行性因素引起的脑部疾病的药物。
• ——
  作者：GREVE W.、 ELBEN U.、 RUDOLPHI K.、 SCHINDLER U.

  DOI：——

  日期：——
• US4859663A
  申请人：——

  公开号：US4859663A

  公开（公告）日：1989-08-22